DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10702 and insrr

DIOPT Version :9

Sequence 1:	NP_001188841.1	Gene:	CG10702 / 35181	FlyBaseID:	FBgn0032752	Length:	946	Species:	Drosophila melanogaster
Sequence 2:	XP_004917407.2	Gene:	insrr / 100490498	XenbaseID:	XB-GENE-483108	Length:	1360	Species:	Xenopus tropicalis

Alignment Length:	946	Identity:	242/946 - (25%)
Similarity:	410/946 - (43%)	Gaps:	156/946 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 GNMLLGVGL--MFLALYVPCAESKKEHECTSIDIRNECKNMHLLDNCTVVTGYVMITLITIEQRC 66
            |::|:...|  :.|.|.|........|.|.|:||||:......|:||||:.|.:.|.|:...:..
Frog     5 GSLLVPSCLKGVLLILLVFNTNGDATHFCGSMDIRNDVSQFRKLENCTVIQGNLQILLMFSTKPE 69

  Fly    67 NFSEYSYPLLTEITEFMIFTDVRGLVNITEMFPHLTVIRGRRLFLNYALGVTNMHELEQLVFPKL 131
            :|....:..||.|||:::...|.||.::.::||:|::|||..||.:|:|.:..|..|..:....|
Frog    70 DFRGLRFERLTMITEYLLLFRVYGLESLRDLFPNLSIIRGTDLFFHYSLVIFEMPHLRDIGLHSL 134

  Fly   132 VAIQRGQVYIGSCPKLCSIGRVNWDLLTLTRGENNIIMVNK-----------------NC-STPV 178
            ..|..|.|.|....:||.|..::|.||: ...|||.|:.||                 :| .||:
Frog   135 TNILNGAVRIERNQELCHISTIDWSLLS-ESVENNYIVGNKPVEECADVCPGIRDSGESCIKTPI 198

  Fly   179 CSGCSSSHCWSNHYCQR--SINENVANPKANINACHEECLGGCKNNSSSPADCSVCRGLSDDGVC 241
             :|...|.||::..||:  ...|::|..... ..||.|||||| |.:..|..|..||....|..|
Frog   199 -NGNMESRCWTSTSCQKVCPCKEDIACSNTG-ECCHPECLGGC-NKAGDPRACVACRNFYIDDQC 260

  Fly   242 VKSCPKDKYVMENYQRCYTKAEC--VLKHG-------YVISGSQCVAFCPSGYKTNNRSECVLCS 297
            :.|||...:..|.: ||..:|.|  :||..       :||..::|::.|||||..|:.|  :.|
Frog   261 LPSCPPGTFEYEGW-RCIEEAYCGNLLKESENSESTKFVIFENRCLSECPSGYTRNDSS--IFC- 321

  Fly   298 PDEACISFCTPEWPGKAFTVYNLADAENLRGCQIFNGSLVITIRNKVN-ETQLYQSFTSMREVRG 361
              ..|...|..........:.:|..|:.|.||....|:|::.||...| .::|.||...:..:.|
Frog   322 --HKCEGLCPKTCKAGNKVIDSLEAAKELTGCTNIEGNLILNIRRGHNLASELQQSLGLIETITG 384

  Fly   362 HVKVYRSSQLRSLQFLRNLERVHGDPLENRHYSFILYDNKELSELWTPSRQLEFMEGGMFMHRNN 426
            .:|:..|..|.||.|.:||:.:.||.:.:.:|:..:.||:.|.:|||| ..|....|.::...|.
Frog   385 FLKIKHSFALVSLSFFKNLKLIRGDTMVDGNYTLYILDNQNLLQLWTP-ESLSIPVGKLYFAFNP 448

  Fly   427 KLCNRRMREFQNAVTHDRALDSL-----QTNDQEVQCS--PLKLQLYVQKRTHRS-VKLSWLKSQ 483
            |||...:...:. :|..|...:.     :||..:..|:  ||:   :|...|... :.|.|.:.|
Frog   449 KLCLSEIYHMEE-ITGTRGRQNKADINPRTNGDQASCNIRPLR---FVSNWTEADRINLKWERYQ 509

