DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Phlpp and Phlpp1

DIOPT Version :9

Sequence 1:	NP_001260558.1	Gene:	Phlpp / 35178	FlyBaseID:	FBgn0032749	Length:	954	Species:	Drosophila melanogaster
Sequence 2:	NP_598582.3	Gene:	Phlpp1 / 98432	MGIID:	2138327	Length:	1687	Species:	Mus musculus

Alignment Length:	804	Identity:	206/804 - (25%)
Similarity:	338/804 - (42%)	Gaps:	172/804 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    69 YLTQLEVCENEMEVLDLSSLAQLETLKCSRNKLMELIINGTNLQTLVADHNYLHNISTTNTHPVP 133
            ::|||::.:|::..||......:|.|.|.||:|:.|.:.|..|:.|.|..|.|..:   :.:|||
Mouse   788 HVTQLDLRDNKLGDLDAMIFNNIEVLHCERNQLVTLNVCGYFLKALYASSNELAQL---DVYPVP 849

  Fly   134 LKLQRIDISHNNFSELPNWVGACASLTAINASHNRLNNV-AVLLRNYRITELVSLDLAYNDLKQL 197
            ..|..:|:|.|....:|.||.....|..::..||::..: |.|..|..:.:|::   .:|.|.:|
Mouse   850 NYLSYMDVSRNCLESVPEWVCESRKLEVLDIGHNQICELPARLFCNSSLRKLLA---GHNRLARL 911

  Fly   198 DQFPEGF--SSIRSLQLQSNELPSLPDNFFAVTHARLETLNVSCNKLSTLP--RYEQNNHAALVN 258
               ||..  :|:..|.:|.|::..||.|......: |..||.|.|||.|||  ...:...:.|..
Mouse   912 ---PERLERTSVEVLDVQHNQITELPPNLLMKADS-LRFLNASANKLETLPPATLSEETSSILQE 972

  Fly   259 LSLAGNHLNDSIFEPLHNAAKLRVLHLAYNRIGVLPAACVRNWPELEILVLSGNMLQQLPEEVAT 323
            |.|..|.|.|.....|....:|::||:||||:...||:.:....|||.:.:|||.|:.:|..:..
Mouse   973 LYLTNNCLTDKCVPLLTGHPRLKILHMAYNRLQSFPASKMAKLEELEEIDISGNKLKAIPTTIMN 1037

  Fly   324 LGQLRVLRCCNNLLLCTPQLAKLAMLKVLDLSHNHLDRVNLLALVPSRNLKYLDLSGNLQLQVDE 388
            ..::..:...:|.:...|::.:|..:|.:|||.|.|..:.|...:|.: |:.|||:||.:|.:|.
Mouse  1038 CRRMHTVIAHSNCIEVFPEVMQLPEVKCVDLSCNELSEITLPENLPPK-LQELDLTGNPRLALDH 1101

  Fly   389 QQFKVCQSQSQRHWSLVDVSGNNRAALPTTKIRQVSAQRNQNKTSGP---WTMGFAETPGSGDCR 450
            :..::.               ||   :...||.|.||    ...||.   |:.|:.|  .||...
Mouse  1102 KSLELL---------------NN---IRCFKIDQPSA----GDASGAPAVWSHGYTE--ASGVKN 1142

  Fly   451 KLSVYQLRAANYGGSDEALYGMFEALEGRGRAAQEMSHLVPDLMKQ---EQMVKDSAVRDYMKFT 512
            ||.|..|...|:..:.|||||:|:     |....|:.:|:...|..   |::.|.....:||..|
Mouse  1143 KLCVAALSVNNFRDNREALYGVFD-----GDRNVEVPYLLQCTMSDILAEELQKTKNEEEYMVNT 1202

  Fly   513 LLAAQQQCGSV-----RSAALFHLTRTRAPSKVRPLK-SKRYVLRMASTGGLDAYLIRRTSQLRL 571
            .:..|::.|:.     .:|.|.|:       |..|:. ...:.|..|:.|.....|.|....|.|
Mouse  1203 FIVMQRKLGTAGQKLGGAAVLCHI-------KPDPVDLGGSFTLTSANVGKCQTVLCRNGKPLSL 1260

  Fly   572 TKPDVIQKDQ--------------------------------IHS--MPDPHVLELILSNDDEYL 602
            ::..::..::                                :|.  :|.|||..::|:..||:.
Mouse  1261 SRSYIMSCEEERKRIKQHKAIITEDGKVNGVTESTRILGYTFLHPSVVPRPHVQSVLLTPQDEFF 1325

  Fly   603 VVGNAQLWSVMDIDRAAREIRKEENSLLAAKRLVDIAQSFAAAESLSVIVVRFRHLGTDVDHLIR 667
            ::|:..||..:.||.|...:|...::|.|||:|..:|||:...:|:|.:||:
Mouse  1326 ILGSKGLWDSLSIDEAVEAVRNVPDALAAAKKLCTLAQSYGCHDSISAVVVQ------------- 1377

