Protein Alignment CG10700 and AIFM3

DIOPT Version :9

• Sequence 1: NP_609942.1
• Gene: CG10700 / 35183
• FlyBaseID: FBgn0032754
• Length: 539
• Species: Drosophila melanogaster
• Sequence 2: NP_001373743.1
• Gene: AIFM3 / 150209
• HGNCID: 26398
• Length: 605
• Species: Homo sapiens
• Alignment Length: 541
• Identity: 200/541 - (36%)
• Similarity: 310/541 - (57%)
• Gaps: 28/541 - (5%)

  Fly    12 VCHKLEVQENEMRQVDASGIPSILLVKQSGILRAVGAMCPHRGAPLAKGVLSRNRVRCPWHGVCF 76
            |||..:::..:||:|:. |...:||||.:|...|:|..|||.||||.||||||.||||||||.||
Human    72 VCHVKDLENGQMREVEL-GWGKVLLVKDNGEFHALGHKCPHYGAPLVKGVLSRGRVRCPWHGACF 135

  Fly    77 NLETGDIENFPGLDSLPCHRVNVDSRGQVLVQVKRSYLLRHARIKSMA-C----RNWQDQRHFVV 136
            |:.|||:|:|||||||...:|.:: :.:|.|:..:..|....|.|.|| |    ..:....:.::
Human   136 NISTGDLEDFPGLDSLHKFQVKIE-KEKVYVRASKQALQLQRRTKVMAKCISPSAGYSSSTNVLI 199

  Fly   137 VGGGPSGAVCVETLRQEGFTGRLTLVCGEKHLPYDRTRIMNLLNTYTKNLALREEQFYKDYGIEM 201
            ||.|.:|.||.||||||||:.|:.|...::||||||.::...|:|..:.||||.::|::.||||:
Human   200 VGAGAAGLVCAETLRQEGFSDRIVLCTLDRHLPYDRPKLSKSLDTQPEQLALRPKEFFRAYGIEV 264

  Fly   202 QLGVSAERLDTNCNTLHCTNGKTFPYDKIYIATGYSAVTPNIPGVHLKNVKVIRNIGDARSIFKM 266
            ........:|.....:...:|....|.|:.:|.|.|..|.:..|..::||..||...||..:.::
Human   265 LTEAQVVTVDVRTKKVVFKDGFKLEYSKLLLAPGSSPKTLSCKGKEVENVFTIRTPEDANRVVRL 329

  Fly   267 VDKSTQVVCLGSSFMAVEATANLVSRARSVTLVARQNVPFKSTLGELIGQRILKLLEENKVDLRM 331
            . :...||.:|:.|:.:|..|.|..:|.||::|..:..||:..|||.:|:.::|:.|.|:|...|
Human   330 A-RGRNVVVVGAGFLGMEVAAYLTEKAHSVSVVELEETPFRRFLGERVGRALMKMFENNRVKFYM 393

  Fly   332 SSGIIRILGNSRGEVVAVKLLDNSRIPCNLLILGTGCQCNTDFLQRSGININPNGSVDVNDFLQT 396
            .:.:..:.| ..|::..|.|..:..:..::.::|.|....|.||::|||.::..|.:.||..:||
Human   394 QTEVSELRG-QEGKLKEVVLKSSKVVRADVCVVGIGAVPATGFLRQSGIGLDSRGFIPVNKMMQT 457

  Fly   397 KVRNVYVGGDIANAYILGGFP------DRVNISHYGLAQYHGRIAALNMSGHIAKLEAIPFFYTV 455
            .|..|:..||...      ||      .:|||.|:.:|...||:||.||....|::..:|:.:|.
Human   458 NVPGVFAAGDAVT------FPLAWRNNRKVNIPHWQMAHAQGRVAAQNMLAQEAEMSTVPYLWTA 516

  Fly   456 IFGRAFRSAGYGP-FKDVVIDGSLEDLQFVAYFFDDYDKVTAVASCGRDPMVAQFAELVSQGKEL 519
            :||::.|.||||. |.||:|.|.||:|:||| |:...|:|.||||...||:|::.||:::.|:.:
Human   517 MFGKSLRYAGYGEGFDDVIIQGDLEELKFVA-FYTKGDEVIAVASMNYDPIVSKVAEVLASGRAI 580

  Fly   520 CRCQIV-----DPKGRNYWLT 535
            .:.::.     ...|...|||
Human   581 RKREVELFVLHSKTGDMSWLT 601

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG10700	NP_609942.1	Rieske_AIFL_N	10..106	CDD:239560	50/93 (54%)
		Pyr_redox_2	135..414	CDD:285266	91/278 (33%)
		Pyr_redox	273..350	CDD:278498	24/76 (32%)
		COG3393	336..>508	CDD:225928	65/178 (37%)
		Reductase_C	464..527	CDD:291425	28/68 (41%)
AIFM3	NP_001373743.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	22..45
		Rieske_AIFL_N	70..164	CDD:239560	50/93 (54%)
		Pyr_redox_2	195..493	CDD:400379	98/305 (32%)
		Reductase_C	512..>562	CDD:405449	26/50 (52%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	186	1.000	Domainoid score	I3362
eggNOG	1	0.900	-	-		E1_COG0446
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	366	1.000	Inparanoid score	I2167
Isobase	1	0.950	-	0	Normalized mean entropy	S3886
OMA	1	1.010	-	-		QHG58553
OrthoDB	1	1.010	-	-		D183405at33208
OrthoFinder	1	1.000	-	-		FOG0001279
OrthoInspector	1	1.000	-	-		otm40528
orthoMCL	1	0.900	-	-		OOG6_100481
Panther	1	1.100	-	-	O	PTHR43557
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R33
SonicParanoid	1	1.000	-	-		X1666
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	15	14.820