DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10702 and Igf1r

DIOPT Version :9

Sequence 1:	NP_001188841.1	Gene:	CG10702 / 35181	FlyBaseID:	FBgn0032752	Length:	946	Species:	Drosophila melanogaster
Sequence 2:	XP_006540704.1	Gene:	Igf1r / 16001	MGIID:	96433	Length:	1401	Species:	Mus musculus

Alignment Length:	1045	Identity:	272/1045 - (26%)
Similarity:	447/1045 - (42%)	Gaps:	184/1045 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 GLMFLALYVPCAESKKEHECTSIDIRNECKNMHLLDNCTVVTGYVMITLITIEQRCNFSEYSYPL 75
            ||:||:..:....:..|.....|||||:.:.:..|:||||:.|::.|.||:..:  ::..|.:|.
Mouse    15 GLVFLSAALSLWPTSGEICGPGIDIRNDYQQLKRLENCTVIEGFLHILLISKAE--DYRSYRFPK 77

  Fly    76 LTEITEFMIFTDVRGLVNITEMFPHLTVIRGRRLFLNYALGVTNMHELEQLVFPKLVAIQRGQVY 140
            ||.|||:::...|.||.::.::||:||||||.:||.||||.:..|..|:.:....|..|.||.:.
Mouse    78 LTVITEYLLLFRVAGLESLGDLFPNLTVIRGWKLFYNYALVIFEMTNLKDIGLYNLRNITRGAIR 142

  Fly   141 IGSCPKLCSIGRVNWDLLTLTRGENNIIMVN---KNC---------STPVCSGCSSSH-----CW 188
            |.....||.:..::|.|: |....||.|:.|   |.|         ..|:|...:.::     ||
Mouse   143 IEKNADLCYLSTIDWSLI-LDAVSNNYIVGNKPPKECGDLCPGTLEEKPMCEKTTINNEYNYRCW 206

  Fly   189 SNHYCQRSINENVANPKA---NINACHEECLGGCKNNSSSPAD---CSVCRGLSDDGVCVKSCPK 247
            :.:.||: :..:|...:|   |...||.||||.|    .:|.|   |..||.....||||.:||.
Mouse   207 TTNRCQK-MCPSVCGKRACTENNECCHPECLGSC----HTPDDNTTCVACRHYYYKGVCVPACPP 266

  Fly   248 DKYVMENYQRCYTK--------AECVLKHGYVISGSQCVAFCPSGYKTNNRSECVLCSPDEA-CI 303
            ..|..|.: ||..:        ||.....|:||...:|:..||||: ..|.::.:.|.|.|. |.
Mouse   267 GTYRFEGW-RCVDRDFCANIPNAESSDSDGFVIHDDECMQECPSGF-IRNSTQSMYCIPCEGPCP 329

  Fly   304 SFCTPEWPGKAFTVYNLADAENLRGCQIFNGSLVITIRNKVNETQLYQSFTSMRE-VRGHVKVYR 367
            ..|..| ..|..|:.::..|:.|:||.|..|:|:|.||...|.....::|..:.| |.|:||:..
Mouse   330 KVCGDE-EKKTKTIDSVTSAQMLQGCTILKGNLLINIRRGNNIASELENFMGLIEVVTGYVKIRH 393

  Fly   368 SSQLRSLQFLRNLERVHGDPLENRHYSFILYDNKELSELWT-PSRQLEFMEGGMFMHRNNKLCNR 431
            |..|.||.||:||..:.|:.....:|||.:.||:.|.:||. ..|.|....|.|:...|.|||..
Mouse   394 SHALVSLSFLKNLRLILGEEQLEGNYSFYVLDNQNLQQLWDWNHRNLTVRSGKMYFAFNPKLCVS 458

  Fly   432 ---RMREFQNAVTHDRALDS-----LQTNDQEVQCSPLKLQLYVQKRTHRSVKLSWLKSQTSQKI 488
               ||.|    ||..:...|     .:.|.:...|....|:..........:.::|.:.:...
Mouse   459 EIYRMEE----VTGTKGRQSKGDINTRNNGERASCESDVLRFTSTTTWKNRIIITWHRYRPPD-- 517

