DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment CG10702 and INSRR

DIOPT Version :9

Sequence 1:NP_001188841.1 Gene:CG10702 / 35181 FlyBaseID:FBgn0032752 Length:946 Species:Drosophila melanogaster
Sequence 2:NP_055030.1 Gene:INSRR / 3645 HGNCID:6093 Length:1297 Species:Homo sapiens


Alignment Length:1003 Identity:263/1003 - (26%)
Similarity:436/1003 - (43%) Gaps:169/1003 - (16%)


- Green bases have known domain annotations that are detailed below.


  Fly    30 CTSIDIRNECKNMHLLDNCTVVTGYVMITLITIEQRCNFSEYSYPLLTEITEFMIFTDVRGLVNI 94
            |.|:|||:|...:..|:||:||.|::.|.|:......:|...|:|.||::|::::...|.||.::
Human    30 CPSLDIRSEVAELRQLENCSVVEGHLQILLMFTATGEDFRGLSFPRLTQVTDYLLLFRVYGLESL 94

  Fly    95 TEMFPHLTVIRGRRLFLNYALGVTNMHELEQLVFPKLVAIQRGQVYIGSCPKLCSIGRVNWDLLT 159
            .::||:|.||||.||||.|||.:..|..|..:..|.|.|:.||.|.:....:||.:..::|.||.
Human    95 RDLFPNLAVIRGTRLFLGYALVIFEMPHLRDVALPALGAVLRGAVRVEKNQELCHLSTIDWGLLQ 159

  Fly   160 LTRGENNII--MVNKNCSTPVCSG--------CS----SSH----CWSNHYCQRSINENVANP-- 204
            ...|.|:|:  .:.:.|: .||.|        |:    |.|    ||::.:|||      ..|  
Human   160 PAPGANHIVGNKLGEECA-DVCPGVLGAAGEPCAKTTFSGHTDYRCWTSSHCQR------VCPCP 217

  Fly   205 -----KANINACHEECLGGCKNNSSSPADCSVCRGLSDDGVCVKSCPKDKYVMENYQRCYTKAEC 264
                 .|....||.|||||| :....|..|..||.|...|.|:.:||...|..|:: ||.|...|
Human   218 HGMACTARGECCHTECLGGC-SQPEDPRACVACRHLYFQGACLWACPPGTYQYESW-RCVTAERC 280

  Fly   265 VLKHG-------YVISGSQCVAFCPSGYKTNNRSECVLCSPDEACISFCTPEWPGKAFTVYNLAD 322
            ...|.       :.|....|:|.||||:..|:.|  :.|   ..|...|..|......|:.::..
Human   281 ASLHSVPGRASTFGIHQGSCLAQCPSGFTRNSSS--IFC---HKCEGLCPKECKVGTKTIDSIQA 340

  Fly   323 AENLRGCQIFNGSLVITIRNKVN-ETQLYQSFTSMREVRGHVKVYRSSQLRSLQFLRNLERVHGD 386
            |::|.||....|||::.:|...| |.||..|...:..:.|.:|:..|..|.||.|.:||:.:.||
Human   341 AQDLVGCTHVEGSLILNLRQGYNLEPQLQHSLGLVETITGFLKIKHSFALVSLGFFKNLKLIRGD 405

  Fly   387 PLENRHYSFILYDNKELSEL--WTPSRQLEFMEGGMFMHRNNKLCNRRMREFQNAV----THDRA 445
            .:.:.:|:..:.||:.|.:|  |. :..|....|.::...|.:||...:...:...    ..::|
Human   406 AMVDGNYTLYVLDNQNLQQLGSWV-AAGLTIPVGKIYFAFNPRLCLEHIYRLEEVTGTRGRQNKA 469

  Fly   446 LDSLQTNDQEVQCSPLKLQLYVQKRTHRSVKLSWLKSQTSQKIELIHRPLLPGKLYHEESEL--- 507
            ..:.:||.....|....|:..........:.|.|.:.:     .|..|.||...:|::||..   
Human   470 EINPRTNGDRAACQTRTLRFVSNVTEADRILLRWERYE-----PLEARDLLSFIVYYKESPFQNA 529

