DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Phlpp and LRIG2

DIOPT Version :9

Sequence 1:	NP_001260558.1	Gene:	Phlpp / 35178	FlyBaseID:	FBgn0032749	Length:	954	Species:	Drosophila melanogaster
Sequence 2:	NP_055628.1	Gene:	LRIG2 / 9860	HGNCID:	20889	Length:	1065	Species:	Homo sapiens

Alignment Length:	1085	Identity:	221/1085 - (20%)
Similarity:	370/1085 - (34%)	Gaps:	328/1085 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    73 LEVCENEMEVLDLSSLAQ-LETLKCSRNKLMELIING---TNLQTLVADHNYLHNISTTNTHPVP 133
            |:...|.:...::|..:| |:.:|.:.|:|.|:...|   :|:..|...||.:..|:.......|
Human    80 LDFSHNRLSNWNISLESQTLQEVKMNYNELTEIPYFGEPTSNITLLSLVHNIIPEINAQALQFYP 144

  Fly   134 LKLQRIDISHNNFSELPNWVGACASLTAINASHNRLNN--------------VAVLLRN------ 178
             .|:.:|:|.|..||:.........|..:|.|:||:..              |..|.||
Human   145 -ALESLDLSSNIISEIKTSSFPRMQLKYLNLSNNRITTLEAGCFDNLSSSLLVVKLNRNRMSMIP 208

  Fly   179 ---YRITELVSLDLAYNDLKQLDQFP-EGFSSIRSLQLQSNELPSLPDN-FFAVTHARLETLNVS 238
               :::..|..|:|..|.:|.::... :|..|:|||::|.|.:..|.|. ||.:.:  :|.|.:.
Human   209 PKIFKLPHLQFLELKRNRIKIVEGLTFQGLDSLRSLKMQRNGISKLKDGAFFGLNN--MEELELE 271

  Fly   239 CNKLSTLPRYEQNNHAALVNLSLAGN-HLNDSIFEPLHNAA-----KLRVLHLAYNRIGVLPAAC 297
            .|.|:.:      |...|..|.:... :::.:..|.:...|     :|..|.|:||::..|..:.
Human   272 HNNLTRV------NKGWLYGLRMLQQLYVSQNAIERISPDAWEFCQRLSELDLSYNQLTRLDESA 330

  Fly   298 VRNWPELEILVLSGNMLQQLPEEV-ATLGQLRVLRCCNNLLL-----CTPQLAKLAMLKVLDLSH 356
            ......||.|.|..|.:..:.:.| ..|..|:.|...||.:.     .:...|.|..|..|.|..
Human   331 FVGLSLLERLNLGDNRVTHIADGVFRFLSNLQTLDLRNNEISWAIEDASEAFAGLTSLTKLILQG 395

  Fly   357 NHLDRVNLLALVPSRNLKYLDLSGNLQLQVDEQQFKVCQSQSQRH------------------WS 403
            |.:..:...|.:...:|::|||:.|..:.:.|..|      ||.|                  |.
Human   396 NQIKSITKKAFIGLESLEHLDLNNNAIMSIQENAF------SQTHLKELILNTSSLLCDCHLKWL 454

  Fly   404 LVDVSGNN-------RAALP--------------------------TTKIRQVSAQRNQNKTSGP 435
            |..:..||       ..|.|                          .|....:.|.|..|.|...
Human   455 LQWLVDNNFQHSVNVSCAHPEWLAGQSILNVDLKDFVCDDFLKPQIRTHPETIIALRGMNVTLTC 519

  Fly   436 WTMGFAETPGSGDCRKLS--VYQLRAANY----------------------GGSDEALY------ 470
            ..:..:::|.|...||.|  :|.:...|:                      ..:||..|
Human   520 TAVSSSDSPMSTVWRKDSEILYDVDTENFVRYWQQAGEALEYTSILHLFNVNFTDEGKYQCIVTN 584

  Fly   471 -------------------------------GMFEALE--GRGRAAQEMS--------------- 487
                                           |....||  ..|..|.::|
Human   585 HFGSNYSQKAKLTVNEMPSFLKTPMDLTIRTGAMARLECAAEGHPAPQISWQKDGGTDFPAARER 649

  Fly   488 --HLVPD---LMKQEQMVKDSAVRDYMKFTLLAAQQQCGSVRSAALFHLTRTRAPSKVRPLKSKR 547
              |::|:   .......::|..:...|      ||...|.:.:.|  .||....||.:|||:.|.
Human   650 RMHVMPEDDVFFIANVKIEDMGIYSCM------AQNTAGGLSANA--SLTVLETPSFIRPLEDKT 706

  Fly   548 Y------VLRMASTGGLDAYLIRRTSQLRLTKPDVIQKDQIHSMPDPHVLELILSNDDEYLVVGN 606
            .      ||:..: ||..|      .:|..||.|           .|     :|..:..:....|
Human   707 VTRGETAVLQCIA-GGSPA------PRLNWTKDD-----------GP-----LLVTERHFFAAAN 748

  Fly   607 AQLWSVMD--IDRAAREIRKEENSL----------LAAKRLVDIAQSFAAAE-------SLSVIV 652
             ||..::|  ::.|.:......|:|          :.:....|.:||....|       .:.:||
Human   749 -QLLIIVDAGLEDAGKYTCIMSNTLGTERGHIYLNVISSPNCDSSQSSIGHEDDGWTTVGIVIIV 812

  Fly   653 VRFRHLGTD------VDHLIRELKQSVRKKPQPVSLPL-------SSGSVCK-RTCCDRSNACRH 703
            |....:||.      :.|:.|:.:.......:.::||.       |.|::.: :.....|.|..|
Human   813 VVCCVVGTSLIWVIVIYHMRRKNEDYSITNTEELNLPADIPSYLSSQGTLSEPQEGYSNSEAGSH 877

