DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10702 and Egfr

DIOPT Version :9

Sequence 1:	NP_001188841.1	Gene:	CG10702 / 35181	FlyBaseID:	FBgn0032752	Length:	946	Species:	Drosophila melanogaster
Sequence 2:	NP_476759.1	Gene:	Egfr / 37455	FlyBaseID:	FBgn0003731	Length:	1426	Species:	Drosophila melanogaster

Alignment Length:	488	Identity:	122/488 - (25%)
Similarity:	188/488 - (38%)	Gaps:	134/488 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 LYVPCAESKKEH----------ECTSID-------IRNECKNMHLLDNCTVVTGYVMITLITIEQ 64
            |.||   |.|||          .||.:|       :.||..::..|||...||||::|:.:
  Fly   109 LSVP---SNKEHHYRNLRDRYTNCTYVDGNLELTWLPNENLDLSFLDNIREVTGYILISHV---- 166

  Fly    65 RCNFSEYSYPLLTEITEFMIFTDVRGLVNITEMFPHLTVIRGRRLFL------NYALGVT--NMH 121
                                  ||:.:|     ||.|.:||||.||.      .|||.||  .|:
  Fly   167 ----------------------DVKKVV-----FPKLQIIRGRTLFSLSVEEEKYALFVTYSKMY 204

  Fly   122 ELEQLVFPKLVAIQRGQVYIGSCPKLCSIGRVNWDLLTLTRGEN-----NIIMVNKNCSTPVCSG 181
            .||   .|.|..:..|||...:...||.:..:.|..: ::.|.:     :.....:.|  |.|..
  Fly   205 TLE---IPDLRDVLNGQVGFHNNYNLCHMRTIQWSEI-VSNGTDAYYNYDFTAPEREC--PKCHE 263

  Fly   182 CSSSHCWSN--HYCQR----SINENVA-----NPKANINACHEECLGGCKNNSSSPADCSVCRGL 235
            ..:..||..  ..||:    :.:...|     .||.. ..||..|.|||  ...:..||..|:..
  Fly   264 SCTHGCWGEGPKNCQKFSKLTCSPQCAGGRCYGPKPR-ECCHLFCAGGC--TGPTQKDCIACKNF 325

  Fly   236 SDDGVCVKSCPKDK------YVMENYQRCYTKAECVLKHGYVISGSQCVAFCPSGYKTNNRSECV 294
            .|:|||.:.||..:      ||:|      |..|.  |:.|   |:.||..|| |:...:...||
  Fly   326 FDEGVCKEECPPMRKYNPTTYVLE------TNPEG--KYAY---GATCVKECP-GHLLRDNGACV 378

  Fly   295 LCSPDE---------ACISFCTPEWPGKAFTVYNLADAENLRGCQIFNGSLVITIRNKVNETQLY 350
            ...|.:         .|...|....||  .||.:..:.::.|.|.:.:|::.|..:.......:|
  Fly   379 RSCPQDKMDKGGECVPCNGPCPKTCPG--VTVLHAGNIDSFRNCTVIDGNIRILDQTFSGFQDVY 441

  Fly   351 QSFT-----------------SMREVRGHVKVYRS-SQLRSLQFLRNLERVHGDPLENRHYSFIL 397
            .::|                 :::|:.|::.:..: .|.|:|.:.||||.:||..|....::.:.
  Fly   442 ANYTMGPRYIPLDPERLEVFSTVKEITGYLNIEGTHPQFRNLSYFRNLETIHGRQLMESMFAALA 506

  Fly   398 YDNKELSELWTPSRQL-EFMEGGMFMHRNNKLC 429
            .....|..|  ..|.| :...|.:.:..|..||
  Fly   507 IVKSSLYSL--EMRNLKQISSGSVVIQHNRDLC 537

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10702	NP_001188841.1	Recep_L_domain	47..159	CDD:279382	34/119 (29%)
		Furin-like	171..297	CDD:279142	40/142 (28%)
		FU	210..258	CDD:238021	18/53 (34%)
		Recep_L_domain	328..441	CDD:279382	25/121 (21%)
Egfr	NP_476759.1	Recep_L_domain	419..547	CDD:279382	25/121 (21%)
		GF_recep_IV	572..684	CDD:291509
		FU	573..>606	CDD:238021
		FU	617..659	CDD:214589
		FU	662..716	CDD:214589
		FU	739..786	CDD:238021
		FU	784..834	CDD:214589
		PTKc_EGFR_like	930..1208	CDD:270648
		STYKc	938..1194	CDD:214568
		Recep_L_domain	128..239	CDD:279382	41/145 (28%)
		Furin-like	253..401	CDD:279142	43/164 (26%)
		FU	255..292	CDD:214589	8/38 (21%)
		FU	302..345	CDD:238021	15/44 (34%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24416
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	2.010