DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10702 and Insrr

DIOPT Version :9

Sequence 1:	NP_001188841.1	Gene:	CG10702 / 35181	FlyBaseID:	FBgn0032752	Length:	946	Species:	Drosophila melanogaster
Sequence 2:	NP_071548.2	Gene:	Insrr / 60663	RGDID:	67399	Length:	1300	Species:	Rattus norvegicus

Alignment Length:	925	Identity:	249/925 - (26%)
Similarity:	407/925 - (44%)	Gaps:	151/925 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 LMFLALYVPCAESKKEHECTSIDIRNECKNMHLLDNCTVVTGYVMITLITIEQRCNFSEYSYPLL 76
            ||.|.....|.::.:  .|.|:|||:|...:..|:||:||.|::.|.|:......:|...|:|.|
  Rat    14 LMSLLSLGSCLDTLE--VCPSLDIRSEVTELRRLENCSVVEGHLQILLMFAATGEDFRGLSFPRL 76

  Fly    77 TEITEFMIFTDVRGLVNITEMFPHLTVIRGRRLFLNYALGVTNMHELEQLVFPKLVAIQRGQVYI 141
            |::|::::...|.||.::.::||:|.||||.||||.|||.:..|..|..:..|.|.|:.||.|.:
  Rat    77 TQVTDYLLLFRVYGLESLRDLFPNLAVIRGARLFLGYALIIFEMPHLRDIGLPSLGAVLRGAVRV 141

  Fly   142 GSCPKLCSIGRVNWDLLTLTRGENNII--MVNKNCSTPVCSG--------C--------SSSHCW 188
            ....:||.:..::|.||....|.|:|:  .:.:.|: .||.|        |        :...||
  Rat   142 EKNQELCHLSTIDWGLLQPAPGANHIVGNKLGEECA-DVCPGVLGAAGEPCVRTTFGGHTDYRCW 205

  Fly   189 SNHYCQ------RSINENVANPKANINACHEECLGGCKNNSSSPADCSVCRGLSDDGVCVKSCPK 247
            ::.:||      |.:...|..     ..||.|||||| :....|..|..||.|...|||:.:||.
  Rat   206 TSSHCQRVCPCPRGLACTVGG-----ECCHSECLGGC-SQPEDPRACVACRHLYFQGVCLPTCPP 264

  Fly   248 DKYVMENYQRCYTKAEC-----VLKH--GYVISGSQCVAFCPSGYKTNNRSECVLCSPDEACISF 305
            ..|..|:: ||.|...|     |..|  .:.|....|:|.||.|:..|..|  :.|   ..|...
  Rat   265 GTYQYESW-RCVTAELCGHLREVPGHATAFGIYEGSCLAQCPPGFTRNGSS--IFC---HKCEGL 323

  Fly   306 CTPEWPGKAFTVYNLADAENLRGCQIFNGSLVITIRNKVN-ETQLYQSFTSMREVRGHVKVYRSS 369
            |..|......|:.::...::|.||....|||::.:|...| |.:|.::...:..:.|.:|:..|.
  Rat   324 CPKECKVGTKTIDSVQATQDLVGCTHVEGSLILNLRQGYNLEPELQRNLGLVETITGFLKIKHSF 388

  Fly   370 QLRSLQFLRNLERVHGDPLENRHYSFILYDNKELSEL--WTPSRQLEFMEGGMFMHRNNKLCNRR 432
            .|.:|.|.:||:.:.||.:.:.:|:..:.||:.|.:|  |. :..|....|.::...|.:||...
  Rat   389 ALVTLGFFKNLKLIRGDSMVDGNYTLYVLDNQNLQQLGSWV-AAGLTIPVGKIYFAFNPRLCLEH 452

  Fly   433 MREFQNAVTHDRALDSL-----QTNDQEVQCSPLKLQLYVQKRTHRSVKLSWLKSQTSQKIELIH 492
            :.:.:. ||..|...|.     :||.....|....|:..........:.|.|.:.:     .|..
  Rat   453 IYQLEE-VTGTRGRQSKAEINPRTNGDRAACQTRTLRFVFNLTEEDRILLRWERYE-----PLEA 511