  Fly   704 RAIEQEPLAG---RSSPSGQSDRDLLAKDKDDEFVLAHAR------VLQEEQQLEMLDETESVSE 759
            :.: ..|..|   :.:..|...|.:.:...|:..:.:..|      .:.||   ::||:|.|
Human   878 QQL-MPPANGYIHKGTDGGTGTRVICSDCYDNANIYSRTREYCPYTYIAEE---DVLDQTLS--- 935

  Fly   760 SVLSEEQFKCWEYMLEQNTQLLFDKELNTISKSFTKQRTVPNAIMAATVLPERNDFTSNLMRTVT 824
            |::.:         :.:.|.|:...:..|..:|.     :|:|..      |.:.|.:|..|...
Human   936 SLMVQ---------MPKETYLVHPPQDTTALESL-----IPSANR------EPSAFPTNHERISE 980

  Fly   825 NKFIST--STPQLPQPI-TTSVPLGSYHQVKQAPPGHFGSALSFQQAHSYGYNLFDAKPRPKFHG 886
            .|..||  |...|.:|: ..:..||..|     ||      .|.|..|.          .|:.|.
Human   981 KKLPSTQMSGETLQRPVWNINRELGLPH-----PP------FSQQPVHE----------SPQLHQ 1024

  Fly   887 GTVKRSAGPN-SAYFGSLQRLMPYNFEYDFAVTQERERNILDEEE 930
            ........|: ||...|..||..:.|::      .|.|||.|..|
Human  1025 NEGLAGREPDCSASSMSCHRLQDHAFDF------SRTRNIQDGSE 1063

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Phlpp	NP_001260558.1	leucine-rich repeat	91..110	CDD:275380	6/21 (29%)
		LRR_8	109..169	CDD:290566	16/59 (27%)
		leucine-rich repeat	111..135	CDD:275380	5/23 (22%)
		leucine-rich repeat	136..158	CDD:275380	6/21 (29%)
		leucine-rich repeat	159..183	CDD:275380	9/46 (20%)
		leucine-rich repeat	184..209	CDD:275380	7/25 (28%)
		LRR_8	205..266	CDD:290566	17/62 (27%)
		leucine-rich repeat	210..230	CDD:275380	7/20 (35%)
		leucine-rich repeat	232..255	CDD:275380	5/22 (23%)
		LRR_RI	<256..410	CDD:238064	40/183 (22%)
		leucine-rich repeat	256..276	CDD:275380	3/20 (15%)
		LRR_8	279..359	CDD:290566	23/85 (27%)
		leucine-rich repeat	280..303	CDD:275380	6/22 (27%)
		leucine-rich repeat	304..348	CDD:275380	13/49 (27%)
		leucine-rich repeat	349..372	CDD:275380	5/22 (23%)
		PP2Cc	461..655	CDD:294085	51/299 (17%)
LRIG2	NP_055628.1	LRR_RI	<46..205	CDD:238064	31/125 (25%)
		LRR 1	76..97		3/16 (19%)
		LRR 2	98..119		6/20 (30%)
		leucine-rich repeat	99..121	CDD:275380	6/21 (29%)
		LRR_8	120..179	CDD:290566	16/59 (27%)
		LRR 3	121..142		5/20 (25%)
		leucine-rich repeat	122..145	CDD:275378	5/23 (22%)
		LRR 4	145..166		6/20 (30%)
		leucine-rich repeat	146..168	CDD:275380	6/21 (29%)
		LRR_8	168..251	CDD:290566	21/82 (26%)
		LRR 5	168..189		5/20 (25%)
		leucine-rich repeat	169..192	CDD:275380	5/22 (23%)
		LRR 6	193..214		4/20 (20%)
		leucine-rich repeat	194..216	CDD:275380	4/21 (19%)
		LRR 7	216..237		5/20 (25%)
		leucine-rich repeat	217..240	CDD:275380	6/22 (27%)
		LRR_8	240..299	CDD:290566	17/66 (26%)
		LRR 8	240..261		9/20 (45%)
		leucine-rich repeat	241..264	CDD:275380	9/22 (41%)
		LRR 9	264..285		6/28 (21%)
		leucine-rich repeat	265..288	CDD:275380	7/28 (25%)
		LRR_RI	266..492	CDD:238064	49/237 (21%)
		LRR 10	288..309		2/20 (10%)
		leucine-rich repeat	289..312	CDD:275380	2/22 (9%)
		LRR_8	312..371	CDD:290566	17/58 (29%)
		LRR 11	312..333		6/20 (30%)
		leucine-rich repeat	313..336	CDD:275380	6/22 (27%)
		LRR 12	336..357		6/20 (30%)
		leucine-rich repeat	337..360	CDD:275380	7/22 (32%)
		LRR_8	359..422	CDD:290566	16/62 (26%)
		LRR 13	360..382		4/21 (19%)
		leucine-rich repeat	361..385	CDD:275380	5/23 (22%)
		LRR 14	387..408		5/20 (25%)
		leucine-rich repeat	388..411	CDD:275380	5/22 (23%)
		LRR 15	411..432		7/26 (27%)
		leucine-rich repeat	412..434	CDD:275380	9/27 (33%)
		LRRCT	445..493	CDD:214507	6/47 (13%)
		Ig	502..598	CDD:299845	15/95 (16%)
		IG	504..598	CDD:214652	14/93 (15%)
		I-set	602..692	CDD:254352	15/97 (15%)
		Ig_1	619..693	CDD:143240	15/81 (19%)
		I-set	696..783	CDD:254352	24/110 (22%)
		Ig	714..783	CDD:299845	18/92 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	962..990		9/33 (27%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1003..1040		13/57 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910