  Fly   489 ELIHRPLLPGKLYHEE------SELDA-PICTRINWKRRLLFPDDLIEN--GTHYLFDLDDLQPD 544
               :|.|:...:|::|      :|.|. ..|...:|.   :...||..|  |...:. |..|:|.
Mouse   518 ---YRDLISFTVYYKEAPFKNVTEYDGQDACGSNSWN---MVDVDLPPNKEGEPGIL-LHGLKPW 575

  Fly   545 TRYVVLLR--TFGNDEAHEAYEARSELTYVQTELDIPKPPLLELVKKTDSSLTV-----QMASHD 602
            |:|.|.::  |....|......|:||:.|::|...:|..||..|.....||..:     ....:.
Mouse   576 TQYAVYVKAVTLTMVENDHIRGAKSEILYIRTNASVPSIPLDVLSASNSSSQLIVKWNPPTLPNG 640

  Fly   603 HVSFLLTVFELSDDQDYIEQRNYCHQ----PSYVWQD--------MDGPRW-MAYEDYDDCCA-- 652
            ::|:.:..::......|:.:.|||.:    |...:.|        .:.|:. :...|...|||
Mouse   641 NLSYYIVRWQRQPQDGYLYRHNYCSKADKIPIRKYADGTIDVEEVTENPKTEVCGGDKGPCCACP 705

  Fly   653 -----QKAEQFE------------DSRFI-------ADMREQYRCTLDDREQCRRLAHT------ 687
                 ::||:.|            :|.|:       .|:.:....|:..|.:...:|.|
Mouse   706 KTEAEKQAEKEEAEYRKVFENFLHNSIFVPRPERRRRDVMQVANTTMSSRSRNTTVADTYNITDP 770

  Fly   688 ---EVSLP--QLRLPGNTTEYELKALHRYRLYALQLQACN----PLGCSSHTTLYGRTNYTMGAD 743
               |...|  :.|: .|.....:..|..:.||.:.:.:||    .||||:...::.||....|||
Mouse   771 EEFETEYPFFESRV-DNKERTVISNLRPFTLYRIDIHSCNHEAEKLGCSASNFVFARTMPAEGAD 834

  Fly   744 LLTQLYACHIPEMDKYIMRFEEPKKPNGLVTNYVIHFRNNFSQTHVGCVTRMDHQSAGYMYVKQI 808
            .:...........:...:::.||:.||||:..|.|.:.:...... .||:|.:::..|...:.::
Mouse   835 DIPGPVTWEPRPENSIFLKWPEPENPNGLILMYEIKYGSQVEDQR-ECVSRQEYRKYGGAKLNRL 898

  Fly   809 NITFTECAVRVHSLAG-----DVMTPYMPISLCSDEDRLQAFHSREAKDLSPEITDLPATASHGR 868
            |.......::..||:|     |.:..|:|.....:             :....|..||
Mouse   899 NPGNYTARIQATSLSGNGSWTDPVFFYVPAKTTYE-------------NFMHLIIALP------- 943

  Fly   869 GISIFLICFLFGCSVSLVWVLYKRRCWRKL--------------PGLRRYVPVREQWLRDRQQ-T 918
             ::|.||   .|..|.:::|.:::|...:|              .....|||  ::|...|:: |
Mouse   944 -VAILLI---VGGLVIMLYVFHRKRNNSRLGNGVLYASVNPEYFSAADVYVP--DEWEVAREKIT 1002

  Fly   919 EDREI 923
            .:||:
Mouse  1003 MNREL 1007

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10702	NP_001188841.1	Recep_L_domain	47..159	CDD:279382	43/111 (39%)
		Furin-like	171..297	CDD:279142	45/156 (29%)
		FU	210..258	CDD:238021	20/50 (40%)
		Recep_L_domain	328..441	CDD:279382	43/117 (37%)
Igf1r	XP_006540704.1	Recep_L_domain	51..159	CDD:366426	42/109 (39%)
		Furin-like	175..332	CDD:366287	48/163 (29%)
		Recep_L_domain	353..466	CDD:366426	43/116 (37%)
		FN3	494..607	CDD:238020	26/121 (21%)
		FN3	612..>656	CDD:238020	7/43 (16%)
		FN3	837..926	CDD:238020	17/89 (19%)
		PTKc_InsR_like	994..1302	CDD:173625	5/14 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG4258
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D120934at33208
OrthoFinder	1	1.000	-	-		FOG0001171
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.820