  Fly   668 ELKQSVRKKPQPVSLPLSSGSVCKRTCCDRSNA-------------CRHRAIEQEPLAGRSSPSG 719
                          |.::..|.|   ||:.|..             ..:..|:..|..|...||.
Mouse  1378 --------------LSVTEDSFC---CCELSAGGSMPPPSPGIFPPSVNMVIKDRPSDGLGVPSS 1425

  Fly   720 QSDRDLLAKDKDDEFVLAHARVLQEEQQLEMLDETESVS-----ESVLSEEQFKCWEYMLEQNTQ 779
            .|.   :|.:           :..|....||..|..|.:     ..||:|..   ..|..||...
Mouse  1426 SSG---MASE-----------ISSELSTSEMSSEVGSTASDEPPSGVLNESS---PAYPNEQRCM 1473

  Fly   780 L-------LFDKELN--TISKSFT 794
            |       .|.::|:  |.|.:|:
Mouse  1474 LHPVCLSNSFQRQLSSATFSSAFS 1497

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Phlpp	NP_001260558.1	leucine-rich repeat	91..110	CDD:275380	8/18 (44%)
		LRR_8	109..169	CDD:290566	18/59 (31%)
		leucine-rich repeat	111..135	CDD:275380	8/23 (35%)
		leucine-rich repeat	136..158	CDD:275380	7/21 (33%)
		leucine-rich repeat	159..183	CDD:275380	6/24 (25%)
		leucine-rich repeat	184..209	CDD:275380	7/26 (27%)
		LRR_8	205..266	CDD:290566	21/62 (34%)
		leucine-rich repeat	210..230	CDD:275380	6/19 (32%)
		leucine-rich repeat	232..255	CDD:275380	10/24 (42%)
		LRR_RI	<256..410	CDD:238064	43/153 (28%)
		leucine-rich repeat	256..276	CDD:275380	7/19 (37%)
		LRR_8	279..359	CDD:290566	25/79 (32%)
		leucine-rich repeat	280..303	CDD:275380	9/22 (41%)
		leucine-rich repeat	304..348	CDD:275380	10/43 (23%)
		leucine-rich repeat	349..372	CDD:275380	8/22 (36%)
		PP2Cc	461..655	CDD:294085	57/236 (24%)
Phlpp1	NP_598582.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..96
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	230..406
		PH_PHLPP-like	491..587	CDD:270131
		PH	511..592	CDD:278594
		LRR_RI	581..885	CDD:238064	32/99 (32%)
		LRR_8	594..659	CDD:290566
		LRR 1	594..615
		leucine-rich repeat	597..617	CDD:275380
		LRR 2	617..638
		leucine-rich repeat	618..648	CDD:275380
		LRR_8	647..726	CDD:290566
		LRR 3	648..669
		LRR 4	671..692
		leucine-rich repeat	672..694	CDD:275380
		LRR 5	694..715
		leucine-rich repeat	695..717	CDD:275380
		LRR 6	717..739
		leucine-rich repeat	718..740	CDD:275380
		LRR 7	740..760
		leucine-rich repeat	741..764	CDD:275380
		LRR 8	764..785
		LRR_RI	768..1030	CDD:238064	81/251 (32%)
		leucine-rich repeat	768..788	CDD:275380	206/804 (26%)
		LRR 9	788..809		6/20 (30%)
		leucine-rich repeat	789..809	CDD:275380	6/19 (32%)
		leucine-rich repeat	810..851	CDD:275380	16/43 (37%)
		LRR 10	829..850		7/23 (30%)
		LRR 11	851..872		7/20 (35%)
		leucine-rich repeat	852..874	CDD:275380	7/21 (33%)
		LRR 12	874..895		5/20 (25%)
		leucine-rich repeat	875..897	CDD:275380	6/21 (29%)
		LRR_8	896..954	CDD:290566	18/64 (28%)
		LRR 13	897..918		6/26 (23%)
		leucine-rich repeat	898..919	CDD:275380	6/26 (23%)
		LRR 14	919..940		7/20 (35%)
		leucine-rich repeat	920..943	CDD:275380	6/22 (27%)
		LRR 15	943..964		10/21 (48%)
		leucine-rich repeat	944..967	CDD:275380	10/22 (45%)
		LRR 16	969..989		6/19 (32%)
		LRR_8	970..1028	CDD:290566	22/57 (39%)
		leucine-rich repeat	970..993	CDD:275380	7/22 (32%)
		LRR 17	993..1014		9/20 (45%)
		leucine-rich repeat	994..1017	CDD:275380	9/22 (41%)
		LRR 18	1017..1038		8/20 (40%)
		LRR 19	1040..1061		2/20 (10%)
		LRR 20	1062..1083		7/20 (35%)
		leucine-rich repeat	1063..1085	CDD:275380	8/21 (38%)
		LRR 21	1085..1106		8/21 (38%)
		PP2Cc	1124..1376	CDD:214625	66/265 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1414..1465		14/67 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1604..1687
		PDZ-binding	1685..1687
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	71	1.000	Domainoid score	I9483
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S5072
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0003647
OrthoInspector	1	1.000	-	-		otm43529
orthoMCL	1	0.900	-	-		OOG6_102913
Panther	1	1.100	-	-	O	PTHR45752
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R9772
SonicParanoid	1	1.000	-	-		X32
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	13	12.750