  Fly   493 RPLLPGKLYHEESEL---------DAPICTRINWKRRLLFPDDLIENGTHYLFDLDDLQPDTRYV 548
            |.||...:|::||..         ||  |...:|  .||..:..:.........|..|:|.|:|.
  Rat   512 RDLLSFIVYYKESPFQNATEHVGPDA--CGTQSW--NLLDVELPLSRTQEPGVTLAPLKPWTQYA 572

  Fly   549 VLLR----TFGNDEAHEAYEARSELTYVQTELDIPKPPLL--ELVKKTDSS--LTVQ----MASH 601
            |.:|    |...|..|:.  |:|.:.|::|   :|..|.:  :::..::||  |.|:    :..:
  Rat   573 VFVRAITLTTAEDSPHQG--AQSPIVYLRT---LPAAPTVPQDVISTSNSSSHLLVRWKPPVQRN 632

  Fly   602 DHVSFLLTVFE-LSDDQD-YIEQRNYCHQ----PSYVWQ---DMDGPRWMAYEDYDDCC------ 651
            .::::.|.::: |::|.| ||  .:|||:    |:....   |.:.|...| |....||
  Rat   633 GNITYYLVLWQRLAEDGDLYI--NDYCHRGLRLPTSSHDTRFDREDPALEA-EPEQGCCPCQHSP 694

  Fly   652 ---------AQKA---EQFED--SRFIADMREQYRCT------LDDREQCRRLAHTEVSLPQLRL 696
                     ||:.   ::||:  ...|...:..::.|      ..|.|:.||    |..|  |||
  Rat   695 PGQALPALEAQEVTFQKKFENFLHHAITIPKAPWKVTSINKNPQRDSERHRR----ETGL--LRL 753

  Fly   697 PGNTTEYE------------LKALHRYRLYALQLQACN----PLGCSSHTTLYGRTNYTMGADLL 745
            ..|.:::|            |..|..:..|.:.:.|||    .:|||:.|.::.||.....||.:
  Rat   754 GKNNSDFEIHEDKVPRERAVLSGLRHFTEYRIDIHACNHAAHTVGCSAATFVFARTMPHREADGI 818

  Fly   746 TQLYACHIPEMDKYIMRFEEPKKPNGLVTNYVIHFRNNFSQTHVGCVTRMDHQSAGYMYVKQINI 810
            ..............|:.:.||..||||:..|.|.:|....:..|.||:|:.:...|.:::..:..
  Rat   819 PGKVVWKAVGKSSVILHWLEPPDPNGLILKYEIKYRRLGEEATVLCVSRLRYAKVGGVHLALLPP 883

  Fly   811 TFTECAVRVHSLAGD 825
            ......||..||||:
  Rat   884 GNYSAKVRATSLAGN 898

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10702	NP_001188841.1	Recep_L_domain	47..159	CDD:279382	42/111 (38%)
		Furin-like	171..297	CDD:279142	45/154 (29%)
		FU	210..258	CDD:238021	20/47 (43%)
		Recep_L_domain	328..441	CDD:279382	30/115 (26%)
Insrr	NP_071548.2	Recep_L_domain	47..158	CDD:279382	41/110 (37%)
		Furin-like	173..326	CDD:279142	48/165 (29%)
		FU	228..275	CDD:238021	21/48 (44%)
		Recep_L_domain	346..460	CDD:279382	30/115 (26%)
		FN3	494..600	CDD:238020	28/116 (24%)
		FN3	605..>649	CDD:238020	7/43 (16%)
		FN3	819..908	CDD:238020	21/80 (26%)
		PTKc_InsR_like	972..1248	CDD:173625
		Pkinase_Tyr	979..1246	CDD:285015
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1270..1300
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D120934at33208
OrthoFinder	1	1.000	-	-		FOG0001171
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.920