DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10702 and daf-2

DIOPT Version :9

Sequence 1:	NP_001188841.1	Gene:	CG10702 / 35181	FlyBaseID:	FBgn0032752	Length:	946	Species:	Drosophila melanogaster
Sequence 2:	NP_001299916.1	Gene:	daf-2 / 175410	WormBaseID:	WBGene00000898	Length:	1928	Species:	Caenorhabditis elegans

Alignment Length:	1275	Identity:	255/1275 - (20%)
Similarity:	437/1275 - (34%)	Gaps:	447/1275 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 LMFLALYV---PCAESKKEHECTSIDIRNECKNM-----------------HLLDNCTVVTGYVM 56
            ||.|.|:.   ||| |..|..|..|||||...::                 ..:.|||||.|.:.
Worm   126 LMLLLLFAFVQPCA-SIVEKRCGPIDIRNRPWDIKPQWSKLGDPNEKDLAGQRMVNCTVVEGSLT 189

  Fly    57 ITLI-------------TIEQRCNFSEY-SYPLLTEITEFMIFTDVRGLVNITEMFPHLTVIRGR 107
            |:.:             :::.|.:..|: ::|.|.|||..::..:..|||::.::||:|.||.||
Worm   190 ISFVLKHKTKAQEEMHRSLQPRYSQDEFITFPHLREITGTLLVFETEGLVDLRKIFPNLRVIGGR 254

  Fly   108 RLFLNYALGVTNMHELEQLVFPKLVAIQRGQVYIGSCPKLCSIGRVNWDLLTLTRGENNIIMVNK 172
            .|..:|||.:....:|| :...||..|:.|.|.|....|||....::|..| :|...|::::.|.
Worm   255 SLIQHYALIIYRNPDLE-IGLDKLSVIRNGGVRIIDNRKLCYTKTIDWKHL-ITSSINDVVVDNA 317

  Fly   173 ----------NCSTPVC---SGCSSSH----------------CWSNHYCQRSINENVANP---- 204
                      .|....|   .|.|..|                ||||..||:|...:...|
Worm   318 AEYAVTETGLMCPRGACEEDKGESKCHYLEEKNQEQGVERVQSCWSNTTCQKSCAYDRLLPTKEI 382

  Fly   205 ----KANINACHEECLGGCKNNSSSPADCSVCRGLSDDGVCVKSCPKDKYVMENYQRCYTKAEC- 264
                .||.:.||::|:|||:..:.:.| |..|:.:...|.|::.|....|::.. :||.|:.:|
Worm   383 GPGCDANGDRCHDQCVGGCERVNDATA-CHACKNVYHKGKCIEKCDAHLYLLLQ-RRCVTREQCL 445

  Fly   265 ----VLKHGYV---ISGSQCVAFCPSGYKTN--NRSEC--------VLCSPDEACISFCTPEWPG 312
                ||.:..|   .:...|...||.||:.|  :..||        ::|..:....:|  |:
Worm   446 QLNPVLSNKTVPIKATAGLCSDKCPDGYQINPDDHRECRKCVGKCEIVCEINHVIDTF--PK--- 505

  Fly   313 KAFTVYNLADAENLRGCQIFNGSLVITIRNKVNE---TQLYQSFTSMREVRGHVKVYRSSQLRSL 374
                      |:.:|.|.|.:|:|.|.||.|.:.   ::|...|.::..:.|::.|.:||...||
Worm   506 ----------AQAIRLCNIIDGNLTIEIRGKQDSGMASELKDIFANIHTITGYLLVRQSSPFISL 560

  Fly   375 QFLRNLERVHGDPLENRHYSFILYDNKELSELWTPSRQLEFMEGGMFMHRNNKLCNRRMREFQNA 439
            ...|||.|:....|....|:..:::|..|.:|:..:..|....|.:.:..|..||.:.:::..:.
Worm   561 NMFRNLRRIEAKSLFRNLYAITVFENPNLKKLFDSTTDLTLDRGTVSIANNKMLCFKYIKQLMSK 625

  Fly   440 VTHDRALDSLQ----TNDQEVQCSPLKLQLYVQKRTHRSVKLSWLKSQTSQKIELIHRPLLPGKL 500
            :  :..||.:.    ||.::..|..:.:.:.:......||..||.....:   ::..|..|..:|
Worm   626 L--NIPLDPIDQSEGTNGEKAICEDMAINVSITAVNADSVFFSWPSFNIT---DIDQRKFLGYEL 685

  Fly   501 YHEE---------SELDAPICTRINWKRRLLF------------PDDLIENGTHYLFDLDDLQPD 544
            :.:|         .|.|...|.. :|:.  :|            ||..::.|..     :.::|:
Worm   686 FFKEVPRIDENMTIEEDRSACVD-SWQS--VFKQYYETSNGEPTPDIFMDIGPR-----ERIRPN 742

