DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10495 and Dus2

DIOPT Version :9

Sequence 1:	NP_609939.1	Gene:	CG10495 / 35179	FlyBaseID:	FBgn0032750	Length:	396	Species:	Drosophila melanogaster
Sequence 2:	NP_079794.1	Gene:	Dus2 / 66369	MGIID:	1913619	Length:	493	Species:	Mus musculus

Alignment Length:	336	Identity:	85/336 - (25%)
Similarity:	146/336 - (43%)	Gaps:	44/336 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 VSAPMVRYSKLEFRRLVRLNGVQLAFTPMMISDSINNSEKARQNEFST----GADDQ-------- 78
            :.|||||...|..|.|....|..:.:...:|...:...::......||    ..||:
Mouse    15 ILAPMVRVGTLPMRLLALDYGADIVYCEELIDLKMLQCKRVVNEVLSTVDFVAPDDRVVFRTCER 79

  Fly    79 ---PLIAQFAAKDPTEFVTSAQLIYPYVDGIDLNCGCPQSWAMAKGYGCGMLRQPELVHQVVQE- 139
               .::.|....|....:..|:|:...|.|||:|.|||:.::...|.|..:|..|:.:.:::..
Mouse    80 EQSRVVFQMGTSDAERALAVARLVENDVAGIDVNMGCPKEYSTKGGMGAALLSDPDKIEKILSTL 144

  Fly   140 VRRTLPGDFSVSVKMRLLGGEESLQRTIDLARQLESAGVTFLTLHGRTPAQKHSKDTLDIPAMSQ 204
            |:.|   ...|:.|:|:|   .||:.|::|.:::|..|::.:.:|||. ..:..:..:....:..
Mouse   145 VKGT---HRPVTCKIRIL---PSLEDTLNLVKRIERTGISAIAVHGRN-RDERPQHPVSCEVIRA 202

  Fly   205 VRQSLQIPLIVNG----NVESYRDACDMHEQTGAAGVMAARGLLANPALFNSNYPDGKTTPLSCV 265
            :.::|.||:|.||    :::.:.|..|..:.|.|:.||.||..:.||::|   ..|| ..||..|
Mouse   203 IAETLSIPVIANGGSHDHIQQHVDIEDFRQATAASSVMVARAAMWNPSIF---LKDG-LRPLEEV 263

  Fly   266 QQWLDIASAAGDNLLFQCFHHHLTFMYSAQMKRDL------RVQFNSLGSKEQVVDF-LKEHYNL 323
            .|.....:...||      |:..|.....||.|:.      |:...:..|:|....| |...|..
Mouse   264 MQKYIRYAVQYDN------HYTNTKYCLCQMLREQLESPQGRLLHAAQSSQEICEAFGLGAFYEE 322

  Fly   324 EYSEVDPPSAD 334
            ...|:|...||
Mouse   323 TIRELDARRAD 333

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10495	NP_609939.1	DUS_like_FMN	26..251	CDD:239200	61/244 (25%)
CG10495	NP_609939.1	Dus	28..321	CDD:279540	80/319 (25%)
Dus2	NP_079794.1	Catalytic domain. /evidence=ECO:0000250\|UniProtKB:Q9NX74	1..333		83/334 (25%)
		DUS_like_FMN	13..252	CDD:239200	61/243 (25%)
		Interaction with tRNA. /evidence=ECO:0000250\|UniProtKB:Q9NX74	367..371
		DSRM_DUS2L	369..436	CDD:380700
		Interaction with tRNA. /evidence=ECO:0000250\|UniProtKB:Q9NX74	420..424
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	438..472
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0042
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810