DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10702 and Insrr

DIOPT Version :9

Sequence 1:	NP_001188841.1	Gene:	CG10702 / 35181	FlyBaseID:	FBgn0032752	Length:	946	Species:	Drosophila melanogaster
Sequence 2:	XP_006501514.1	Gene:	Insrr / 23920	MGIID:	1346037	Length:	1313	Species:	Mus musculus

Alignment Length:	1037	Identity:	269/1037 - (25%)
Similarity:	439/1037 - (42%)	Gaps:	205/1037 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 LGVGLMFLALYVPCAESKKEHECTSIDIRNECKNMHLLDNCTVVTGYVMITLITIEQRCNFSEYS 72
            ||.||..|.:            |.|:|||:|...:..|:||:||.|::.|.|:......:|...|
Mouse    20 LGSGLDTLEV------------CPSLDIRSEVTELRRLENCSVVEGHLQILLMFAATGEDFRGLS 72

  Fly    73 YPLLTEITEFMIFTDVRGLVNITEMFPHLTVIRGRRLFLNYALGVTNMHELEQLVFPKLVAIQRG 137
            :|.||::|::::...|.||.::.::||:||||||.||||.|||.:..|..|..:..|.|.|:.||
Mouse    73 FPRLTQVTDYLLLFRVYGLESLRDLFPNLTVIRGTRLFLGYALIIFEMPHLRDVGLPSLGAVLRG 137

  Fly   138 QVYIGSCPKLCSIGRVNWDLLTLTRGENNII-----------------MVNKNCSTPVCSGCSSS 185
            .|.:....:||.:..::|.||....|.|:|:                 ...:.||....||.:..
Mouse   138 AVRVEKNQELCHLSTIDWGLLQPAPGTNHIVGNKLGEECADVCPGVLGAAGEPCSRTTFSGRTDY 202

  Fly   186 HCWSNHYCQRSINENVANPK-----ANINACHEECLGGCKNNSSSPADCSVCRGLSDDGVCVKSC 245
            .||::.:||:.    ...|:     |..:.||.|||||| :....|..|..||.|...|||:::|
Mouse   203 RCWTSSHCQKV----CPCPRGMACTAGGDCCHSECLGGC-SQPEDPRACVACRHLYFQGVCLRAC 262

  Fly   246 PKDKYVMENYQRCYTKAECV-------LKHGYVISGSQCVAFCPSGYKTNNRSECVLCSPDEACI 303
            |...|..|:: ||.|...|.       |...:.|....|:|.||.|:..|..|  :.|   ..|.
Mouse   263 PPGTYQYESW-RCVTAELCAHLREVPGLATTFGIYEGSCLAQCPPGFTRNGSS--IFC---HKCE 321

  Fly   304 SFCTPEWPGKAFTVYNLADAENLRGCQIFNGSLVITIRNKVN-ETQLYQSFTSMREVRGHVKVYR 367
            ..|..|......|:.::...::|.||....|:|::.:|...| |.:|.::...:..:.|.:|:..
Mouse   322 GLCPKECKVGTKTIDSVQATQDLVGCTHVEGNLILNLRQGYNLEPELQRNLGLVETITGFLKIKH 386

  Fly   368 SSQLRSLQFLRNLERVHGDPLENRHYSFILYDNKELSEL--WTPSRQLEFMEGGMFMHRNNKLCN 430
            |..|.:|.|.:||:.:.||.:.:.:|:..:.||:.|.:|  |. :..|....|.::...|.:||.
Mouse   387 SFALVTLGFFKNLKLIRGDSMVDGNYTLYVLDNQNLQQLGSWV-TAGLTIPVGKIYFAFNPRLCL 450

  Fly   431 RRMREFQNAVTHDRALDSL-----QTNDQEVQCSPLKLQLYVQKRTHRSVKLSWLKSQTSQKIEL 490
            ..:.:.:. ||..|...|.     :||.....|....|:..........:.|.|.:.:     .|
Mouse   451 EHIYQLEE-VTGTRGRQSKAEINPRTNGDRAACQTRTLRFVFNLTEEDRILLRWERYE-----PL 509

