DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10702 and Ros1

DIOPT Version :9

Sequence 1:	NP_001188841.1	Gene:	CG10702 / 35181	FlyBaseID:	FBgn0032752	Length:	946	Species:	Drosophila melanogaster
Sequence 2:	XP_038954373.1	Gene:	Ros1 / 25346	RGDID:	3591	Length:	2339	Species:	Rattus norvegicus

Alignment Length:	860	Identity:	156/860 - (18%)
Similarity:	283/860 - (32%)	Gaps:	306/860 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   132 VAIQRGQVYIGSCPKLC--SIGRVNWDLLTLTRGENNIIMVNKNCSTPVCSGCSSSHCWSNHYCQ 194
            :::.:|.: :.||...|  ::||      .|..|      ...|.|.....||   ..|:
  Rat    22 ISVAQGTI-LSSCLTSCVTNLGR------QLDSG------TRYNLSEACIQGC---QFWN----- 65

  Fly   195 RSINENVANPKAN---INAC-HEECLGGCKN-----------NSSSPADCSVCRGLSDDGVCVKS 244
             ||::.....|.|   :..| .|.|..||.|           |:..|. ......:..:||.::.
  Rat    66 -SIDQEKCALKCNDTYVTICERESCEVGCSNAEGSYEEEVLDNTELPT-APFASSIGSNGVTLRW 128

  Fly   245 CPKD----KYVME-NYQR-----CYTKAECVLKHGYVIS----------------GSQCVAFCP- 282
            .|.:    ||::: .|.:     .||  |.|.|..|::.                .:|...:.|
  Rat   129 NPANISGVKYIIQWKYAQLPGSWAYT--ETVSKLSYMVEPLHPFTEYIFRVVWIFTAQLHLYSPP 191

  Fly   283 --------------SGYKTNNRSECVLCSPDEACISFCTPEWPGKAFTVYNLADAENLRGCQIFN 333
                          :.:.||..|.    |||...:|:..|.:||.....|||
  Rat   192 SPSYRTHPYGVPETAPFITNIESS----SPDTVEVSWAPPYFPGGPILGYNL------------- 239

  Fly   334 GSLVITIRNKVNETQLYQSFTSMREVRGHVKVYRSSQLRSLQFLRNLERVHGDPLENRHYSFILY 398
                    ..:::||               |:...:|..|.||.        ..|.|..|.|.:.
  Rat   240 --------RLISKTQ---------------KLDSGTQRTSFQFY--------STLPNTTYRFSIA 273

  Fly   399 DNKELSE-------LWTPSRQLEFMEGGMFMHRNNKLCNRRMRE--------FQNAVTHDRALDS 448
            ...|:.|       :.|||..::..|..:|:.|...|..|.::.        :.:|:.|:....|
  Rat   274 AVNEVGEGPEAESMITTPSPAVQEEEQWLFLSRKTSLRKRSLKYLVDEAHCLWSDAIRHNITGIS 338

  Fly   449 LQTNDQEVQCSPLKLQLYVQKRTHRSVKLSWLK--SQTSQKIELIHRPLLPGKLYHEESELDAPI 511
            :.| .|||        :|..:.|     :.|:|  :..|...:|        ::::..|.|.:.|
  Rat   339 VNT-QQEV--------VYFSEGT-----IIWMKGAANMSDVSDL--------RIFYRGSALVSSI 381

  Fly   512 CTRINW-KRRLLFPDDLIENGTH-----YLFDLDDLQP--------------------------- 543
              .::| .:|:.|   :::|..|     :..:|:::.|
  Rat   382 --SVDWLYQRMYF---IMDNRVHVCDLKHCSNLEEITPFSIVAPQKVVVDSYNGYVFYLLRDGIY 441

  Fly   544 ----------DTRYVVLLRTFG--NDEAHEAYEAR------SELTYVQTELD-------IPKPPL 583
                      ||:.|.::.: |  .|.|.:....|      :...::.|.||       :|..||
  Rat   442 RVHLPLPSVRDTKAVRIVES-GTLKDFAVKPQSKRIIYFNGTMQVFMSTFLDGSAFHRVLPWVPL 505

  Fly   584 LEL----VKKTDSSLTVQMASHDHVSFLLTVFELSDDQDYIEQRNYCH---------------QP 629
            .::    .:..|..:|...|.....|.....|.:..|..:||:..:.:               .|
  Rat   506 ADVKSFACENNDFLITDGKAIFQQDSLSFNEFIVGCDLSHIEEFGFGNLVIFGSSVQSYPLPGHP 570

  Fly   630 SYVWQDMDGPRWMAYEDYDDCCAQKAEQFEDSRFIADMREQYRCTLDDREQCRRLAHTEVSLPQL 694
            ..| ..:.|.|....:......|..|.......:..:::...:..|:..:....::.|.:::|:|
  Rat   571 QEV-SVLFGSREALIQWKPPILAIGASPSAWQNWTYEVKVSSQDILETTQVFLNISRTVLNVPKL 634

  Fly   695 RLPGNTTEYELKALHRYRLYALQLQACNPLG------CSSHTTLYGRTNYTMGADLLTQLYACHI 753
            :   ::|:           |.:.::|.:|.|      .|..|||...|.
  Rat   635 Q---SSTK-----------YMVSVRASSPKGPGPWSEPSVGTTLVPATE---------------- 669

  Fly   754 PEMDKYIMRFEEPKKPNGLVTNYVIHF-RNNFSQTHVGCVTRMD--------HQSAGYMYVKQIN 809
               ..:||..:|    :||.:..:..| ...|..:.||.|:.||        ..:.|.:||:.:|
  Rat   670 ---PPFIMAVKE----DGLWSKPLSSFGPGEFLSSDVGNVSDMDWYNNSLYYSDTKGNVYVRPLN 727

  Fly   810 ITFTECAVRVHSLAG 824
            .........:.|:||
  Rat   728 GMDISENYHISSIAG 742

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10702	NP_001188841.1	Recep_L_domain	47..159	CDD:279382	6/28 (21%)
		Furin-like	171..297	CDD:279142	34/181 (19%)
		FU	210..258	CDD:238021	14/69 (20%)
		Recep_L_domain	328..441	CDD:279382	22/127 (17%)
Ros1	XP_038954373.1	FN3	111..178	CDD:214495	13/69 (19%)
		FN3	211..290	CDD:238020	25/126 (20%)
		FN3	567..663	CDD:238020	16/110 (15%)
		FN3	1036..1142	CDD:238020
		FN3	1449..1527	CDD:214495
		FN3	1551..1630	CDD:238020
		FN3	1650..1741	CDD:238020
		FN3	1746..1839	CDD:238020
		PTKc_c-ros	1948..2209	CDD:270640
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910