DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Lim3 and Lhx3

DIOPT Version :9

Sequence 1:	NP_001260559.1	Gene:	Lim3 / 35184	FlyBaseID:	FBgn0002023	Length:	555	Species:	Drosophila melanogaster
Sequence 2:	XP_038962056.1	Gene:	Lhx3 / 170671	RGDID:	71078	Length:	416	Species:	Rattus norvegicus

Alignment Length:	425	Identity:	202/425 - (47%)
Similarity:	243/425 - (57%)	Gaps:	84/425 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   106 LALISRNRALEATIPKCGGCHELILDRFILKVLERTWHAKCLQCSECHGQLNDKCFARNGQLFCK 170
            |.|:|      ..||.|.||.:.||||||||.|:|.||:|||:||:||..|.::||:|...::||
  Rat    11 LILVS------TEIPMCAGCDQHILDRFILKALDRHWHSKCLKCSDCHVPLAERCFSRGESVYCK 69

  Fly   171 EDFFKRYGTKCSACDMGIPPTQVVRRAQDNVYHLQCFLCAMCSRTLNTGDEFYLMEDRKLICKRD 235
            :|||||:||||:||.:|||||||||||||.||||.||.|.:|.|.|.||||||||||.:|:||.|
  Rat    70 DDFFKRFGTKCAACQLGIPPTQVVRRAQDFVYHLHCFACVVCKRQLATGDEFYLMEDSRLVCKAD 134

  Fly   236 YEEAKAKGLYLDGSLDGDQPNKRPRTTITAKQLETLKTAYNNSPKPARHVREQLSQDTGLDMRVV 300
            ||.||.:        :.:...||||||||||||||||:|||.|||||||||||||.:||||||||
  Rat   135 YETAKQR--------EAEATAKRPRTTITAKQLETLKSAYNTSPKPARHVREQLSSETGLDMRVV 191

  Fly   301 -----------------------------QVWFQNRRAKEKRLKKDAGRTRWSQYFRSMKGNCSP 336
                                         ||||||||||||||||||||.||.||||:||.:
  Rat   192 QVSARSRPPAPEGARAPREAGQPLTIPTPQVWFQNRRAKEKRLKKDAGRQRWGQYFRNMKRS--- 253

  Fly   337 RTDKFLDKDELKVDYDSFSHHDLSNDSYSTVNLGLDEG------------ASPHSIRGSYM--HG 387
            |.....|||.::...||.:....: |..|..::|...|            ..|....||:.  ||
  Rat   254 RGSSKSDKDSIQEGQDSDAEVSFT-DEPSMADMGTANGLYSSLGEPAPALGRPVGGLGSFTLEHG 317

  Fly   388 S-SSPSQY-----------PPSSRSPPPV-GQGHTFGS--YPDNIVYTNIDQAVGSSLHASKAHH 437
            . :.|.|:           |||..:|..: |......|  |||    ||:. .|.|.........
  Rat   318 GLAGPEQFRELRPGSPYGIPPSPAAPQSLPGPQPLLSSLVYPD----TNLG-LVPSGPPGGPPPM 377

  Fly   438 RLHSSNN-VSDLSNDSSPDQGYPDFPPSPDSWLGD 471
            |:.:.|. .||||.:||  .||||||.||.|||.:
  Rat   378 RVLAGNGPSSDLSTESS--GGYPDFPASPASWLDE 410

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lim3	NP_001260559.1	LIM1_Lhx3_Lhx4	122..173	CDD:188754	28/50 (56%)
		LIM2_Lhx3_Lhx4	181..236	CDD:188762	39/54 (72%)
		Homeobox	259..312	CDD:278475	48/81 (59%)
Lhx3	XP_038962056.1	LIM1_Lhx3b	18..72	CDD:188851	30/53 (57%)
		LIM2_Lhx3_Lhx4	80..135	CDD:188762	39/54 (72%)
		Homeobox	150..233	CDD:395001	49/82 (60%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	111	1.000	Domainoid score	I6156
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H7814
Inparanoid	1	1.050	359	1.000	Inparanoid score	I2144
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1174754at2759
OrthoFinder	1	1.000	-	-		FOG0002911
OrthoInspector	1	1.000	-	-		otm46364
orthoMCL	1	0.900	-	-		OOG6_106440
Panther	1	1.100	-	-	LDO	PTHR24208
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1144
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	12	11.970