DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10702 and Insr

DIOPT Version :9

Sequence 1:	NP_001188841.1	Gene:	CG10702 / 35181	FlyBaseID:	FBgn0032752	Length:	946	Species:	Drosophila melanogaster
Sequence 2:	NP_001316985.1	Gene:	Insr / 16337	MGIID:	96575	Length:	1384	Species:	Mus musculus

Alignment Length:	1013	Identity:	264/1013 - (26%)
Similarity:	429/1013 - (42%)	Gaps:	212/1013 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 CTSIDIRNECKNMHLLDNCTVVTGYVMITLITIEQRCNFSEYSYPLLTEITEFMIFTDVRGLVNI 94
            |..:||||....:|.|:||:|:.|::.|.|:...:..:|.:.|:|.|..||::::...|.||.::
Mouse    35 CPGMDIRNNLTRLHELENCSVIEGHLQILLMFKTRPEDFRDLSFPKLIMITDYLLLFRVYGLESL 99

  Fly    95 TEMFPHLTVIRGRRLFLNYALGVTNMHELEQLVFPKLVAIQRGQVYIGSCPKLCSIGRVNWDLLT 159
            .::||:||||||.|||.||||.:..|..|::|....|:.|.||.|.|....:||.:..::|..:
Mouse   100 KDLFPNLTVIRGSRLFFNYALVIFEMVHLKELGLYNLMNITRGSVRIEKNNELCYLATIDWSRI- 163

  Fly   160 LTRGENNIIMVNK------------------NCSTPVCSGCSSSHCWSNHYCQRSINENVANP-- 204
            |...|:|.|::||                  ||...|.:|.....||::.:||: :...:...
Mouse   164 LDSVEDNYIVLNKDDNEECGDVCPGTAKGKTNCPATVINGQFVERCWTHSHCQK-VCPTICKSHG 227

  Fly   205 -KANINACHEECLGGCKNNSSSPADCSVCRGLSDDGVCVKSCPKDKYVMENYQRCYT-------- 260
             .|....||:||||.| :....|..|..||....||.||::||...|..::: ||..
Mouse   228 CTAEGLCCHKECLGNC-SEPDDPTKCVACRNFYLDGQCVETCPPPYYHFQDW-RCVNFSFCQDLH 290

  Fly   261 -------KAECVLKHGYVISGSQCVAFCPSGYKTNNRSECVLCSPDEACISFCTPE----WPGKA 314
                   |..|   |.|||..::|:..|||||..|  |..::|:|   |:..| |:    ..|:.
Mouse   291 FKCRNSRKPGC---HQYVIHNNKCIPECPSGYTMN--SSNLMCTP---CLGPC-PKVCQILEGEK 346

  Fly   315 FTVYNLADAENLRGCQIFNGSLVITIRNKVN-ETQLYQSFTSMREVRGHVKVYRSSQLRSLQFLR 378
             |:.::..|:.||||.:.||||:|.||...| ..:|..:...:.|:.|.:|:.||..|.||.|.|
Mouse   347 -TIDSVTSAQELRGCTVINGSLIINIRGGNNLAAELEANLGLIEEISGFLKIRRSYALVSLSFFR 410

  Fly   379 NLERVHGDPLENRHYSFILYDNKELSELWTPSR-QLEFMEGGMFMHRNNKLC---NRRMREFQNA 439
            .|..:.|:.||..:|||...||:.|.:||..|: .|...:|.:|.|.|.|||   ..:|.|....
Mouse   411 KLHLIRGETLEIGNYSFYALDNQNLRQLWDWSKHNLTITQGKLFFHYNPKLCLSEIHKMEEVSGT 475

  Fly   440 VTHDRALD-SLQTNDQEVQCSPLKLQLYVQKRTHRSVKLSWLKSQTSQKIELIHRPLLPGKLYHE 503
            .......| :|:||..:..|....|:....:.:...:.|.|.......     .|.||...|:::
Mouse   476 KGRQERNDIALKTNGDQASCENELLKFSFIRTSFDKILLRWEPYWPPD-----FRDLLGFMLFYK 535

