Protein Alignment CG10702 and Igf1r

DIOPT Version :10

• Sequence 1: NP_724157.1
• Gene: CG10702 / 35181
• FlyBaseID: FBgn0032752
• Length: 946
• Species: Drosophila melanogaster
• Sequence 2: XP_006540704.1
• Gene: Igf1r / 16001
• MGIID: 96433
• Length: 1401
• Species: Mus musculus
• Alignment Length: 1045
• Identity: 272/1045 - (26%)
• Similarity: 447/1045 - (42%)
• Gaps: 184/1045 - (17%)

  Fly    11 GLMFLALYVPCAESKKEHECTSIDIRNECKNMHLLDNCTVVTGYVMITLITIEQRCNFSEYSYPL 75
            ||:||:..:....:..|.....|||||:.:.:..|:||||:.|::.|.||:..:  ::..|.:|.
Mouse    15 GLVFLSAALSLWPTSGEICGPGIDIRNDYQQLKRLENCTVIEGFLHILLISKAE--DYRSYRFPK 77

  Fly    76 LTEITEFMIFTDVRGLVNITEMFPHLTVIRGRRLFLNYALGVTNMHELEQLVFPKLVAIQRGQVY 140
            ||.|||:::...|.||.::.::||:||||||.:||.||||.:..|..|:.:....|..|.||.:.
Mouse    78 LTVITEYLLLFRVAGLESLGDLFPNLTVIRGWKLFYNYALVIFEMTNLKDIGLYNLRNITRGAIR 142

  Fly   141 IGSCPKLCSIGRVNWDLLTLTRGENNIIMVN---KNC---------STPVCSGCSSSH-----CW 188
            |.....||.:..::|.|: |....||.|:.|   |.|         ..|:|...:.::     ||
Mouse   143 IEKNADLCYLSTIDWSLI-LDAVSNNYIVGNKPPKECGDLCPGTLEEKPMCEKTTINNEYNYRCW 206

  Fly   189 SNHYCQRSINENVANPKA---NINACHEECLGGCKNNSSSPAD---CSVCRGLSDDGVCVKSCPK 247
            :.:.||: :..:|...:|   |...||.||||.|    .:|.|   |..||.....||||.:||.
Mouse   207 TTNRCQK-MCPSVCGKRACTENNECCHPECLGSC----HTPDDNTTCVACRHYYYKGVCVPACPP 266

  Fly   248 DKYVMENYQRCYTK--------AECVLKHGYVISGSQCVAFCPSGYKTNNRSECVLCSPDEA-CI 303
            ..|..|.: ||..:        ||.....|:||...:|:..||||: ..|.::.:.|.|.|. |.
Mouse   267 GTYRFEGW-RCVDRDFCANIPNAESSDSDGFVIHDDECMQECPSGF-IRNSTQSMYCIPCEGPCP 329

  Fly   304 SFCTPEWPGKAFTVYNLADAENLRGCQIFNGSLVITIRNKVNETQLYQSFTSMRE-VRGHVKVYR 367
            ..|..| ..|..|:.::..|:.|:||.|..|:|:|.||...|.....::|..:.| |.|:||:..
Mouse   330 KVCGDE-EKKTKTIDSVTSAQMLQGCTILKGNLLINIRRGNNIASELENFMGLIEVVTGYVKIRH 393

  Fly   368 SSQLRSLQFLRNLERVHGDPLENRHYSFILYDNKELSELWT-PSRQLEFMEGGMFMHRNNKLCNR 431
            |..|.||.||:||..:.|:.....:|||.:.||:.|.:||. ..|.|....|.|:...|.|||..
Mouse   394 SHALVSLSFLKNLRLILGEEQLEGNYSFYVLDNQNLQQLWDWNHRNLTVRSGKMYFAFNPKLCVS 458

  Fly   432 ---RMREFQNAVTHDRALDS-----LQTNDQEVQCSPLKLQLYVQKRTHRSVKLSWLKSQTSQKI 488
               ||.|    ||..:...|     .:.|.:...|....|:..........:.::|.:.:...
Mouse   459 EIYRMEE----VTGTKGRQSKGDINTRNNGERASCESDVLRFTSTTTWKNRIIITWHRYRPPD-- 517

