DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Lim3 and Lhx5

DIOPT Version :9

Sequence 1:	NP_001260559.1	Gene:	Lim3 / 35184	FlyBaseID:	FBgn0002023	Length:	555	Species:	Drosophila melanogaster
Sequence 2:	NP_620605.1	Gene:	Lhx5 / 124451	RGDID:	71079	Length:	402	Species:	Rattus norvegicus

Alignment Length:	437	Identity:	151/437 - (34%)
Similarity:	212/437 - (48%)	Gaps:	110/437 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   122 CGGCHELILDRFILKVLERTWHAKCLQCSECHGQLNDKCFARNGQLFCKEDFFKRYGTKCSACDM 186
            |.||...|||||:|.||:|.||.||:||.||...|::|||:|.|:|:||.|||:|:||||:.|..
  Rat     5 CAGCERPILDRFLLNVLDRAWHIKCVQCCECKTNLSEKCFSREGKLYCKNDFFRRFGTKCAGCAQ 69

  Fly   187 GIPPTQVVRRAQDNVYHLQCFLCAMCSRTLNTGDEFYLMEDRKLICKRDYEEAKAKGLYLDGSLD 251
            ||.|:.:||:|:..|:||.||.|.:|::.|:||:|.|::::.|.:||.||..:.:   ..:|||:
  Rat    70 GISPSDLVRKARSKVFHLNCFTCMVCNKQLSTGEELYVIDENKFVCKDDYLSSSS---LKEGSLN 131

  Fly   252 G------------------DQP------------------------NKR--PRTTITAKQLETLK 272
            .                  |.|                        .||  |||||.||||||||
  Rat   132 SVSSCTDRSLSPDLQDPLQDDPKETDNSTSSDKETANNENEEQNSGTKRRGPRTTIKAKQLETLK 196

  Fly   273 TAYNNSPKPARHVREQLSQDTGLDMRVVQVWFQNRRAKEKRLKK-DAGRTRWSQYFRSMKGNCSP 336
            .|:..:|||.||:||||:|:|||:|||:||||||||:||:|:|: .|...|...:||      ||
  Rat   197 AAFAATPKPTRHIREQLAQETGLNMRVIQVWFQNRRSKERRMKQLSALGARRHAFFR------SP 255

  Fly   337 RTDK----FLDKDELKVDYDSFSHHDLSNDSYSTVNLGLDEGASPHSIRGSYMHGSSSPSQYPPS 397
            |..:    .||:.|:........:.|..:|.|           :|......:.||..|.:|.|..
  Rat   256 RRMRPLGGRLDESEMLGSTPYTYYGDYQSDYY-----------APGGNYDFFAHGPPSQAQSPAD 309

  Fly   398 SRSPPPVGQGHT-FGSYPDNIVYTNIDQAVGSSLHASKAHHRLHSSNN--VSDL---SNDSSPDQ 456
            |......|.|.| .|:....:...                   |.::|  .:|:   .:..||:.
  Rat   310 SSFLAASGPGSTPLGALEPPLAGP-------------------HGADNPRFTDMISHPDTPSPEP 355

  Fly   457 GYP--------------DFPPSPDSWLGDSGSTNTTSANNNANNNSS 489
            |.|              ..||.|.|  |.||.:...|..|...|.::
  Rat   356 GLPGALHPMPGEVFSGGPSPPFPMS--GTSGYSGPLSHPNPELNEAA 400

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lim3	NP_001260559.1	LIM1_Lhx3_Lhx4	122..173	CDD:188754	29/50 (58%)
		LIM2_Lhx3_Lhx4	181..236	CDD:188762	23/54 (43%)
		Homeobox	259..312	CDD:278475	39/52 (75%)
Lhx5	NP_620605.1	LIM1_Lhx1_Lhx5	5..56	CDD:188753	29/50 (58%)
		LIM2_Lhx1_Lhx5	64..119	CDD:188761	23/54 (43%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	124..186		9/64 (14%)
		Homeobox	183..237	CDD:395001	40/53 (75%)
		PHA03378	<247..>392	CDD:223065	38/182 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	298..402		27/124 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910