DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10702 and INSR

DIOPT Version :9

Sequence 1:	NP_001188841.1	Gene:	CG10702 / 35181	FlyBaseID:	FBgn0032752	Length:	946	Species:	Drosophila melanogaster
Sequence 2:	NP_000199.2	Gene:	INSR / 3643	HGNCID:	6091	Length:	1382	Species:	Homo sapiens

Alignment Length:	1018	Identity:	267/1018 - (26%)
Similarity:	434/1018 - (42%)	Gaps:	224/1018 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 CTSIDIRNECKNMHLLDNCTVVTGYVMITLITIEQRCNFSEYSYPLLTEITEFMIFTDVRGLVNI 94
            |..:||||....:|.|:||:|:.|::.|.|:...:..:|.:.|:|.|..||::::...|.||.::
Human    35 CPGMDIRNNLTRLHELENCSVIEGHLQILLMFKTRPEDFRDLSFPKLIMITDYLLLFRVYGLESL 99

  Fly    95 TEMFPHLTVIRGRRLFLNYALGVTNMHELEQLVFPKLVAIQRGQVYIGSCPKLCSIGRVNWDLLT 159
            .::||:||||||.|||.||||.:..|..|::|....|:.|.||.|.|....:||.:..::|..:
Human   100 KDLFPNLTVIRGSRLFFNYALVIFEMVHLKELGLYNLMNITRGSVRIEKNNELCYLATIDWSRI- 163

  Fly   160 LTRGENNIIMVNK------------------NCSTPVCSGCSSSHCWSNHYCQRSINENVANP-- 204
            |...|:|.|::||                  ||...|.:|.....||::.:||: :...:...
Human   164 LDSVEDNYIVLNKDDNEECGDICPGTAKGKTNCPATVINGQFVERCWTHSHCQK-VCPTICKSHG 227

  Fly   205 -KANINACHEECLGGCKNNSSSPADCSVCRGLSDDGVCVKSCPKDKYVMENYQRCYTKAEC---- 264
             .|....||.||||.| :....|..|..||....||.||::||...|..::: ||...:.|
Human   228 CTAEGLCCHSECLGNC-SQPDDPTKCVACRNFYLDGRCVETCPPPYYHFQDW-RCVNFSFCQDLH 290

  Fly   265 -VLK-------HGYVISGSQCVAFCPSGYKTNNRSECVLCSPDEACISFCTPE----WPGKAFTV 317
             ..|       |.|||..::|:..|||||..|  |..:||:|   |:..| |:    ..|:. |:
Human   291 HKCKNSRRQGCHQYVIHNNKCIPECPSGYTMN--SSNLLCTP---CLGPC-PKVCHLLEGEK-TI 348

  Fly   318 YNLADAENLRGCQIFNGSLVITIRNKVN-ETQLYQSFTSMREVRGHVKVYRSSQLRSLQFLRNLE 381
            .::..|:.||||.:.||||:|.||...| ..:|..:...:.|:.|::|:.||..|.||.|.|.|.
Human   349 DSVTSAQELRGCTVINGSLIINIRGGNNLAAELEANLGLIEEISGYLKIRRSYALVSLSFFRKLR 413

  Fly   382 RVHGDPLENRHYSFILYDNKELSELWTPSR-QLEFMEGGMFMHRNNKLC---NRRMREFQNAVTH 442
            .:.|:.||..:|||...||:.|.:||..|: .|...:|.:|.|.|.|||   ..:|.|.......
Human   414 LIRGETLEIGNYSFYALDNQNLRQLWDWSKHNLTITQGKLFFHYNPKLCLSEIHKMEEVSGTKGR 478

  Fly   443 DRALD-SLQTNDQEVQCSPLKLQLYVQKRTHRSVKLSWLKSQTSQKIELIHRP--------LLPG 498
            ....| :|:||..:..|.            :..:|.|:::: :..||.|...|        ||..
Human   479 QERNDIALKTNGDQASCE------------NELLKFSYIRT-SFDKILLRWEPYWPPDFRDLLGF 530