  Fly   504 E------SELDA-PICTRINWKRRLLFP-----DDLIENGTHYLFDLDDLQPDTRYVVLLRTF-- 554
            |      :|.|. ..|...:|....:.|     |...:..:|..:.:..|:|.|:|.:.::|.
Mouse   536 EAPYQNVTEFDGQDACGSNSWTVVDIDPPQRSNDPKSQTPSHPGWLMRGLKPWTQYAIFVKTLVT 600

  Fly   555 GNDEAHEAYEARSELTYVQTELDIPKPPLLEL-VKKTDSSLTVQMA----SHDHVSFLLTVFELS 614
            .:|| ...|.|:|::.||||:...|..||..: |..:.|.:.::..    .:.:::..|..:|..
Mouse   601 FSDE-RRTYGAKSDIIYVQTDATNPSVPLDPISVSNSSSQIILKWKPPSDPNGNITHYLVYWERQ 664

  Fly   615 DDQDYIEQRNYCHQ----PSYVWQ---DMDGPRWMAYEDYDD----CCAQKAEQFEDSRFIADMR 668
            .:...:.:.:||.:    ||..|.   :.|..:.....:|||    ||:...   .||:.:.::.
Mouse   665 AEDSELFELDYCLKGLKLPSRTWSPPFESDDSQKHNQSEYDDSASECCSCPK---TDSQILKELE 726

  Fly   669 E-QYRCTLDD-----------------------------REQCRRLAHTEVSLPQLR------LP 697
            | .:|.|.:|                             .|:...:..|.::||...      :|
Mouse   727 ESSFRKTFEDYLHNVVFVPRKTSSGNGAEDSRPSRKRRSLEEVGNVTATTLTLPDFPNVSSTIVP 791

  Fly   698 GNTTEYE------------LKALHRYRLYALQLQACNPLG----CSSHTTLYGRTNYTMGADLLT 746
            .:..|:.            :..|..:..|.::|||||...    ||....:..||.....||.:.
Mouse   792 TSQEEHRPFEKVVNKESLVISGLRHFTGYRIELQACNQDSPDERCSVAAYVSARTMPEAKADDIV 856

  Fly   747 QLYACHIPEMDKYIMRFEEPKKPNGLVTNYVIHFRNN--------FSQTHV----GCVTRMDHQS 799
            ......|.|.:...:.::|||:||||:..|.:.:|..        .|:.|.    ||  |:...|
Mouse   857 GPVTHEIFENNVVHLMWQEPKEPNGLIVLYEVSYRRYGDEELHLCVSRKHFALERGC--RLRGLS 919

  Fly   800 AGYMYVKQINITFTECAVRVHSLAGD---------VMTPYMPISLCSDEDRLQAFHSREAKDLSP 855
            .|...|:          ||..||||:         .:|.|:.:.            |..||.:
Mouse   920 PGNYSVR----------VRATSLAGNGSWTEPTYFYVTDYLDVP------------SNIAKII-- 960

  Fly   856 EITDLPATASHGRGISIFLICFLFGCSVSLVWVLYKRR 893
                          |...:..|||...:..:::..::|
Mouse   961 --------------IGPLIFVFLFSVVIGSIYLFLRKR 984

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10702	NP_001188841.1	Recep_L_domain	47..159	CDD:279382	42/111 (38%)
		Furin-like	171..297	CDD:279142	45/161 (28%)
		FU	210..258	CDD:238021	18/47 (38%)
		Recep_L_domain	328..441	CDD:279382	44/117 (38%)
Insr	NP_001316985.1	Recep_L_domain	52..164	CDD:279382	42/112 (38%)
		Furin-like	179..337	CDD:279142	47/169 (28%)
		FU	234..281	CDD:238021	19/48 (40%)
		Recep_L_domain	359..472	CDD:279382	43/112 (38%)
		FN3	624..>667	CDD:238020	7/42 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	688..709		4/20 (20%)
		Insulin-binding. /evidence=ECO:0000250	735..743		1/7 (14%)
		FN3	869..946	CDD:238020	23/88 (26%)
		Important for interaction with IRS1, SHC1 and STAT5B. /evidence=ECO:0000250	998..1001
		PTKc_InsR	1018..1305	CDD:133192
		Pkinase_Tyr	1025..1292	CDD:285015
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1361..1384
		PIK3R1 binding. /evidence=ECO:0000250	1363..1366
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG4258
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D120934at33208
OrthoFinder	1	1.000	-	-		FOG0001171
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.820