DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10700 and AIF

DIOPT Version :9

Sequence 1:	NP_609942.1	Gene:	CG10700 / 35183	FlyBaseID:	FBgn0032754	Length:	539	Species:	Drosophila melanogaster
Sequence 2:	NP_722765.2	Gene:	AIF / 33390	FlyBaseID:	FBgn0031392	Length:	739	Species:	Drosophila melanogaster

Alignment Length:	407	Identity:	87/407 - (21%)
Similarity:	162/407 - (39%)	Gaps:	97/407 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   134 FVVVGGGPSGAVCVETLRQEGFTGRLTLVCGEKHLPYDRTRIMNLLNTYTKN------------- 185
            ::::|||.:.......::....|.::.::..|...||.|..:...| .||.|
  Fly   257 YLIIGGGTAAFSAFRAIKSNDATAKVLMISNEFRKPYMRPPLSKEL-WYTPNPNEDPIKDYRFKQ 320

  Fly   186 -------LALREEQFYKD---------YGIEMQLGVSAERLDTNCNTLHCTNGKTFPYDKIYIAT 234
                   |....::|:.|         .||.:..|.|.:::|.....:...:|....||:..|||
  Fly   321 WTGSERSLFFEPDEFFIDPEDLDDNANGGIAVAQGFSVKKVDAQKRIVTLNDGYEISYDECLIAT 385

  Fly   235 GYSAVTPNIPGVH------LKNVKVIRNIGDARSIFKMVDKSTQVVCLGSSFMAVEATANLVSRA 293
            |  ....|:|.:.      |:.|.|.|...|...:.|:..:...:..:|:.|:..|...:|...:
  Fly   386 G--CAPKNLPMLRDAPPSVLEKVMVYRTPDDFDRLRKLAAEKRSITIVGNGFIGSELACSLAHYS 448

  Fly   294 RSVTLVARQNVPFKSTLGELIGQRILKLLEEN----KV---------DLRMSSGIIRILGNS--- 342
            |                 |..|.::.::.:||    ||         ..:|.:..:.::.|:
  Fly   449 R-----------------ENNGGKVYQVFQENANMSKVLPNYLSRWTTAKMEAQGVCVIPNASIR 496

  Fly   343 ---RGEV-VAVKLLDNSRIPCNLLILGTGCQCNTDFLQRSGININPN-GSVDVNDFLQTKVRNVY 402
               |.|. :.::|.:...:..:::::..||..|||....|.:.::.: |...||..|:.: ||:|
  Fly   497 SAVRDETNLKLELNNGMTLMSDVVVVCVGCTPNTDLAGPSRLEVDRSLGGFVVNAELEAR-RNLY 560

  Fly   403 VGGDIANAY--ILGGFPDRVNISHYGLAQYHGRIAALNMSGHIAKLEAIPFFYTVIF----GRAF 461
            |.||.:..:  :||    |..:.|:..:...||:|..||:|  ||.   |:.:..:|    |...
  Fly   561 VAGDASCFFDPLLG----RRRVEHHDHSVVSGRLAGENMTG--AKK---PYQHQSMFWSDLGPEI 616

  Fly   462 RSAGYGPFKDVVIDGSL 478
            ...|.|     ::|.||
  Fly   617 GYEGIG-----LVDSSL 628

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10700	NP_609942.1	Rieske_AIFL_N	10..106	CDD:239560
		Pyr_redox_2	135..414	CDD:285266	67/336 (20%)
		Pyr_redox	273..350	CDD:278498	15/96 (16%)
		COG3393	336..>508	CDD:225928	40/157 (25%)
		Reductase_C	464..527	CDD:291425	5/15 (33%)
AIF	NP_722765.2	Pyr_redox_2	257..573	CDD:285266	67/336 (20%)
		Pyr_redox	427..512	CDD:278498	16/101 (16%)
		AIF_C	591..720	CDD:291391	14/48 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45464293
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0446
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR43557
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.840