DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment amd and gad3

DIOPT Version :9

Sequence 1:	NP_476592.1	Gene:	amd / 35188	FlyBaseID:	FBgn0000075	Length:	510	Species:	Drosophila melanogaster
Sequence 2:	NP_001083039.2	Gene:	gad3 / 100038790	ZFINID:	ZDB-GENE-070424-80	Length:	546	Species:	Danio rerio

Alignment Length:	527	Identity:	130/527 - (24%)
Similarity:	210/527 - (39%)	Gaps:	113/527 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 EFGKAAIDYIADYLENI----------RDDDVLPNVEPGYL---LDLLPTEMPEEPEAWKDVLGD 59
            |.|:.|..:....|.||          |...||....|..|   |:....|:|::|:..:.:|.|
Zfish    59 EDGEEATKHFLQELVNILLAYISKSLKRSTKVLDFHYPHQLNEGLEGFSLELPDQPDNLEQLLVD 123

  Fly    60 ISRVIKPGLTHWQSPHMHAYYPTSTSYP--SIVGEMLASGFGVIGFSWICSPACTELEVVVMDWL 122
            ....:|.|:   ::.|...:...||...  .:.||.|.|......|::..||....:|.||:..:
Zfish   124 CRDTLKYGV---KTGHPRFFNQLSTGLDIVGLAGEWLTSTANTNMFTYEISPVFILMEEVVLRKM 185

  Fly   123 AKFLKLPAHFQHASDG---PGGGVIQGSASEAVLVAVLAAREQ---AVANYRESH-----PELSE 176
            ...:..|   :...||   |||       |.:.|.:||.||..   ||    ::|     |
Zfish   186 HTIIGWP---EEDGDGIFCPGG-------SMSNLYSVLLARFHLFPAV----KTHGMCAIP---- 232

  Fly   177 SEVRGRLVAYSSDQSNSCIEKAGVLAAMPIRLLPAGEDFVL------RG----DTLRGAIEEDVA 231
                 ||..::|..|:..|:|:..       :|..|.:.|:      ||    ..|..:|||..:
Zfish   233 -----RLAMFTSAHSHYSIKKSAA-------VLGIGTENVIVVRCDERGKMISSELNSSIEEAKS 285

  Fly   232 AGRIPVICVATLGTTGTCAYDDIESLSAVCEEFKVWLHVDAAYAGGAFALEECSDLRKGLDRVDS 296
            .|.:|....||.|||...|:|.:..::.:||...:|:|||||:.||.....:......|::|..|
Zfish   286 KGLVPFYVNATAGTTVYGAFDPLHKIADICEHHGLWMHVDAAWGGGLLLSNKHRVKLHGIERAHS 350

  Fly   297 LNFNLHKFMLVNFDCSAM------WLRDANKVVDSFNVDRIYLKHKHEGQSQIPDFRHWQIPLGR 355
            :.:|.||.|.|...||.:      .|:..|::...:    ::...||...|.  |.....|..||
Zfish   351 VTWNPHKMMGVPLQCSTILVKRKGLLQQCNQLCAEY----LFQPDKHYEVSY--DTGDKSIQCGR 409

  Fly   356 RFRALKVWITFRTLGAEGLRNHVRKHIELAKQFEQLVLKDSRFELVAPRALGLVCFRPKGDNEIT 420
            .....|:|:.::..|:||..:.|...:|.|:.....:.:.:.|:||...       :|:..|...
Zfish   410 HVDIFKLWLMWKAKGSEGFESQVNHCLENAEYLYYKLKRRTDFQLVFKG-------KPEHSNVCF 467

  Fly   421 TQLLQRLMD-------RKKIYMVKAE-----------HAGRQ-------FLRFVVCGMDTKASDI 460
            ..|.:|:.:       .|:::||..:           ..|.|       |.|.|.....|:..|:
Zfish   468 WYLPKRVQNIPLGPEREKELHMVAPKIKTKMMEEGFTMIGYQPLEDKVNFFRCVFSNPATQREDV 532

  Fly   461 DFAWQEI 467
            ||...||
Zfish   533 DFLLDEI 539

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
amd	NP_476592.1	Pyridoxal_deC	35..414	CDD:278699	103/410 (25%)
gad3	NP_001083039.2	Pyridoxal_deC	96..469	CDD:278699	105/418 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0076
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.810