DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment amd and Gad1

DIOPT Version :9

Sequence 1:	NP_476592.1	Gene:	amd / 35188	FlyBaseID:	FBgn0000075	Length:	510	Species:	Drosophila melanogaster
Sequence 2:	NP_032103.2	Gene:	Gad1 / 14415	MGIID:	95632	Length:	593	Species:	Mus musculus

Alignment Length:	523	Identity:	132/523 - (25%)
Similarity:	218/523 - (41%)	Gaps:	99/523 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 EFGKAAIDYIADYLENI--RDDDVLPNVEPGYLLDLLP---TEMPEEPEAWKDVLGDISRVIKPG 67
            :|....:|.:.:|:...  |...||....|..||:.:.   .|:.:.||:.:.:|.|....:|
Mouse   114 QFLLEVVDILLNYVRKTFDRSTKVLDFHHPHQLLEGMEGFNLELSDHPESLEQILVDCRDTLK-- 176

  Fly    68 LTHWQSPHMHAYYPTSTSYPSIVGEMLASGFGVIGFS--WICSPACTEL---EV----VVMDWLA 123
                        |...|.:|....: |::|..:||.:  |:.|.|.|.:   |:    |:|:.:.
Mouse   177 ------------YGVRTGHPRFFNQ-LSTGLDIIGLAGEWLTSTANTNMFTYEIAPVFVLMEQIT 228

  Fly   124 KFLKLPAHFQHASDGPGGGVIQGSASEAVLVAVLAAREQAVANYRESHPELSESEVRG-----RL 183
              ||........|:..|.|:.....:.:.:.:::|||          :....|.:.:|     :|
Mouse   229 --LKKMREIVGWSNKDGDGIFSPGGAISNMYSIMAAR----------YKYFPEVKTKGMAAVPKL 281

  Fly   184 VAYSSDQSNSCIEKAGVLAAMPIRLLPAGEDFVL------RGDTLRGAIEEDV----AAGRIPVI 238
            |.::|:.|:..|:|||.       .|..|.|.|:      ||..:...:|..:    ..|.:|:.
Mouse   282 VLFTSEHSHYSIKKAGA-------ALGFGTDNVILIKCNERGKIIPADLEAKILDAKQKGYVPLY 339

  Fly   239 CVATLGTTGTCAYDDIESLSAVCEEFKVWLHVDAAYAGGAFALEECSDLRKGLDRVDSLNFNLHK 303
            ..||.|||...|:|.|:.::.:||::.:|||||||:.||.....:......|::|.:|:.:|.||
Mouse   340 VNATAGTTVYGAFDPIQEIADICEKYNLWLHVDAAWGGGLLMSRKHRHKLSGIERANSVTWNPHK 404

  Fly   304 FMLVNFDCSAMWLRD------ANKVVDS--FNVDRIYLKHKHEGQSQIPDFRHWQIPLGRRFRAL 360
            .|.|...|||:.:::      .|::...  |..|:.|......|...|...||..|        .
Mouse   405 MMGVLLQCSAILVKEKGILQGCNQMCAGYLFQPDKQYDVSYDTGDKAIQCGRHVDI--------F 461

  Fly   361 KVWITFRTLGAEGLRNHVRKHIELAKQFEQLVLKDSRFELV---APRALGLVCF-------RPKG 415
            |.|:.::..|..|..|.:.|.:|||......:.....||:|   .|.... |||       |...
Mouse   462 KFWLMWKAKGTVGFENQINKCLELADYLYAKIKNREEFEMVFDGEPEHTN-VCFWYIPQSLRGVP 525

  Fly   416 DNEITTQLLQRLMDRKKIYMVKA--EHAGRQ-------FLRFVVCGMDTKASDIDFAWQEIESQL 471
            |:....:.|.|:..:.|..|:::  ...|.|       |.|.|:.......|||||..:|||...
Mouse   526 DSPERREKLHRVAPKIKALMMESGTTMVGYQPQGDKANFFRMVISNPAATQSDIDFLIEEIERLG 590

  Fly   472 TDL 474
            .||
Mouse   591 QDL 593

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
amd	NP_476592.1	Pyridoxal_deC	35..414	CDD:278699	106/423 (25%)
Gad1	NP_032103.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..22
		Pyridoxal_deC	143..517	CDD:365998	105/416 (25%)
		Substrate binding. /evidence=ECO:0000250	189..191		0/2 (0%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0076
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810