DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Lim3 and LHX4

DIOPT Version :9

Sequence 1:	NP_001260559.1	Gene:	Lim3 / 35184	FlyBaseID:	FBgn0002023	Length:	555	Species:	Drosophila melanogaster
Sequence 2:	NP_203129.1	Gene:	LHX4 / 89884	HGNCID:	21734	Length:	390	Species:	Homo sapiens

Alignment Length:	386	Identity:	191/386 - (49%)
Similarity:	233/386 - (60%)	Gaps:	61/386 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   119 IPKCGGCHELILDRFILKVLERTWHAKCLQCSECHGQLNDKCFARNGQLFCKEDFFKRYGTKCSA 183
            ||:|.||::.|||:||||||:|.||:.||:|::|..||.|:||:|.|.::||||||||:||||:|
Human    27 IPQCAGCNQHILDKFILKVLDRHWHSSCLKCADCQMQLADRCFSRAGSVYCKEDFFKRFGTKCTA 91

  Fly   184 CDMGIPPTQVVRRAQDNVYHLQCFLCAMCSRTLNTGDEFYLMEDRKLICKRDYEEAKAKGLYLDG 248
            |..|||||||||:|||.||||.||.|.:|:|.|.||||||||||.:|:||.|||.||...
Human    92 CQQGIPPTQVVRKAQDFVYHLHCFACIICNRQLATGDEFYLMEDGRLVCKEDYETAKQND----- 151

  Fly   249 SLDGDQPNKRPRTTITAKQLETLKTAYNNSPKPARHVREQLSQDTGLDMRVVQVWFQNRRAKEKR 313
              |.:...||||||||||||||||.||.||||||||||||||.:|||||||||||||||||||||
Human   152 --DSEAGAKRPRTTITAKQLETLKNAYKNSPKPARHVREQLSSETGLDMRVVQVWFQNRRAKEKR 214

  Fly   314 LKKDAGRTRWSQYFRSMK-GNCSPRTDKFLDKDELKVDYDSFSHHD------------------- 358
            |||||||.||.|:::|:| ...|.:.:|....::..|.....|..:
Human   215 LKKDAGRHRWGQFYKSVKRSRGSSKQEKESSAEDCGVSDSELSFREDQILSELGHTNRIYGNVGD 279

  Fly   359 -----LSNDSYSTVNLG-----LDEGASPHSIRGSYMHGSSSPSQYPPSSRSPPPVGQGHTFGSY 413
                 |.|.|:|....|     |.:| ||:.|..|....||.||..|                 .
Human   280 VTGGQLMNGSFSMDGTGQSYQDLRDG-SPYGIPQSPSSISSLPSHAP-----------------L 326

  Fly   414 PDNIVYTNIDQAVGSSLHASKAHH---RLHSSNNVSDLSNDSSPDQGYPDFPPSPDSWLGD 471
            .:.:.|| :|..:|...||.:...   |..:....||:|..||  .||||||.||.|||.:
Human   327 LNGLDYT-VDSNLGIIAHAGQGVSQTLRAMAGGPTSDISTGSS--VGYPDFPTSPGSWLDE 384

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lim3	NP_001260559.1	LIM1_Lhx3_Lhx4	122..173	CDD:188754	29/50 (58%)
		LIM2_Lhx3_Lhx4	181..236	CDD:188762	38/54 (70%)
		Homeobox	259..312	CDD:278475	48/52 (92%)
LHX4	NP_203129.1	LIM1_Lhx4	30..81	CDD:188852	29/50 (58%)
		LIM2_Lhx3_Lhx4	89..144	CDD:188762	38/54 (70%)
		Homeobox	160..213	CDD:306543	48/52 (92%)
		Interaction with DNA. /evidence=ECO:0000305\|PubMed:28473536	161..181		17/19 (89%)
		Interaction with 5-mCpG DNA. /evidence=ECO:0000305\|PubMed:28473536	199..211		11/11 (100%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	230..253		5/22 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	356..390		16/31 (52%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	99	1.000	Domainoid score	I7100
eggNOG	1	0.900	-	-		E1_KOG4577
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	347	1.000	Inparanoid score	I2304
Isobase	1	0.950	-	0	Normalized mean entropy	S2759
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1174754at2759
OrthoFinder	1	1.000	-	-		FOG0002911
OrthoInspector	1	1.000	-	-		otm42212
orthoMCL	1	0.900	-	-		OOG6_106440
Panther	1	1.100	-	-	O	PTHR24208
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2568
SonicParanoid	1	1.000	-	-		X1144
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	14	13.810