  Fly   499 KLYHEE------SELDA-PICTRINWKRRLLFP-----DDLIENGTHYLFDLDDLQPDTRYVVLL 551
            .|:::|      :|.|. ..|...:|....:.|     |...:|...:|  :..|:|.|:|.:.:
Human   531 MLFYKEAPYQNVTEFDGQDACGSNSWTVVDIDPPLRSNDPKSQNHPGWL--MRGLKPWTQYAIFV 593

  Fly   552 RTF--GNDEAHEAYEARSELTYVQTELDIPKPPLLEL-VKKTDSSLTVQMA----SHDHVSFLLT 609
            :|.  .:|| ...|.|:|::.||||:...|..||..: |..:.|.:.::..    .:.:::..|.
Human   594 KTLVTFSDE-RRTYGAKSDIIYVQTDATNPSVPLDPISVSNSSSQIILKWKPPSDPNGNITHYLV 657

  Fly   610 VFELSDDQDYIEQRNYCHQ----PSYVW------QDMDGPRWMAYED-YDDCCAQKAEQFEDSRF 663
            .:|...:...:.:.:||.:    ||..|      :|........||| ..:||:...   .||:.
Human   658 FWERQAEDSELFELDYCLKGLKLPSRTWSPPFESEDSQKHNQSEYEDSAGECCSCPK---TDSQI 719

  Fly   664 IADMRE-QYRCTLDD--------------------------REQCRRLAHTEVSLPQLRLPGNTT 701
            :.::.| .:|.|.:|                          |.....:.:..|::|.:....||:
Human   720 LKELEESSFRKTFEDYLHNVVFVPRKTSSGTGAEDPRPSRKRRSLGDVGNVTVAVPTVAAFPNTS 784

  Fly   702 E------------YE---------LKALHRYRLYALQLQACN----PLGCSSHTTLYGRTNYTMG 741
            .            :|         :..|..:..|.::|||||    ...||....:..||.....
Human   785 STSVPTSPEEHRPFEKVVNKESLVISGLRHFTGYRIELQACNQDTPEERCSVAAYVSARTMPEAK 849

  Fly   742 ADLLTQLYACHIPEMDKYIMRFEEPKKPNGLVTNYVIHFRNN--------FSQTHV----GCVTR 794
            ||.:.......|.|.:...:.::|||:||||:..|.:.:|..        .|:.|.    ||  |
Human   850 ADDIVGPVTHEIFENNVVHLMWQEPKEPNGLIVLYEVSYRRYGDEELHLCVSRKHFALERGC--R 912

  Fly   795 MDHQSAGYMYVKQINITFTECAVRVHSLAGD---------VMTPYMPISLCSDEDRLQAFHSREA 850
            :...|.|...|:          :|..||||:         .:|.|:.:.            |..|
Human   913 LRGLSPGNYSVR----------IRATSLAGNGSWTEPTYFYVTDYLDVP------------SNIA 955

  Fly   851 KDLSPEITDLPATASHGRGISIFLICFLFGCSVSLVWVLYKRR 893
            |.:                |...:..|||...:..:::..::|
Human   956 KII----------------IGPLIFVFLFSVVIGSIYLFLRKR 982

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10702	NP_001188841.1	Recep_L_domain	47..159	CDD:279382	42/111 (38%)
		Furin-like	171..297	CDD:279142	46/158 (29%)
		FU	210..258	CDD:238021	18/47 (38%)
		Recep_L_domain	328..441	CDD:279382	44/117 (38%)
INSR	NP_000199.2	Recep_L_domain	52..164	CDD:279382	42/112 (38%)
		Furin-like	179..337	CDD:279142	48/166 (29%)
		FU	234..281	CDD:238021	19/48 (40%)
		Recep_L_domain	359..472	CDD:279382	43/112 (38%)
		FN3	622..>665	CDD:238020	7/42 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	686..708		4/21 (19%)
		Insulin-binding	733..741		1/7 (14%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	746..766		1/19 (5%)
		FN3	867..944	CDD:238020	22/88 (25%)
		PTKc_InsR	1016..1303	CDD:133192
		Pkinase_Tyr	1023..1290	CDD:285015
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1360..1382
		PIK3R1-binding	1361..1364
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG4258
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D120934at33208
OrthoFinder	1	1.000	-	-		FOG0001171
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.820