Protein Alignment CG10702 and InR

DIOPT Version :10

• Sequence 1: NP_724157.1
• Gene: CG10702 / 35181
• FlyBaseID: FBgn0032752
• Length: 946
• Species: Drosophila melanogaster
• Sequence 2: NP_524436.2
• Gene: InR / 42549
• FlyBaseID: FBgn0283499
• Length: 2144
• Species: Drosophila melanogaster
• Alignment Length: 1111
• Identity: 263/1111 - (23%)
• Similarity: 436/1111 - (39%)
• Gaps: 294/1111 - (26%)

  Fly    24 SKKEHECTSIDIRNECKNMHLLDNCTVVTGYVMITLITIEQRCNFSEYSYPLLTEITEFMIFTDV 88
            |:....|.|:||||...:.:.|:||||:.|:::|.||......|   .|:|.|||:|:::|...|
  Fly   333 SQNVKPCKSMDIRNMVSHFNQLENCTVIEGFLLIDLINDASPLN---RSFPKLTEVTDYIIIYRV 394

  Fly    89 RGLVNITEMFPHLTVIRGRRLFLNYALGVTNMHELEQLVFPKLVAIQRGQVYIGSCPKLCSIGRV 153
            .||.:::::||:|:||||.:||..|||.|.:..:|..|...||.:|.||.|.|....|||....:
  Fly   395 TGLHSLSKIFPNLSVIRGNKLFDGYALVVYSNFDLMDLGLHKLRSITRGGVRIEKNHKLCYDRTI 459

  Fly   154 NWDLLTLTRGENNIIMVNKN-----CSTPVCSG--------------------CSSSH----CWS 189
            :| |..|...|..::::.:|     |....|.|                    |...:    ||:
  Fly   460 DW-LEILAENETQLVVLTENGKEKECRLSKCPGEIRIEEGHDTTAIEGELNASCQLHNNRRLCWN 523

  Fly   190 NHYCQRSINENVANPKANIN-ACHEECLGGCKNNSSSPADCSVCRGLSDDGVCVKSCPKDKYVME 253
            :..||....|...|...:.: .|.::|||||..:.:....|..||.:|.:.:|:.||||..|..:
  Fly   524 SKLCQTKCPEKCRNNCIDEHTCCSQDCLGGCVIDKNGNESCISCRNVSFNNICMDSCPKGYYQFD 588

  Fly   254 NYQRCYTKAECV----LKHGYVISG----SQCVAFCPSGY-KTNNRSECVLCSPDEACISFCTPE 309
            :  ||.|..||:    .:...|.||    .||:..||:|| |:.|:..|..| |...|...|:
  Fly   589 S--RCVTANECITLTKFETNSVYSGIPYNGQCITHCPTGYQKSENKRMCEPC-PGGKCDKECS-- 648

  Fly   310 WPGKAFTVYNLADAENLRGCQIFNGSLVITIRNKVNE-----TQLYQSFTSMREVRGHVKVYRSS 369
                :..:.:|..|....||.|..|:..:||..|...     .:|.....::.:::..:.|:.:.
  Fly   649 ----SGLIDSLERAREFHGCTIITGTEPLTISIKRESGAHVMDELKYGLAAVHKIQSSLMVHLTY 709

  Fly   370 QLRSLQFLRNLERVHGD-PLENRHYSFILYDNKELSELWTPSRQLEFMEGGMFMHRNNKLCNRRM 433
            .|:||:|.::|..:.|| |::...|:..:.||::|.|||.|::.:...:||:|.|.|.|||...:
  Fly   710 GLKSLKFFQSLTEISGDPPMDADKYALYVLDNRDLDELWGPNQTVFIRKGGVFFHFNPKLCVSTI 774

  Fly   434 RE-----------FQNAVTHDRALDSLQTNDQEVQCSPLKLQLYVQKRTHRSVKLSWLKSQTSQK 487
            .:           |:.:   |...||   |.....|....|.:.:|.....|..|:     .:.|
  Fly   775 NQLLPMLASKPKFFEKS---DVGADS---NGNRGSCGTAVLNVTLQSVGANSAMLN-----VTTK 828