  Fly   491 IHRPLLPGKLYHEESEL---------DAPICTRINWKRRLLFPDDLIENGTHYLFDLDDLQPDTR 546
            ..|.||...:|::||..         ||  |...:|  .||..:..:.........|..|:|.|:
Mouse   510 EARDLLSFIVYYKESPFQNATEHVGPDA--CGTQSW--NLLDVELPLSRTQEPGVTLAPLKPWTQ 570

  Fly   547 YVVLLR----TFGNDEAHEAYEARSELTYVQTELDIPKPPLL--ELVKKTDSS--LTVQ----MA 599
            |.|.:|    |...|..|:.  |:|.:.|::|   :|..|.:  :::..::||  |.|:    :.
Mouse   571 YAVFVRAITLTTAEDSPHQG--AQSPIVYLRT---LPAAPTVPQDVISTSNSSSHLLVRWKPPVQ 630

  Fly   600 SHDHVSFLLTVFE-LSDDQD-YIEQRNYCHQ----PSYVWQ---DMDGPRWMAYEDYDDCC---- 651
            .:.::::.|.::: |::|.| ||  .:|||:    |:....   |.:.|...| |....||
Mouse   631 RNGNITYYLVLWQRLAEDGDLYI--NDYCHRGLRLPTSSHDTRFDREDPALEA-EPEQGCCPCQH 692

  Fly   652 -----------AQKA---EQFED--SRFIADMREQYRCT------LDDREQCRRLAHTEVSLPQL 694
                       ||:.   ::||:  ...|...:..::.|      ..|.|:.||    |..|  |
Mouse   693 SPPGQALPALEAQEVTFQKKFENFLHHAITIPKAPWKVTSINKNPQRDSERHRR----EAGL--L 751

  Fly   695 RLPGNTTEYE------------LKALHRYRLYALQLQACN----PLGCSSHTTLYGRTNYTMGAD 743
            ||..|.:::|            |..|..:..|.:.:.|||    .:|||:.|.::.||.....||
Mouse   752 RLGKNNSDFEIQEDKVPRERAILSGLRHFTEYRIDIHACNHAAHTVGCSAATFVFARTMPHREAD 816

  Fly   744 LLTQLYACHIPEMDKYIMRFEEPKKPNGLVTNYVIHFRNNFSQTHVGCVTRMDHQSAGYMYVKQI 808
            .:....|..........:.:.||..||||:..|.|.:|....:..|.||:|:.:...|.:::..:
Mouse   817 GIPGKVAWKAAGKSSVTLHWLEPPDPNGLILKYEIKYRRLGEEATVLCVSRLRYAKVGGVHLALL 881

  Fly   809 NITFTECAVRVHSLAG-----DVMTPYMPISLCSDEDRLQAFHSREAKDLSPEITDLPATASHGR 868
            ........||..||||     |.:|.|:                   .||..|.|.
Mouse   882 PPGNYSAKVRATSLAGNGSWTDGVTFYI-------------------TDLEEEDTG--------- 918

  Fly   869 GISIFL----ICFLFGCSVSLVWVLYKRRCWRKL---------PGLRRYVPVREQWLRDRQQ 917
            |:.|||    :.|:...:::.:...|.|:....|         .....|||  ::|...|:|
Mouse   919 GMRIFLTVTPVGFMLLVTLAALGFFYSRKRNSTLYTSVNPEYFSASHMYVP--DEWEVPREQ 978

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10702	NP_001188841.1	Recep_L_domain	47..159	CDD:279382	43/111 (39%)
		Furin-like	171..297	CDD:279142	43/137 (31%)
		FU	210..258	CDD:238021	20/47 (43%)
		Recep_L_domain	328..441	CDD:279382	29/115 (25%)
Insrr	XP_006501514.1	Recep_L_domain	47..157	CDD:366426	42/109 (39%)
		Furin-like	173..329	CDD:366287	47/166 (28%)
		Recep_L_domain	346..459	CDD:366426	29/114 (25%)
		FN3	494..600	CDD:238020	28/116 (24%)
		FN3	605..>649	CDD:238020	7/43 (16%)
		FN3	819..908	CDD:238020	23/88 (26%)
		PTKc_InsR_like	972..1261	CDD:173625	3/7 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG4258
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001171
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.810