DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10700 and Aifm3

DIOPT Version :9

Sequence 1:	NP_609942.1	Gene:	CG10700 / 35183	FlyBaseID:	FBgn0032754	Length:	539	Species:	Drosophila melanogaster
Sequence 2:	XP_008767097.1	Gene:	Aifm3 / 303786	RGDID:	1306028	Length:	608	Species:	Rattus norvegicus

Alignment Length:	524	Identity:	194/524 - (37%)
Similarity:	302/524 - (57%)	Gaps:	22/524 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 VCHKLEVQENEMRQVDASGIPSILLVKQSGILRAVGAMCPHRGAPLAKGVLSRNRVRCPWHGVCF 76
            |||..:::..:||:|:. |...:||||.:|...|:|..|||.||||.||||||.||||||||.||
  Rat    72 VCHVKDLENGQMREVEL-GWGKVLLVKDNGEFHALGHKCPHYGAPLVKGVLSRGRVRCPWHGACF 135

  Fly    77 NLETGDIENFPGLDSLPCHRVNVDSRGQVLVQVKRSYLLRHARIKSMA-CRN---WQDQRHFVVV 137
            |:.|||:|:|||||||...:|.:: :.:|.|:..:..|....|.|.|| |.:   .....:.::|
  Rat   136 NIGTGDLEDFPGLDSLHKFQVKIE-KEKVTVRASKQALQLQRRTKVMAKCISPSAGHSSTNVLIV 199

  Fly   138 GGGPSGAVCVETLRQEGFTGRLTLVCGEKHLPYDRTRIMNLLNTYTKNLALREEQFYKDYGIEMQ 202
            |.|.:|.||.||||||||:.|:.|...::||||||.::...|:...:.||||.::|::.|||||.
  Rat   200 GAGAAGLVCAETLRQEGFSDRIVLCTLDRHLPYDRAKLSKSLDAQPEQLALRPKEFFRAYGIEML 264

  Fly   203 LGVSAERLDTNCNTLHCTNGKTFPYDKIYIATGYSAVTPNIPGVHLKNVKVIRNIGDARSIFKMV 267
            .......:|.....:...:|....|.|:.:|.|.|..|....|..::||..||...||..:.::.
  Rat   265 TEAQVVTVDVRNKKVVFKDGFKLEYSKLLLAPGSSPKTLTCKGKDIENVFTIRTPEDANRVLRLA 329

  Fly   268 DKSTQVVCLGSSFMAVEATANLVSRARSVTLVARQNVPFKSTLGELIGQRILKLLEENKVDLRMS 332
             :....|.:|:.|:.:|..|.|..:|.||::|..:..||:..|||.:|:.::|:.|.|:|...|.
  Rat   330 -RGRNAVVVGAGFLGMEVAAYLTEKAHSVSVVELEETPFRRFLGERVGRALMKMFENNRVKFYMQ 393

  Fly   333 SGIIRILGNSRGEVVAVKLLDNSRIPCNLLILGTGCQCNTDFLQRSGININPNGSVDVNDFLQTK 397
            :.:.. |....|::..|.|..:..:..::.::|.|....|.||::|||.::..|.:.||..:||.
  Rat   394 TEVSE-LRAQEGKLQEVVLKSSKVLRADVCVVGIGAVPATGFLRQSGIGLDSRGFIPVNKMMQTN 457

  Fly   398 VRNVYVGGDIANAYILGGFP------DRVNISHYGLAQYHGRIAALNMSGHIAKLEAIPFFYTVI 456
            :..|:..||...      ||      .:|||.|:.:|...||:||.||....|::..:|:.:|.:
  Rat   458 IPGVFAAGDAVT------FPLAWRNNRKVNIPHWQMAHAQGRVAAQNMLAQEAEINTVPYLWTAM 516

  Fly   457 FGRAFRSAGYGP-FKDVVIDGSLEDLQFVAYFFDDYDKVTAVASCGRDPMVAQFAELVSQGKELC 520
            ||::.|.||||. |.||:|.|.||:|:||| |:...|:|.||||...||:|::.||:::.|:.:.
  Rat   517 FGKSLRYAGYGEGFDDVIIQGDLEELKFVA-FYTKGDEVIAVASMNYDPIVSKVAEVLASGRAIR 580

  Fly   521 RCQI 524
            :.::
  Rat   581 KREV 584

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10700	NP_609942.1	Rieske_AIFL_N	10..106	CDD:239560	50/93 (54%)
		Pyr_redox_2	135..414	CDD:285266	89/278 (32%)
		Pyr_redox	273..350	CDD:278498	23/76 (30%)
		COG3393	336..>508	CDD:225928	64/178 (36%)
		Reductase_C	464..527	CDD:291425	28/62 (45%)
Aifm3	XP_008767097.1	Rieske_AIFL_N	70..163	CDD:239560	50/92 (54%)
		Pyr_redox_2	194..492	CDD:400379	96/305 (31%)
		Reductase_C	511..>561	CDD:405449	26/50 (52%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	187	1.000	Domainoid score	I3238
eggNOG	1	0.900	-	-		E1_COG0446
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	366	1.000	Inparanoid score	I2094
OMA	1	1.010	-	-		QHG58553
OrthoDB	1	1.010	-	-		D183405at33208
OrthoFinder	1	1.000	-	-		FOG0001279
OrthoInspector	1	1.000	-	-		otm44669
orthoMCL	1	0.900	-	-		OOG6_100481
Panther	1	1.100	-	-	O	PTHR43557
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1666
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	14	13.840