  Fly   545 TRYVVLLRTFGNDEAHE-AYEARSELTYVQTELDIPKPPLLELVKKTDSSLTV----QMASHDHV 604
            |.|...:.|  ....|. |....|::.:|:|....|.||.|.|.:....::.:    .:..:..:
Worm   743 TLYAYYVAT--QMVLHAGAKNGVSKIGFVRTSYYTPDPPTLALAQVDSDAIHITWEAPLQPNGDL 805

  Fly   605 SFLLTVFELSDDQDYIEQRNYCHQPS---------------YVWQDMDGP----------RWMAY 644
            :....::..::...|.|...:|...|               ...:.:|.|          ..|.:
Worm   806 THYTIMWRENEVSPYEEAEKFCTDASTPANRQHTKDPKETIVADKPVDIPSSRTVAPTLLTMMGH 870

  Fly   645 EDYDDCCA------------QKAEQ-----------FEDSRFIADMREQY---RCTL-------- 675
            ||....||            :.:||           .|.|.|...:.::.   ||.:
Worm   871 EDQQKTCAATPGCCSCSAIEESSEQNKKKRPDPMSAIESSAFENKLLDEVLMPRCDIKNDPVGCA 935

  Fly   676 ---------------DDRE-------QCRRLAHTEVSLPQLR----------------------- 695
                           ||.|       |.|.|.::|:...|.|
Worm   936 MLLLPPEIDDSDVGDDDEEPGGGSEQQQRILRNSEILKRQKRQILGRSLGGIHGIRSIGRKEYEQ 1000

  Fly   696 ----------------------------------------------------------------- 695

Worm  1001 FADMILDTMRVRRSIEDANRVSEELEKAENLGKAPKTLGGKKPLIHISKKKPSSSSTTSTPAPTI 1065

  Fly   696 --------------------------LPGN----------TTEYELKALHRYRLYALQLQACNPL 724
                                      |||:          ...|.::.|..|.|||:.|.||..:
Worm  1066 ASMYALTRKPTTVPGTRIRLYEIYEPLPGSWAINVSALALDNSYVIRNLKHYTLYAISLSACQNM 1130

  Fly   725 -----GCS-SHTTLYGRTNYTMGADLLTQLYACHIPEMDKYI----------------MRFEEPK 767
                 .|| ||..         ||...|:    ||.::||.:                :.::.|.
Worm  1131 TVPGASCSISHRA---------GALKRTK----HITDIDKVLNETIEWRFMNNSQQVNVTWDPPT 1182

  Fly   768 KPNGLVTNYVIHFRNNFSQTHVGCVTRMDHQSAGYMYVKQ-------------INITFTECAVRV 819
            :.||.:..||:..::....:.|  :||......||....|             :::|    |..|
Worm  1183 EVNGGIFGYVVKLKSKVDGSIV--MTRCVGAKRGYSTRNQGVLFQNLADGRYFVSVT----ATSV 1241

  Fly   820 HSLAGDVMTPYMPISLCSDEDRLQAFHSREAKDLSPEITDLPA--TASHGRG-ISIFLICF-LFG 880
            |. ||.                       ||:...|.:...|.  |.....| :.:|||.. :.|
Worm  1242 HG-AGP-----------------------EAESSDPIVVMTPGFFTVEIILGMLLVFLILMSIAG 1282

  Fly   881 CSVSLVWVLYKRRCWRKLPGLRRYVPVREQWLRDRQQTED 920
            |   :::...:.|..:|:..|..::.:..::..|.:...|
Worm  1283 C---IIYYYIQVRYGKKVKALSDFMQLNPEYCVDNKYNAD 1319

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10702	NP_001188841.1	Recep_L_domain	47..159	CDD:279382	40/125 (32%)
		Furin-like	171..297	CDD:279142	44/180 (24%)
		FU	210..258	CDD:238021	13/47 (28%)
		Recep_L_domain	328..441	CDD:279382	30/115 (26%)
daf-2	NP_001299916.1	Recep_L_domain	180..305	CDD:279382	41/126 (33%)
		Furin-like	360..490	CDD:279142	38/131 (29%)
		Recep_L_domain	512..627	CDD:279382	30/116 (26%)
		FN3	776..>832	CDD:238020	8/55 (15%)
		FN3	1169..1255	CDD:238020	20/115 (17%)
		PTKc_InsR_like	1321..1604	CDD:173625
		STYKc	1328..1602	CDD:214568
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	63	1.000	Domainoid score	I6775
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D120934at33208
OrthoFinder	1	1.000	-	-		FOG0001171
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.920