  Fly   508 ------DAPICTRINWKRRLLFPDDLIENGTHYLFDLDDLQPDTRYVVLLR----TFGNDEAHEA 562
                  ||  |...:|  .||..:..:.........|..|:|.|:|.|.:|    |...|..|:.
Human   530 TEHVGPDA--CGTQSW--NLLDVELPLSRTQEPGVTLASLKPWTQYAVFVRAITLTTEEDSPHQG 590

  Fly   563 YEARSELTYVQTELDIPKPPLL--ELVKKTDSS--LTVQ----MASHDHVSFLLTVFE-LSDDQD 618
              |:|.:.|::|   :|..|.:  :::..::||  |.|:    ...:.::::.|.::: |::|.|
Human   591 --AQSPIVYLRT---LPAAPTVPQDVISTSNSSSHLLVRWKPPTQRNGNLTYYLVLWQRLAEDGD 650

  Fly   619 -YIEQRNYCHQPSYVWQDMDGPRWMAYEDYD-------DCC---------------AQKA---EQ 657
             |:  .:|||:...:....:.||:.. ||.|       |||               ||:|   ::
Human   651 LYL--NDYCHRGLRLPTSNNDPRFDG-EDGDPEAEMESDCCPCQHPPPGQVLPPLEAQEASFQKK 712

  Fly   658 FED--SRFIADMREQYRCTLDDREQCRRLAHTEVSLPQLRLPGNTTEYE------------LKAL 708
            ||:  ...|......::.|..::...|.......:...|||.||::::|            |..|
Human   713 FENFLHNAITIPISPWKVTSINKSPQRDSGRHRRAAGPLRLGGNSSDFEIQEDKVPRERAVLSGL 777

  Fly   709 HRYRLYALQLQACN----PLGCSSHTTLYGRTNYTMGADLLTQLYACHIPEMDKYIMRFEEPKKP 769
            ..:..|.:.:.|||    .:|||:.|.::.||.....||.:....|......:..::|:.||..|
Human   778 RHFTEYRIDIHACNHAAHTVGCSAATFVFARTMPHREADGIPGKVAWEASSKNSVLLRWLEPPDP 842

  Fly   770 NGLVTNYVIHFRNNFSQTHVGCVTRMDHQSAGYMYVKQINITFTECAVRVHSLAGD-VMTPYMPI 833
            |||:..|.|.:|....:..|.||:|:.:...|.:::..:........||..||||: ..|..:..
Human   843 NGLILKYEIKYRRLGEEATVLCVSRLRYAKFGGVHLALLPPGNYSARVRATSLAGNGSWTDSVAF 907

  Fly   834 SLCSDEDRLQAFHSREAKDLSPEITDLPATASHGRGISIFLICFLFGCSVSLVWVLYKRRCWRKL 898
            .:...|:       .:|..|...:|..|.      |:::.::....|       ..|.::..|.|
Human   908 YILGPEE-------EDAGGLHVLLTATPV------GLTLLIVLAALG-------FFYGKKRNRTL 952

  Fly   899 ---------PGLRRYVPVREQWLRDRQQ 917
                     .....|||  ::|...|:|
Human   953 YASVNPEYFSASDMYVP--DEWEVPREQ 978

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG10702NP_001188841.1 Recep_L_domain 47..159 CDD:279382 42/111 (38%)
Furin-like 171..297 CDD:279142 47/155 (30%)
FU 210..258 CDD:238021 19/47 (40%)
Recep_L_domain 328..441 CDD:279382 33/119 (28%)
INSRRNP_055030.1 Recep_L_domain 47..158 CDD:279382 41/110 (37%)
Furin-like 173..326 CDD:279142 50/166 (30%)
FU 228..275 CDD:238021 20/48 (42%)
Recep_L_domain 346..460 CDD:279382 33/114 (29%)
FN3 490..600 CDD:238020 28/120 (23%)
FN3 605..>649 CDD:238020 7/43 (16%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 666..687 5/21 (24%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 732..758 6/25 (24%)
FN3 819..908 CDD:238020 23/88 (26%)
PTKc_InsR_like 972..1248 CDD:173625 3/7 (43%)
Pkinase_Tyr 979..1246 CDD:285015 263/1003 (26%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1267..1297
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG4258
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D120934at33208
OrthoFinder 1 1.000 - - FOG0001171
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
43.820

Return to query results.
Submit another query.