DRSC/TRiP Functional Genomics Resources

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Protein Alignment Phlpp and LRRC4B

DIOPT Version :9

Sequence 1:NP_001260558.1 Gene:Phlpp / 35178 FlyBaseID:FBgn0032749 Length:954 Species:Drosophila melanogaster
Sequence 2:NP_001073926.1 Gene:LRRC4B / 94030 HGNCID:25042 Length:713 Species:Homo sapiens


Alignment Length:271 Identity:72/271 - (26%)
Similarity:122/271 - (45%) Gaps:55/271 - (20%)


- Green bases have known domain annotations that are detailed below.


  Fly   138 RIDISHNNFSELPNWVGACASLTAINASHNRL--NNVAVL----LRNYRITELVSLDLAYNDLKQ 196
            |:..:..:.:|:|      ||: .:|..:..|  |.:.|:    .::.|..|:  |.|:.|.:::
Human    69 RVICTRRDLAEVP------ASI-PVNTRYLNLQENGIQVIRTDTFKHLRHLEI--LQLSKNLVRK 124

  Fly   197 LD--QFPEGFSSIRSLQLQSNELPSLPDNFFAVTHARLETLNVSCNKLSTLPRYEQNNHAALVNL 259
            ::  .| .|..|:.:|:|..|.|.::|...|... ::|..|.:..|.:.::|.|..|...:|..|
Human   125 IEVGAF-NGLPSLNTLELFDNRLTTVPTQAFEYL-SKLRELWLRNNPIESIPSYAFNRVPSLRRL 187

  Fly   260 SLAG----NHLNDSIFEPLHNAAKLRVLHLAYNRIGVLP--AACVRNWPELEILVLSGNMLQQLP 318
            .|..    .:::::.||.|.|   ||.|:|....:..:|  .|.||    ||.|.||||.|    
Human   188 DLGELKRLEYISEAAFEGLVN---LRYLNLGMCNLKDIPNLTALVR----LEELELSGNRL---- 241

  Fly   319 EEVATLGQLRVLRCCNNLLLCTPQLA--------KLAMLKVLDLSHNHLDRVNLLAL-----VPS 370
             ::...|..:.|.....|.|...|:|        .|..|:.|:||||     ||::|     .|.
Human   242 -DLIRPGSFQGLTSLRKLWLMHAQVATIERNAFDDLKSLEELNLSHN-----NLMSLPHDLFTPL 300

  Fly   371 RNLKYLDLSGN 381
            ..|:.:.|:.|
Human   301 HRLERVHLNHN 311

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PhlppNP_001260558.1 leucine-rich repeat 91..110 CDD:275380
LRR_8 109..169 CDD:290566 6/30 (20%)
leucine-rich repeat 111..135 CDD:275380
leucine-rich repeat 136..158 CDD:275380 3/19 (16%)
leucine-rich repeat 159..183 CDD:275380 5/29 (17%)
leucine-rich repeat 184..209 CDD:275380 6/26 (23%)
LRR_8 205..266 CDD:290566 16/64 (25%)
leucine-rich repeat 210..230 CDD:275380 6/19 (32%)
leucine-rich repeat 232..255 CDD:275380 6/22 (27%)
LRR_RI <256..410 CDD:238064 43/145 (30%)
leucine-rich repeat 256..276 CDD:275380 6/23 (26%)
LRR_8 279..359 CDD:290566 29/89 (33%)
leucine-rich repeat 280..303 CDD:275380 8/24 (33%)
leucine-rich repeat 304..348 CDD:275380 15/51 (29%)
leucine-rich repeat 349..372 CDD:275380 10/27 (37%)
PP2Cc 461..655 CDD:294085
LRRC4BNP_001073926.1 LRRNT 57..90 CDD:214470 6/27 (22%)
LRR <76..297 CDD:227223 67/248 (27%)
LRR 1 87..108 4/20 (20%)
leucine-rich repeat 88..111 CDD:275380 3/22 (14%)
LRR 2 111..132 5/23 (22%)
leucine-rich repeat 112..135 CDD:275380 6/25 (24%)
LRR 3 135..156 7/20 (35%)
leucine-rich repeat 136..159 CDD:275380 6/23 (26%)
LRR 4 159..180 5/20 (25%)
leucine-rich repeat 160..183 CDD:275380 6/22 (27%)
LRR 5 183..205 4/21 (19%)
leucine-rich repeat 184..208 CDD:275380 6/23 (26%)
LRR 6 208..229 7/23 (30%)
leucine-rich repeat 209..230 CDD:275380 6/20 (30%)
LRR 7 230..251 10/29 (34%)
leucine-rich repeat 231..254 CDD:275380 10/27 (37%)
LRR 8 254..275 4/20 (20%)
leucine-rich repeat 255..278 CDD:275380 5/22 (23%)
LRR 9 278..299 9/25 (36%)
leucine-rich repeat 279..300 CDD:275380 9/25 (36%)
LRRCT 311..361 CDD:214507 1/1 (100%)
I-set 364..453 CDD:254352
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 497..551
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 694..713
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X32
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
11.000

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