DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10495 and DUS2

DIOPT Version :9

Sequence 1:	NP_609939.1	Gene:	CG10495 / 35179	FlyBaseID:	FBgn0032750	Length:	396	Species:	Drosophila melanogaster
Sequence 2:	NP_001258691.1	Gene:	DUS2 / 54920	HGNCID:	26014	Length:	493	Species:	Homo sapiens

Alignment Length:	376	Identity:	88/376 - (23%)
Similarity:	151/376 - (40%)	Gaps:	77/376 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 VSAPMVRYSKLEFRRLVRLNGVQLAFTPMMISDSINNSEKARQNEFST----GADDQ-------- 78
            :.|||||...|..|.|....|..:.:...:|...:...::......||    ..||:
Human    15 ILAPMVRVGTLPMRLLALDYGADIVYCEELIDLKMIQCKRVVNEVLSTVDFVAPDDRVVFRTCER 79

  Fly    79 ---PLIAQFAAKDPTEFVTSAQLIYPYVDGIDLNCGCPQSWAMAKGYGCGMLRQPELVHQV---- 136
               .::.|....|....:..|:|:...|.|||:|.|||:.::...|.|..:|..|:.:.::
Human    80 EQNRVVFQMGTSDAERALAVARLVENDVAGIDVNMGCPKQYSTKGGMGAALLSDPDKIEKILSTL 144

  Fly   137 VQEVRRTLPGDFSVSVKMRLLGGEESLQRTIDLARQLESAGVTFLTLHGRTPAQKHSKDTLDIPA 201
            |:..||      .|:.|:|:|   .||:.|:.|.:::|..|:..:.:||| ..::..:..:....
Human   145 VKGTRR------PVTCKIRIL---PSLEDTLSLVKRIERTGIAAIAVHGR-KREERPQHPVSCEV 199

  Fly   202 MSQVRQSLQIPLIVNG----NVESYRDACDMHEQTGAAGVMAARGLLANPALFNSNYPDGKTTPL 262
            :..:..:|.||:|.||    :::.|.|..|..:.|.|:.||.||..:.||::|   ..:| ..||
Human   200 IKAIADTLSIPVIANGGSHDHIQQYSDIEDFRQATAASSVMVARAAMWNPSIF---LKEG-LRPL 260

  Fly   263 SCVQQWLDIASAAGDN-------LLFQCFHHHL-----TFMYSAQMKRDLRVQFNSLGSKEQVVD 315
            ..|.|.....:...||       .|.|.....|     ..:::||..|::...| .||:
Human   261 EEVMQKYIRYAVQYDNHYTNTKYCLCQMLREQLESPQGRLLHAAQSSREICEAF-GLGA------ 318

  Fly   316 FLKEHYNLEYSEVDPPSADYTDCTYTHFTPPKHARHIAAESDEQAWSSKSD 366
                .|.....|:|...|                 .::|::.||......|
Human   319 ----FYEETTQELDAQQA-----------------RLSAKTSEQTGEPAED 348

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10495	NP_609939.1	DUS_like_FMN	26..251	CDD:239200	63/247 (26%)
CG10495	NP_609939.1	Dus	28..321	CDD:279540	80/327 (24%)
DUS2	NP_001258691.1	Catalytic domain. /evidence=ECO:0000269\|PubMed:26429968	1..333		84/359 (23%)
		DUS_like_FMN	13..252	CDD:239200	63/246 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	330..349		5/36 (14%)
		Interaction with tRNA. /evidence=ECO:0000269\|PubMed:30605527	367..371
		DSRM	369..433	CDD:238007
		Interaction with tRNA. /evidence=ECO:0000269\|PubMed:30605527	420..424
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	438..493
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0042
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.810