  Fly   484 TSQKIELIHRPLLPGKLYHEESE-------LDAPICTRINWKRRLLFPDDLIENGTHYLFDLDDL 541
            ..      ...||...::::||.       |....|...:|  .::..:..:.|.......|.:|
Frog   510 PP------GHDLLSFVVHYKESPFQNITEYLGQDACGANSW--NVVDVELPLNNEQEPSVTLTNL 566

  Fly   542 QPDTRYVVLLR--TFGNDEAHEAYEARSELTYVQTELDIPKPPL-LELVKKTDSSLTVQ----MA 599
            :|..:|.:.:|  |...:|....:.|:|::.|::|....|..|. :.::..:.|.|.|:    ..
Frog   567 KPWVQYAIYVRAITLTAEENGRKFGAQSDVVYIRTRPAAPTVPQDVMIMSNSSSHLIVRWKPPTQ 631

  Fly   600 SHDHVSFLLTVFE--LSDDQDYIEQRNYCHQ---------PSYVWQDMDGPRWMAYEDYDDCC-- 651
            .:.::::.|.:::  :.|.:.|:  .|||.:         .:....|.:|.:....:..|.||
Frog   632 RNGNLTYYLVLWQQMVEDKELYL--NNYCTKGLKLPTSSADTRFDNDDNGNQDPNQDTEDKCCPC 694

  Fly   652 ---------------AQKAEQF-EDSRFIADMREQYRCTL---DDREQCRRLAHTEVSLPQL--- 694
                           .:|.|.| .::.||.  :..::.||   |::...:|........|::
Frog   695 QKDGGLHPEMDEGSFQKKFENFLRNTIFIP--KPPWKVTLINKDNQRAPKRRRDVPGMNPEVLGN 757

  Fly   695 -RLPGNTTEYE-----------------------LKALHRYRLYALQLQACNP----LGCSSHTT 731
             .||..|..:.                       :..|..:..|.:.:.|||.    :|||:.|.
Frog   758 ASLPEGTVSHTINHTGVDSKPYSYKDKVFLNRMVISNLRHFTEYRIDIHACNHAAEIVGCSAATF 822

  Fly   732 LYGRTNYTMGADLLTQLYACHIPEMDKYIMRFEEPKKPNGLVTNYVIHFRNNFSQ--THVGCVTR 794
            ::.||.....||.:.......:...:..:|::||||.||||:..|.|.::.:..:  ..|.||:|
Frog   823 VFARTMQDPLADNIVGNITWEVTAKNAILMKWEEPKNPNGLILKYEIKYKRDHEEGPPTVVCVSR 887

  Fly   795 MDHQSAGYMYVKQINITFTE-----CAVRVHSLAGD 825
            ...|.     .|.:::|..:     ..:|..||||:
Frog   888 QQFQR-----YKGVHLTLLQPGNYSARIRATSLAGN 918

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10702	NP_001188841.1	Recep_L_domain	47..159	CDD:279382	38/111 (34%)
		Furin-like	171..297	CDD:279142	48/154 (31%)
		FU	210..258	CDD:238021	19/47 (40%)
		Recep_L_domain	328..441	CDD:279382	35/113 (31%)
insrr	XP_004917407.2	Recep_L_domain	50..161	CDD:395817	37/110 (34%)
		Furin-like	177..330	CDD:395614	49/161 (30%)
		Recep_L_domain	350..456	CDD:395817	35/106 (33%)
		FN3	492..601	CDD:238020	23/116 (20%)
		FN3	606..>650	CDD:238020	6/43 (14%)
		FN3	837..927	CDD:238020	23/87 (26%)
		PTKc_InsR_like	999..1275	CDD:173625
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D120934at33208
OrthoFinder	1	1.000	-	-		FOG0001171
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.010