Protein Alignment Lim3 and LHX4

DIOPT Version :10

• Sequence 1: NP_001260559.1
• Gene: Lim3 / 35184
• FlyBaseID: FBgn0002023
• Length: 555
• Species: Drosophila melanogaster
• Sequence 2: NP_203129.1
• Gene: LHX4 / 89884
• HGNCID: 21734
• Length: 390
• Species: Homo sapiens
• Alignment Length: 386
• Identity: 191/386 - (49%)
• Similarity: 233/386 - (60%)
• Gaps: 61/386 - (15%)

  Fly   119 IPKCGGCHELILDRFILKVLERTWHAKCLQCSECHGQLNDKCFARNGQLFCKEDFFKRYGTKCSA 183
            ||:|.||::.|||:||||||:|.||:.||:|::|..||.|:||:|.|.::||||||||:||||:|
Human    27 IPQCAGCNQHILDKFILKVLDRHWHSSCLKCADCQMQLADRCFSRAGSVYCKEDFFKRFGTKCTA 91

  Fly   184 CDMGIPPTQVVRRAQDNVYHLQCFLCAMCSRTLNTGDEFYLMEDRKLICKRDYEEAKAKGLYLDG 248
            |..|||||||||:|||.||||.||.|.:|:|.|.||||||||||.:|:||.|||.||...
Human    92 CQQGIPPTQVVRKAQDFVYHLHCFACIICNRQLATGDEFYLMEDGRLVCKEDYETAKQND----- 151

  Fly   249 SLDGDQPNKRPRTTITAKQLETLKTAYNNSPKPARHVREQLSQDTGLDMRVVQVWFQNRRAKEKR 313
              |.:...||||||||||||||||.||.||||||||||||||.:|||||||||||||||||||||
Human   152 --DSEAGAKRPRTTITAKQLETLKNAYKNSPKPARHVREQLSSETGLDMRVVQVWFQNRRAKEKR 214

  Fly   314 LKKDAGRTRWSQYFRSMK-GNCSPRTDKFLDKDELKVDYDSFSHHD------------------- 358
            |||||||.||.|:::|:| ...|.:.:|....::..|.....|..:
Human   215 LKKDAGRHRWGQFYKSVKRSRGSSKQEKESSAEDCGVSDSELSFREDQILSELGHTNRIYGNVGD 279

  Fly   359 -----LSNDSYSTVNLG-----LDEGASPHSIRGSYMHGSSSPSQYPPSSRSPPPVGQGHTFGSY 413
                 |.|.|:|....|     |.:| ||:.|..|....||.||..|                 .
Human   280 VTGGQLMNGSFSMDGTGQSYQDLRDG-SPYGIPQSPSSISSLPSHAP-----------------L 326

  Fly   414 PDNIVYTNIDQAVGSSLHASKAHH---RLHSSNNVSDLSNDSSPDQGYPDFPPSPDSWLGD 471
            .:.:.|| :|..:|...||.:...   |..:....||:|..||  .||||||.||.|||.:
Human   327 LNGLDYT-VDSNLGIIAHAGQGVSQTLRAMAGGPTSDISTGSS--VGYPDFPTSPGSWLDE 384

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Lim3	NP_001260559.1	LIM1_Lhx3_Lhx4	122..173	CDD:188754	29/50 (58%)
		LIM2_Lhx3_Lhx4	181..236	CDD:188762	38/54 (70%)
		Homeodomain	257..313	CDD:459649	51/55 (93%)
LHX4	NP_203129.1	LIM1_Lhx4	30..81	CDD:188852	29/50 (58%)
		LIM2_Lhx3_Lhx4	89..144	CDD:188762	38/54 (70%)
		Homeodomain	158..214	CDD:459649	51/55 (93%)
		Interaction with DNA. /evidence=ECO:0000305|PubMed:28473536	161..181		17/19 (89%)
		Interaction with 5-mCpG DNA. /evidence=ECO:0000305|PubMed:28473536	199..211		11/11 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	230..253		5/22 (23%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	356..390		16/31 (52%)