DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10700 and Aifm1

DIOPT Version :9

Sequence 1:	NP_609942.1	Gene:	CG10700 / 35183	FlyBaseID:	FBgn0032754	Length:	539	Species:	Drosophila melanogaster
Sequence 2:	NP_036149.1	Gene:	Aifm1 / 26926	MGIID:	1349419	Length:	612	Species:	Mus musculus

Alignment Length:	427	Identity:	98/427 - (22%)
Similarity:	178/427 - (41%)	Gaps:	91/427 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   134 FVVVGGGPSGAVCVETLRQEGFTGRLTLVCGEKHLPYDRTRIMNLL-----NTYTKNLALRE--- 190
            |:::|||.:......::|......|:.:|..:..|||.|..:...|     ...||.|..|:
Mouse   133 FLLIGGGTAAFAAARSIRARDPGARVLIVSEDPELPYMRPPLSKELWFSDDPNVTKTLQFRQWNG 197

  Fly   191 ---------EQFY---------KDYGIEMQLGVSAERLDTNCNTLHCTNGKTFPYDKIYIATG-- 235
                     ..||         ::.|:.:..|.....||...|.:...:|....::|..||||
Mouse   198 KERSIYFQPPSFYVSAQDLPNIENGGVAVLTGKKVVHLDVRGNMVKLNDGSQITFEKCLIATGGT 262

  Fly   236 ---YSAVTPNIPGVHLKN-VKVIRNIGDARSIFKMVDKSTQVVCLGSSFMAVEATANLVSRARSV 296
               .||:  :..|..:|: ..:.|.|||.|::.|:..:...:..:|..|:..|....|..::::.
Mouse   263 PRSLSAI--DRAGAEVKSRTTLFRKIGDFRALEKISREVKSITVIGGGFLGSELACALGRKSQAS 325

  Fly   297 TLVARQNVPFKSTLGELIGQRI----LKLLEENKVDLRMSSGIIRILGNSRGEVVAVKLLDNSRI 357
            .:...|..|.|..:|:::.|.:    ::.::...|.: |.:.|::.:|.|.|.:: :||.|..::
Mouse   326 GIEVIQLFPEKGNMGKILPQYLSNWTMEKVKREGVKV-MPNAIVQSVGVSGGRLL-IKLKDGRKV 388

  Fly   358 PCNLLILGTGCQCNTDFLQRSGININPN-GSVDVNDFLQTKVRNVYVGGDIANAY--ILGGFPDR 419
            ..:.::...|.:.|.:..:..|:.|:.: |...||..||.: .|::|.||.|..|  .||    |
Mouse   389 ETDHIVTAVGLEPNVELAKTGGLEIDSDFGGFRVNAELQAR-SNIWVAGDAACFYDIKLG----R 448

  Fly   420 VNISHYGLAQYHGRIAALNMSGHIAKLEAIPFFYTVIFGRAFRSAGYGPFKDV------VIDGSL 478
            ..:.|:..|...||:|..||:|     .|.|:::..:|.     :..||  ||      ::|.||
Mouse   449 RRVEHHDHAVVSGRLAGENMTG-----AAKPYWHQSMFW-----SDLGP--DVGYEAIGLVDSSL 501

  Fly   479 EDLQFVAYFFDDYDKVTAVASCGRDPMVAQFAELVSQ 515
                                     |.|..||:..:|
Mouse   502 -------------------------PTVGVFAKATAQ 513

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10700	NP_609942.1	Rieske_AIFL_N	10..106	CDD:239560
		Pyr_redox_2	135..414	CDD:285266	71/317 (22%)
		Pyr_redox	273..350	CDD:278498	15/80 (19%)
		COG3393	336..>508	CDD:225928	44/180 (24%)
		Reductase_C	464..527	CDD:291425	12/58 (21%)
Aifm1	NP_036149.1	Mitochondrial localization signal. /evidence=ECO:0000305\|PubMed:9989411	1..30
		vWFA	<47..121	CDD:294047
		Mitochondrial localization signal. /evidence=ECO:0000305\|PubMed:9989411	62..88
		FAD-dependent oxidoreductase	133..482		85/362 (23%)
		Pyr_redox_2	149..446	CDD:285266	68/301 (23%)
		Pyr_redox	301..385	CDD:278498	17/85 (20%)
		Nuclear localization signal. /evidence=ECO:0000255	445..450		3/8 (38%)
		AIF_C	464..592	CDD:291391	19/87 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	512..551		1/2 (50%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0446
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810