DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Lim3 and Lhx1

DIOPT Version :9

Sequence 1:	NP_001260559.1	Gene:	Lim3 / 35184	FlyBaseID:	FBgn0002023	Length:	555	Species:	Drosophila melanogaster
Sequence 2:	NP_665887.3	Gene:	Lhx1 / 257634	RGDID:	71074	Length:	406	Species:	Rattus norvegicus

Alignment Length:	435	Identity:	155/435 - (35%)
Similarity:	208/435 - (47%)	Gaps:	106/435 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   122 CGGCHELILDRFILKVLERTWHAKCLQCSECHGQLNDKCFARNGQLFCKEDFFKRYGTKCSACDM 186
            |.||...|||||:|.||:|.||.||:||.||...|.:|||:|.|:|:||.|||:.:||||:.|..
  Rat     4 CAGCKRPILDRFLLNVLDRAWHVKCVQCCECKCNLTEKCFSREGKLYCKNDFFRCFGTKCAGCAQ 68

  Fly   187 GIPPTQVVRRAQDNVYHLQCFLCAMCSRTLNTGDEFYLMEDRKLICKRDY----EEAKAKGLYL- 246
            ||.|:.:||||:..|:||.||.|.||::.|:||:|.|::::.|.:||.||    ..||...|:.
  Rat    69 GISPSDLVRRARSKVFHLNCFTCMMCNKQLSTGEELYIIDENKFVCKEDYLSNSSVAKENSLHSA 133

  Fly   247 --------------------------------DGSLDGDQPN---KR--PRTTITAKQLETLKTA 274
                                            .||.:.|..|   ||  |||||.||||||||.|
  Rat   134 TTGSDPSLSPDSQDPSQDDAKDSESANVSDKEGGSNENDDQNLGAKRRGPRTTIKAKQLETLKAA 198

  Fly   275 YNNSPKPARHVREQLSQDTGLDMRVVQVWFQNRRAKEKRLKK-DAGRTRWSQYFRSMKGNCSPRT 338
            :..:|||.||:||||:|:|||:|||:||||||||:||:|:|: .|...|...:|||.: ...|..
  Rat   199 FAATPKPTRHIREQLAQETGLNMRVIQVWFQNRRSKERRMKQLSALGARRHAFFRSPR-RMRPLV 262

  Fly   339 DKFLDKDELKVDYDSFSHHDLSNDSYSTVNLGLDEGASPHSIRGSYMHGSSSPS-------QYPP 396
            |: |:..||           :.|              .|.|..|.|......|.       |.||
  Rat   263 DR-LEPGEL-----------IPN--------------GPFSFYGDYQSEYYGPGGNYDFFPQGPP 301

  Fly   397 SSRSPPPVGQGHTFGSYPDNIVYTNIDQAVGSSLHASKAHHRLHSSNNVSDL-----SNDSSPDQ 456
            ||::..||.......|.|.......:|       |....||....:...:|:     .:..||:.
  Rat   302 SSQAQTPVDLPFVPSSGPSGTPLGGLD-------HPLPGHHPSSEAQRFTDILAHPPGDSPSPEP 359

  Fly   457 GYPD---------FPPSPDSWLGDSGSTNTTSANNNANNNSSSSH 492
            ..|.         |.|||        ..::.|.|..|:..:..||
  Rat   360 SLPGPLHSMSAEVFGPSP--------PFSSLSVNGGASYGNHLSH 396

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lim3	NP_001260559.1	LIM1_Lhx3_Lhx4	122..173	CDD:188754	29/50 (58%)
		LIM2_Lhx3_Lhx4	181..236	CDD:188762	25/54 (46%)
		Homeobox	259..312	CDD:278475	39/52 (75%)
Lhx1	NP_665887.3	LIM1_Lhx1_Lhx5	4..55	CDD:188753	29/50 (58%)
		LIM2_Lhx1_Lhx5	63..118	CDD:188761	25/54 (46%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	128..189		12/60 (20%)
		Homeobox	183..237	CDD:395001	40/53 (75%)
		dnaA	<263..>382	CDD:237605	31/159 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	294..372		17/84 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910