Protein Alignment CG10702 and ERBB4

DIOPT Version :9

• Sequence 1: NP_001188841.1
• Gene: CG10702 / 35181
• FlyBaseID: FBgn0032752
• Length: 946
• Species: Drosophila melanogaster
• Sequence 2: XP_016859066.1
• Gene: ERBB4 / 2066
• HGNCID: 3432
• Length: 1349
• Species: Homo sapiens
• Alignment Length: 553
• Identity: 123/553 - (22%)
• Similarity: 213/553 - (38%)
• Gaps: 136/553 - (24%)

  Fly    10 VGLMFLALYVPCAESKK-----EHECTSI-DIRNECKNMH-LLDNCTVVTGYVMITLITIEQRCN 67
            |.|:..|..|..::|:.     |::.:|: |:..:.:.:. ..:||.||.|.:.||.|...:..:
Human    11 VSLLVAAGTVQPSDSQSVCAGTENKLSSLSDLEQQYRALRKYYENCEVVMGNLEITSIEHNRDLS 75

  Fly    68 FSEYSYPLLTEITEFMIFTDVRGLVNITEMFP--HLTVIRGRRLFLN-YALGV-TNMHE-----L 123
            |..    .:.|:|.:::..     :|.....|  :|.:|||.:|:.: |||.: .|..:     |
Human    76 FLR----SVREVTGYVLVA-----LNQFRYLPLENLRIIRGTKLYEDRYALAIFLNYRKDGNFGL 131

  Fly   124 EQLVFPKLVAIQRGQVYIGSCPKLCSIGRVNWDLLTLTRGENNIIMVNKNCSTPVCSGC------ 182
            ::|....|..|..|.||:.....||....::|..:......:|:.:|:.|.|    |||
Human   132 QELGLKNLTEILNGGVYVDQNKFLCYADTIHWQDIVRNPWPSNLTLVSTNGS----SGCLAHQDT 192

  Fly   183 --------------------------SSSHCW--SNHYCQRSINENVANPKAN--------INAC 211
                                      .:..||  :.::|| ::...|...:.:        .:.|
Human   193 EKNNPQLLQSLQPFSLITPGGRCHKSCTGRCWGPTENHCQ-TLTRTVCAEQCDGRCYGPYVSDCC 256

  Fly   212 HEECLGGCKNNSSSP--ADCSVCRGLSDDGVCVKSCPK------DKYVME-NYQRCYT-KAECVL 266
            |.||.|||    |.|  .||..|...:|.|.||..||:      ..:.:| |:...|| .|.||.
Human   257 HRECAGGC----SGPKDTDCFACMNFNDSGACVTQCPQTFVYNPTTFQLEHNFNAKYTYGAFCVK 317

  Fly   267 K--HGYVISGSQCVAFCPSGYKTNNRSECVLCSPDEACISFCTPEWPG-------KAFTVYNLAD 322
            |  |.:|:..|.||..|||.......:...:|.|   |...|.....|       .|.||    |
Human   318 KCPHNFVVDSSSCVRACPSSKMEVEENGIKMCKP---CTDICPKACDGIGTGSLMSAQTV----D 375

  Fly   323 AENLR---GCQIFNGSLVITIR-------NKVN--ETQLYQSFTSMREVRGHVKVYR-SSQLRSL 374
            :.|:.   .|...||:|:..:.       |.:.  :.:....|.::||:.|.:.:.. ...:...
Human   376 SSNIDKFINCTKINGNLIFLVTGIHGDPYNAIEAIDPEKLNVFRTVREITGFLNIQSWPPNMTDF 440

  Fly   375 QFLRNLERVHGDPLENRHYSFILYDNKELSELWTPSRQLEFMEGGMFMHRNNKLC---------- 429
            ....||..:.|..|.: ..|.::...:.::.|...|.: |...|.:::..|:.||
Human   441 SVFSNLVTIGGRVLYS-GLSLLILKQQGITSLQFQSLK-EISAGNIYITDNSNLCYYHTINWTTL 503

  Fly   430 ----NRRM-----REFQNAVTHDRALDSLQTND 453
                |:|:     |:.:|........:.|.::|
Human   504 FSTINQRIVIRDNRKAENCTAEGMVCNHLCSSD 536

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG10702	NP_001188841.1	Recep_L_domain	47..159	CDD:279382	32/120 (27%)
		Furin-like	171..297	CDD:279142	44/179 (25%)
		FU	210..258	CDD:238021	20/56 (36%)
		Recep_L_domain	328..441	CDD:279382	25/141 (18%)
ERBB4	XP_016859066.1	None

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S7713
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.860