DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Lim3 and ceh-14

DIOPT Version :9

Sequence 1:	NP_001260559.1	Gene:	Lim3 / 35184	FlyBaseID:	FBgn0002023	Length:	555	Species:	Drosophila melanogaster
Sequence 2:	NP_509273.1	Gene:	ceh-14 / 181012	WormBaseID:	WBGene00000438	Length:	351	Species:	Caenorhabditis elegans

Alignment Length:	389	Identity:	153/389 - (39%)
Similarity:	210/389 - (53%)	Gaps:	82/389 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    88 PHHNHLAVDQDDPNPELVLALISRNRALEATIPKCGGCHELILDRFILKVLERTWHAKCLQCSEC 152
            |..:...|:...||.|..:               |..|.:.|.|||:.||..|.:|:.||:||.|
Worm    29 PQEDFSNVNAGHPNNEEAI---------------CSLCDKKIRDRFVSKVNGRCYHSSCLRCSTC 78

  Fly   153 HGQLNDKCFARNGQLFCKEDFFKRYGTKCSACDMGIPPTQVVRRAQDNVYHLQCFLCAMCSRTLN 217
            ..:|...||.|...::|:..|:|::|||||:|:.||.|..|||:|.::|||::||.|.:|.|:|.
Worm    79 KDELGATCFLREDSMYCRAHFYKKFGTKCSSCNEGIVPDHVVRKASNHVYHVECFQCFICKRSLE 143

  Fly   218 TGDEFYLM-EDRKLICKRDYEEAKAKGLYLDGSLDGDQPNKRPRTTITAKQLETLKTAYNNSPKP 281
            ||:||||: :|.:|:||.|||:|:.|..   ..|:||..||||||||:||.|||||.||..|.||
Worm   144 TGEEFYLIADDARLVCKDDYEQARDKHC---NELEGDGSNKRPRTTISAKSLETLKQAYQTSSKP 205

  Fly   282 ARHVREQLSQDTGLDMRVVQVWFQNRRAKEKRLKKDAGRTRWSQYFRSMKGNCSPRTDKFLDKDE 346
            ||||||||:.:|||||||||||||||||||||||||||| ||....|:...:.||
Worm   206 ARHVREQLASETGLDMRVVQVWFQNRRAKEKRLKKDAGR-RWKSSNRAESDSNSP---------- 259

  Fly   347 LKVDYDSFSHHDLSNDSYSTVNLGLDEGASPHSIRGSYMHGS--SSPSQY----PPSSRSPPPVG 405
                .:|.:.   .:.:|..::..:|:|.     ..:|:..|  .:|.:|    .||: .|||:.
Worm   260 ----IESING---QSPNYLYLDHPMDDGN-----ESNYLFHSREQTPDKYYRNETPST-DPPPMH 311

  Fly   406 QGHTFGSYPDNIVYTNIDQAVGSSLHASKAHHRLHSSNNVSDLSNDSSPDQGYPDFPPSPDSWL 469
            .     :.| :::.||....             |..|.||.:|              |.|:|.|
Worm   312 M-----TTP-SVLTTNFSTP-------------LSLSTNVYNL--------------PPPESQL 342

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lim3	NP_001260559.1	LIM1_Lhx3_Lhx4	122..173	CDD:188754	20/50 (40%)
		LIM2_Lhx3_Lhx4	181..236	CDD:188762	29/55 (53%)
		Homeobox	259..312	CDD:278475	43/52 (83%)
ceh-14	NP_509273.1	LIM	48..103	CDD:278823	22/54 (41%)
		LIM2_Lhx3_Lhx4	107..163	CDD:188762	29/55 (53%)
		COG5576	<172..295	CDD:227863	70/145 (48%)
		Homeobox	183..236	CDD:278475	43/52 (83%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160159611
Domainoid	1	1.000	100	1.000	Domainoid score	I4422
eggNOG	1	0.900	-	-		E1_KOG4577
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S2759
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002911
OrthoInspector	1	1.000	-	-		oto18776
orthoMCL	1	0.900	-	-		OOG6_106440
Panther	1	1.100	-	-	LDO	PTHR24208
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2568
SonicParanoid	1	1.000	-	-		X1144
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	12	11.680