DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10700 and aif1

DIOPT Version :9

Sequence 1:	NP_609942.1	Gene:	CG10700 / 35183	FlyBaseID:	FBgn0032754	Length:	539	Species:	Drosophila melanogaster
Sequence 2:	NP_001342910.1	Gene:	aif1 / 3361554	PomBaseID:	SPAC26F1.14c	Length:	611	Species:	Schizosaccharomyces pombe

Alignment Length:	535	Identity:	162/535 - (30%)
Similarity:	267/535 - (49%)	Gaps:	63/535 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 ILLVKQSGILRAVGAMCPHRGAPLAKGVL-SRNRVRCPWHGVCFNLETGDIENFPGLDSLPCHRV 97
            :|||:......|....|.|.||||||||: |...:.|||||.|||..|||:|:.|.:.:|....|
pombe    81 VLLVRARNTYFATAGKCSHYGAPLAKGVVTSDGHIVCPWHGACFNAATGDVEDTPAIAALRTFPV 145

  Fly    98 NVDSRGQVLVQVKRSYLLRHARIKSMACRNWQDQR----------------HFVVVGGGPSGAVC 146
            ..:..|.:.::|:.......:.::...|  |:::.                |..::|||...:|.
pombe   146 TEEGDGSLWIEVEDKNDNGASVLQPEGC--WRNKATEVYNKGSVETEVTAPHVCIIGGGKGASVA 208

  Fly   147 VETLRQEGFTGRLTLVCGEKHLPYDRTRI-MNLLNTYTKNLALREEQFYKDYGIEMQLGVSAERL 210
            .|.||::.|.|::|:...|..:||||.:: .:||:..:| ||||.:::|.|..|.........::
pombe   209 AEYLREKNFKGKITIFTREDEVPYDRPKLSKSLLHDISK-LALRSKEYYDDLDISFHFNTDVTKI 272

  Fly   211 DTNCNTLHCTNGK--TFPYDKIYIATGYSAVTPN---IPGVHLKNVKVIRNIGDARSIFKMV--- 267
            |.....::|.:.:  |..|.|:.:|||..   ||   |||:..|||.::|:|.||..:..:.
pombe   273 DLAEKKIYCGSDEKPTESYTKLILATGGE---PNKLPIPGLDSKNVYLLRSIADASKLAAVTTEA 334

  Fly   268 -DKSTQVVCLGSSFMAVEATANLVSRARSVTLVARQNVPFKSTLGELIGQRILKLLEENKVDLRM 331
             ||. .:|.:||||:.:|..  :|.:..:|:::..:::||:..:|:.:|..:..|.|:|.:...:
pombe   335 GDKK-NIVIIGSSFIGLELA--VVLKDHNVSVIGMESIPFEKVMGKEVGTALKALHEQNGIAFYL 396

  Fly   332 SSGI--IRILGNSRGEVVAVKLLDNSRIPCNLLILGTGCQCNTDFLQRSGININPNGSVDVNDFL 394
            .:.|  ::...|...:...:.|.|...||.:::||..|.:.|..:| .:.:::..:|.|.|::..
pombe   397 ENSIKEVKTSSNDSSKAEHIVLKDGQSIPADVVILAAGVKPNLRYL-GNAVSLEKDGGVKVDEHC 460

  Fly   395 QT-KVRNVYVGGDIANAYILG----GFPDRVNISHYGLAQYHGRIAA-----LNMSGHIAKLEAI 449
            :. ...:||..||||:|...|    |......|.|:.:|...||:||     .|.:|:..| ...
pombe   461 RVLGAEDVYAVGDIAHAPFAGLPSSGEKSHTRIEHWDVAGNLGRVAADHILFGNKAGYTTK-SFT 524

  Fly   450 PFFYTVIFGRAFRSAGYGP---FKDVVIDGSLEDLQFVAYFFDDYDKVTAVASCGRDPMVAQFAE 511
            |:|::. .|:..|..|...   |.||||.|||.|.:| |.||...:||..|.|..:||:|:|.|.
pombe   525 PYFWSA-QGKQLRYCGNNAAEGFDDVVIQGSLSDYKF-ACFFTKGEKVVGVCSIMKDPVVSQCAR 587

  Fly   512 LV--------SQGKE 518
            |.        ||.||
pombe   588 LFIKDAMPSKSQLKE 602

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10700	NP_609942.1	Rieske_AIFL_N	10..106	CDD:239560	31/72 (43%)
		Pyr_redox_2	135..414	CDD:285266	83/291 (29%)
		Pyr_redox	273..350	CDD:278498	17/78 (22%)
		COG3393	336..>508	CDD:225928	57/184 (31%)
		Reductase_C	464..527	CDD:291425	28/66 (42%)
aif1	NP_001342910.1	Rieske_AIFL_N	58..154	CDD:239560	31/72 (43%)
		Pyr_redox_2	194..499	CDD:311792	88/312 (28%)
		Reductase_C	526..>576	CDD:317198	20/51 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	174	1.000	Domainoid score	I867
eggNOG	1	0.900	-	-		E1_COG0446
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	271	1.000	Inparanoid score	I708
OMA	1	1.010	-	-		QHG58553
OrthoFinder	1	1.000	-	-		FOG0001279
OrthoInspector	1	1.000	-	-		otm47043
orthoMCL	1	0.900	-	-		OOG6_100481
Panther	1	1.100	-	-	O	PTHR43557
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R33
SonicParanoid	1	1.000	-	-		X1666
TreeFam	1	0.960	-	-
	13	12.860