Protein Alignment CG10702 and ROS1

DIOPT Version :9

• Sequence 1: NP_001188841.1
• Gene: CG10702 / 35181
• FlyBaseID: FBgn0032752
• Length: 946
• Species: Drosophila melanogaster
• Sequence 2: XP_011534351.1
• Gene: ROS1 / 6098
• HGNCID: 10261
• Length: 2357
• Species: Homo sapiens
• Alignment Length: 880
• Identity: 163/880 - (18%)
• Similarity: 273/880 - (31%)
• Gaps: 312/880 - (35%)

  Fly   127 VFPKLVAIQR-GQVYI--------GSCPKLCSIGRVNWDLLTLTRGENNIIMVNKNCSTPVCSGC 182
            :.||||.... |.::|        .||.|.|          ....|:...:....|.|.|...||
Human     7 LIPKLVNFATLGCLWISVVQCTVLNSCLKSC----------VTNLGQQLDLGTPHNLSEPCIQGC 61

  Fly   183 SSSHCWSN---HYCQRSINENVANPKANINAC-HEECLGGCKNNS--------------SSPADC 229
               |.|::   ..|....|:..|      ..| .|.|..||.:..              ::|...
Human    62 ---HFWNSVDQKNCALKCNDTYA------TVCERESCEVGCSSAEGAYEEEVLENADLPTAPFAS 117

  Fly   230 SV--------CRGLSDDGVCVKSCPKDKYVME-NYQR-----CYTKAECVLKHGYVIS------- 273
            |:        .:..:..||        ||::: .|.:     .|||.  |.:..||:.
Human   118 SIGSHNMTLRWKSANFSGV--------KYIIQWKYAQLLGSWTYTKT--VSRPSYVVKPLHPFTE 172

  Fly   274 ---------GSQCVAFCP--SGYKT-------------NNRSECVLCSPDEACISFCTPEWPGKA 314
                     .:|...:.|  ..|:|             |..|.    |||...:|:..|::||..
Human   173 YIFRVVWIFTAQLQLYSPPSPSYRTHPHGVPETAPLIRNIESS----SPDTVEVSWDPPQFPGGP 233

  Fly   315 FTVYNLADAENLRGCQIFNGSLVITIRNKVNETQLYQSFTSMREVRGHVKVYRSSQLRSLQFLRN 379
            ...|||                                    |.:..:.|:...:|..|.||.
Human   234 ILGYNL------------------------------------RLISKNQKLDAGTQRTSFQFY-- 260

  Fly   380 LERVHGDPLENRHYSFILYDNKELSE-------LWTPSRQLEFMEGGMFMHRNNKLCNRRMREFQ 437
                  ..|.|..|.|.:....|:.|       :.|.|..::..|..:|:.|...|..|.::...
Human   261 ------STLPNTIYRFSIAAVNEVGEGPEAESSITTSSSAVQQEEQWLFLSRKTSLRKRSLKHLV 319

  Fly   438 NAVTHDRALDSLQTNDQEVQCSPLKLQLYVQKRTHRSVKLSWLK--SQTSQKIELIHRPLLPGKL 500
            :. .|...||::..|...:.....:..:|..:.|     |.|.|  :..|...:|        ::
Human   320 DE-AHCLRLDAIYHNITGISVDVHQQIVYFSEGT-----LIWAKKAANMSDVSDL--------RI 370

  Fly   501 YHEESELDAPICTRINW--KRRLLFPDDLI-----ENGTHYLFDLDDLQPDTRYVVLLRTFGNDE 558
            ::..|.|.:.|  .|:|  :|.....|:|:     ||.:    :::::.|.           :..
Human   371 FYRGSGLISSI--SIDWLYQRMYFIMDELVCVCDLENCS----NIEEITPP-----------SIS 418

  Fly   559 AHEAYEARSELTYV---------QTELDIPKPPLLELVKKTDSSLTVQMASHDHVS--------- 605
            |.:...|.|...||         :.:|.:|.....|.|:..:|......|......
Human   419 APQKIVADSYNGYVFYLLRDGIYRADLPVPSGRCAEAVRIVESCTLKDFAIKPQAKRIIYFNDTA 483

  Fly   606 --FLLTVFELSDDQDYIEQRNYCHQPSYVWQDMDGPRWMAYEDYDDCCAQKAEQFEDSRFIADMR 668
              |:.|..:.|.....:.:..:....|:..::.|    ....|......|.|..|.:  ||..
Human   484 QVFMSTFLDGSASHLILPRIPFADVKSFACENND----FLVTDGKVIFQQDALSFNE--FIVG-- 540

  Fly   669 EQYRCTLDDREQCRRLAHTEV----------SLPQLR-LPGNTTEYEL-----KALHRYRLYALQ 717
                |.         |:|.|.          |..||. |||...|..:     :||.:::..||.
Human   541 ----CD---------LSHIEEFGFGNLVIFGSSSQLHPLPGRPQELSVLFGSHQALVQWKPPALA 592

  Fly   718 LQACNPLGCSSHTTLY-----GRTNYTMGADLLTQ-------LY------ACHIPEMD-----KY 759
            :.| |.:..|....|:     ...|:|....:.||       ::      ..::||:.     |.
Human   593 IGA-NVILISDIIELFELGPSAWQNWTYEVKVSTQDPPEVTHIFLNISGTMLNVPELQSAMKYKV 656

  Fly   760 IMRFEEPKKP--------------------------NGLVTNYVIHF-RNNFSQTHVGCVTRMD- 796
            .:|...||:|                          :||.:..:..| ...|..:.:|.|:.||
Human   657 SVRASSPKRPGPWSEPSVGTTLVPASEPPFIMAVKEDGLWSKPLNSFGPGEFLSSDIGNVSDMDW 721

  Fly   797 -------HQSAGYMYVKQINITFTECAVRVHSLAG 824
                   ..:.|.::|..:|.|.......:.|:||
Human   722 YNNSLYYSDTKGDVFVWLLNGTDISENYHLPSIAG 756

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG10702	NP_001188841.1	Recep_L_domain	47..159	CDD:279382	10/40 (25%)
		Furin-like	171..297	CDD:279142	34/188 (18%)
		FU	210..258	CDD:238021	12/76 (16%)
		Recep_L_domain	328..441	CDD:279382	19/119 (16%)
ROS1	XP_011534351.1	None

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	2	1.870