  Fly   488 IELIHRPLLPGK---------------LYH-------EESELDAPICTRINWKRRLLFPDDLIEN 530
            :| |..|..|..               .||       .....|.|...|  ||  :..|:   ::
  Fly   829 VE-IGEPQKPSNATIVFKDPRAFIGFVFYHMIDPYGNSTKSSDDPCDDR--WK--VSSPE---KS 885

  Fly   531 GTHYLFDLDDLQPDTRYVVLLRTFGNDEAHEAYEARSELTYVQTELDIPKPPLLELVKK--TDSS 593
            |   :..|.:|.|.|.|...:||..  .:.|...|.|::...:|....|. .:.|:|..  :||.
  Fly   886 G---VMVLSNLIPYTNYSYYVRTMA--ISSELTNAESDVKNFRTNPGRPS-KVTEVVATAISDSK 944

  Fly   594 LTVQMASHDHVSFLLTVF----ELSDDQDYIEQRNYCHQPSYVWQDMD----------------- 637
            :.|..:..|....:||.:    :|.:.......|:||.:|.....:.|
  Fly   945 INVTWSYLDKPYGVLTRYFIKAKLINRPTRNNNRDYCTEPLVKAMENDLPATTPTKKISDPLAGD 1009

  Fly   638 -----GPRWMAYEDYDDCCAQKAEQFEDSR----FIADMREQYRCTLDDREQCRRLA-------- 685
                 |.:..:.::|||...|...:||::.    |:.::|:....:.|..:.....|
  Fly  1010 CKCVEGSKKTSSQEYDDRKVQAGMEFENALQNFIFVPNIRKSKNGSSDKSDGAEGAALDSNAIPN 1074

  Fly   686 ---------HTEVSL-PQL---------------------------------------------- 694
                     ..:|:| |:|
  Fly  1075 GGATNPSRRRRDVALEPELDDVEGSVLLRHVRSITDDTDAFFEKDDENTYKDEEDLSSNKQFYEV 1139

  Fly   695 ---RLPGNTTEYELKALHRYRLYALQLQACN---PLG-----------CSSHTTLYGRTNYTMGA 742
               .||.|.|.:..:.|..:..||:.:.||.   |..           ||.:.|::..|.....|
  Fly  1140 FAKELPPNQTHFVFEKLRHFTRYAIFVVACREEIPSEKLRDTSFKKSLCSDYDTVFQTTKRKKFA 1204

  Fly   743 DLLTQLYAC--HIPEMDKYI-MRFEEPKKPNGLVTNYVIHFR----NNFSQTHVGCVTRMD-HQS 799
            |::..|...  |....:..: :|:..|..|||.:..|.:.::    :...:..  |:...| :|:
  Fly  1205 DIVMDLKVDLEHANNTESPVRVRWTPPVDPNGEIVTYEVAYKLQKPDQVEEKK--CIPAADFNQT 1267

  Fly   800 AGYMYVKQINITFTECAVRVHSLAGDVMTPYMPISLCSDEDRLQAFHSREAKDLSPEITDLPATA 864
            |||:.  ::|.......||.:|:||     |        .|..:..|.:        :...|:.|
  Fly  1268 AGYLI--KLNEGLYSFRVRANSIAG-----Y--------GDFTEVEHIK--------VEPPPSYA 1309

  Fly   865 S-----HGRGISIFLICFLFGCSVSLVWVLYKRRCWRKLP--------------GLRRYVPVREQ 910
            .     .|.|:: |||..|||      :|.|..:  ||:|              ...:|:|  :.
  Fly  1310 KVFFWLLGIGLA-FLIVSLFG------YVCYLHK--RKVPSNDLHMNTEVNPFYASMQYIP--DD 1363

  Fly   911 W--LRD 914
            |  ||:
  Fly  1364 WEVLRE 1369

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG10702	NP_724157.1	Recep_L_domain	47..159	CDD:460032	46/111 (41%)
		Furin-like	171..297	CDD:395614	44/164 (27%)
		Recep_L_domain	328..441	CDD:460032	34/129 (26%)
InR	NP_524436.2	Recep_L_domain	356..465	CDD:460032	46/112 (41%)
		Furin-like	510..645	CDD:395614	43/137 (31%)
		Recep_L_domain	663..781	CDD:460032	33/117 (28%)
		FN3	791..>964	CDD:442628	43/197 (22%)
		FN3	1224..1302	CDD:238020	21/102 (21%)
		PTKc_InsR_like	1364..1652	CDD:173625	3/6 (50%)