  Fly   489 ELIHRPLLPGKLYHEE------SELDA-PICTRINWKRRLLFPDDLIEN--GTHYLFDLDDLQPD 544
               :|.|:...:|::|      :|.|. ..|...:|.   :...||..|  |...:. |..|:|.
Mouse   518 ---YRDLISFTVYYKEAPFKNVTEYDGQDACGSNSWN---MVDVDLPPNKEGEPGIL-LHGLKPW 575

  Fly   545 TRYVVLLR--TFGNDEAHEAYEARSELTYVQTELDIPKPPLLELVKKTDSSLTV-----QMASHD 602
            |:|.|.::  |....|......|:||:.|::|...:|..||..|.....||..:     ....:.
Mouse   576 TQYAVYVKAVTLTMVENDHIRGAKSEILYIRTNASVPSIPLDVLSASNSSSQLIVKWNPPTLPNG 640

  Fly   603 HVSFLLTVFELSDDQDYIEQRNYCHQ----PSYVWQD--------MDGPRW-MAYEDYDDCCA-- 652
            ::|:.:..::......|:.:.|||.:    |...:.|        .:.|:. :...|...|||
Mouse   641 NLSYYIVRWQRQPQDGYLYRHNYCSKADKIPIRKYADGTIDVEEVTENPKTEVCGGDKGPCCACP 705

  Fly   653 -----QKAEQFE------------DSRFI-------ADMREQYRCTLDDREQCRRLAHT------ 687
                 ::||:.|            :|.|:       .|:.:....|:..|.:...:|.|
Mouse   706 KTEAEKQAEKEEAEYRKVFENFLHNSIFVPRPERRRRDVMQVANTTMSSRSRNTTVADTYNITDP 770

  Fly   688 ---EVSLP--QLRLPGNTTEYELKALHRYRLYALQLQACN----PLGCSSHTTLYGRTNYTMGAD 743
               |...|  :.|: .|.....:..|..:.||.:.:.:||    .||||:...::.||....|||
Mouse   771 EEFETEYPFFESRV-DNKERTVISNLRPFTLYRIDIHSCNHEAEKLGCSASNFVFARTMPAEGAD 834

  Fly   744 LLTQLYACHIPEMDKYIMRFEEPKKPNGLVTNYVIHFRNNFSQTHVGCVTRMDHQSAGYMYVKQI 808
            .:...........:...:::.||:.||||:..|.|.:.:...... .||:|.:::..|...:.::
Mouse   835 DIPGPVTWEPRPENSIFLKWPEPENPNGLILMYEIKYGSQVEDQR-ECVSRQEYRKYGGAKLNRL 898

  Fly   809 NITFTECAVRVHSLAG-----DVMTPYMPISLCSDEDRLQAFHSREAKDLSPEITDLPATASHGR 868
            |.......::..||:|     |.:..|:|.....:             :....|..||
Mouse   899 NPGNYTARIQATSLSGNGSWTDPVFFYVPAKTTYE-------------NFMHLIIALP------- 943

  Fly   869 GISIFLICFLFGCSVSLVWVLYKRRCWRKL--------------PGLRRYVPVREQWLRDRQQ-T 918
             ::|.||   .|..|.:::|.:::|...:|              .....|||  ::|...|:: |
Mouse   944 -VAILLI---VGGLVIMLYVFHRKRNNSRLGNGVLYASVNPEYFSAADVYVP--DEWEVAREKIT 1002

  Fly   919 EDREI 923
            .:||:
Mouse  1003 MNREL 1007

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG10702	NP_724157.1	Recep_L_domain	47..159	CDD:460032	43/111 (39%)
		Furin-like	171..297	CDD:395614	45/156 (29%)
		Recep_L_domain	328..441	CDD:460032	43/117 (37%)
Igf1r	XP_006540704.1	Recep_L_domain	51..161	CDD:460032	43/112 (38%)
		Furin-like	175..330	CDD:395614	48/161 (30%)
		Recep_L_domain	353..468	CDD:460032	44/118 (37%)
		FN3	494..607	CDD:238020	26/121 (21%)
		FN3	612..>656	CDD:238020	7/43 (16%)
		FN3	837..926	CDD:238020	17/89 (19%)
		PTKc_InsR_like	994..1302	CDD:173625	5/14 (36%)