DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Phlpp and CYR1

DIOPT Version :9

Sequence 1:	NP_001260558.1	Gene:	Phlpp / 35178	FlyBaseID:	FBgn0032749	Length:	954	Species:	Drosophila melanogaster
Sequence 2:	NP_012529.3	Gene:	CYR1 / 853452	SGDID:	S000003542	Length:	2026	Species:	Saccharomyces cerevisiae

Alignment Length:	1072	Identity:	228/1072 - (21%)
Similarity:	372/1072 - (34%)	Gaps:	332/1072 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    70 LTQLEVCENEMEVL-DLSSLAQLETLKCSRNKLMELIINGTNLQTLVADHNYLHNISTTNTHPVP 133
            |.::.:..|::..: |||.:..|.||....|::..:..|.:|||.|....|.:.|...|    :|
Yeast   957 LAKMNLSHNKLNFIGDLSEMTDLRTLNLRYNRISSIKTNASNLQNLFLTDNRISNFEDT----LP 1017

  Fly   134 LKLQRIDISHN--------------------NFSELPNWVG-ACASLTAINASHNRLNNVAVLLR 177
             ||:.::|..|                    |.::|.:..| ....|:.:.......||:..|.:
Yeast  1018 -KLRALEIQENPITSISFKDFYPKNMTSLTLNKAQLSSIPGELLTKLSFLEKLELNQNNLTRLPQ 1081

  Fly   178 NY-RITELVSLDLAYNDLKQLDQFPEGFSSIRSLQLQSNELPSLPDNFFAVTHARLETLNVSCNK 241
            .. ::|:||.|.:|.|.|:.:........|:|:|.|.||.:....|   .:.:..|.:||:|.|.
Yeast  1082 EISKLTKLVFLSVARNKLEYIPPELSQLKSLRTLDLHSNNIRDFVD---GMENLELTSLNISSNA 1143

  Fly   242 L--STLPR--YEQNNHAALVNLSL-----AGNHLNDSIFEPLHNA-AKLRVLHLAY--------- 287
            .  |:|..  |...::.:.::.||     |.|..:|::: ||.|. ..|:||:|:|
Yeast  1144 FGNSSLENSFYHNMSYGSKLSKSLMFFIAADNQFDDAMW-PLFNCFVNLKVLNLSYNNFSDVSHM 1207

  Fly   288 ------------NRIGVLPAACVRNWPELEILVLSGNMLQQLPEEVATLGQLRVLRCCNNLLLCT 340
                        |::..|....|..|..|:.|:|:.|.:..||.|::.|.||.|.....|.|
Yeast  1208 KLESITELYLSGNKLTTLSGDTVLKWSSLKTLMLNSNQMLSLPAELSNLSQLSVFDVGANQL--- 1269

  Fly   341 PQLAKLAMLKVLDLSHNHLD---RVNLLALVPSRNLKYLDLSGNLQLQVDE-------------- 388
                      ..::|:.|.|   |.|       :.||||:.|||.:.::..
Yeast  1270 ----------KYNISNYHYDWNWRNN-------KELKYLNFSGNRRFEIKSFISHDIDADLSDLT 1317

  Fly   389 --QQFKVCQSQSQRHWSLVDVSGNNRAALPTTKIRQVSAQRNQNKTS---GPWTMGFAETPGSGD 448
              .|.||.        .|:||:      |.|||:...:.......|:   .....|.|:|.|..|
Yeast  1318 VLPQLKVL--------GLMDVT------LNTTKVPDENVNFRLRTTASIINGMRYGVADTLGQRD 1368

  Fly   449 ---CRKLSVYQLRAANYGGSDEALYGMFEALEGRGRAAQEMSHLVPD-----LMKQEQMVKDSA- 504
               .|.::..:.|    |..||.|..:.::..........:|.:|.|     |::|.:...|..
Yeast  1369 YVSSRDVTFERFR----GNDDECLLCLHDSKNQNADYGHNISRIVRDIYDKILIRQLERYGDETD 1429

  Fly   505 --VRDYMKFTLLAAQQQ--------------------------CGSV---RSAALF--------- 529
              ::..::|:.|...::                          |.:|   |...||
Yeast  1430 DNIKTALRFSFLQLNKEINGMLNSVDNGADVANLSYADLLSGACSTVIYIRGKKLFAANLGDCMA 1494

  Fly   530 ----------HLTRTRAPSKVRPLKSKRYVLRMASTGGLDAYLIRRTSQLRLTKPDVIQK----- 579
                      .||:...|:|....:..|......:.|.||..:            ||.:.
Yeast  1495 ILSKNNGDYQTLTKQHLPTKREEYERIRISGGYVNNGKLDGVV------------DVSRAVGFFD 1547

  Fly   580 --DQIHSMPDPHVLELILSNDDEYLVVGNAQLWSVMDIDRAAREIRKEENS--LLAAKRLVDIAQ 640
              ..||:.||..|  :.|:..||.|:|...:||..||:|... :|.:|.::  |.||..|.|.|.
Yeast  1548 LLPHIHASPDISV--VTLTKADEMLIVATHKLWEYMDVDTVC-DIARENSTDPLRAAAELKDHAM 1609

  Fly   641 SFAAAESLSVIVVRFRHLGTDVDHLIRELKQSVRKKPQPVSLPLSSGSVCKRTCCDRSNACRHRA 705
            ::...|:::::.:.          |...::|..|       ..|:..|:..|.........|...
Yeast  1610 AYGCTENITILCLA----------LYENIQQQNR-------FTLNKNSLMTRRSTFEDTTLRRLQ 1657

  Fly   706 IEQEPLAGRSSPSGQSDRDLLAKDKDDEFVLAHARVLQEEQQLEMLDETESVSESVLSEEQFKCW 770
            .|..|      |:|                           .|.|: .|:..|.:.|       |
Yeast  1658 PEISP------PTG---------------------------NLAMV-FTDIKSSTFL-------W 1681

  Fly   771 EYMLEQNTQLLFDKELNTISKSFT-------------KQRTVPNAIMAATVLPERNDFTSNL--M 820
            |         ||...:.|..|:..             :.:|..:|.|.|...|     ||.|  .
Yeast  1682 E---------LFPNAMRTAIKTHNDIMRRQLRIYGGYEVKTEGDAFMVAFPTP-----TSGLTWC 1732

  Fly   821 RTVTNKFISTSTPQLPQPITTSVPLGSYHQVKQAPPGHFGSALSFQQAHSYGY---NLFDAKPRP 882
            .:|..|.:..   |.|:.| |||..|.  ||...........||.:....:|.   .|.....|.
Yeast  1733 LSVQLKLLDA---QWPEEI-TSVQDGC--QVTDRNGNIIYQGLSVRMGIHWGCPVPELDLVTQRM 1791

  Fly   883 KFHGGTVKRSA-----------GPNSAYFGSLQRLMPYN--------------FEYDFAVTQERE 922
            .:.|..|.::|           ..:|.::....::|.|:              .|.......|||
Yeast  1792 DYLGPMVNKAARVQGVADGGQIAMSSDFYSEFNKIMKYHERVVKGKESLKEVYGEEIIGEVLERE 1856

  Fly   923 RNILDEEEHDDDDFNEHESRMRKYWGVATTEL 954
            ..:|:.......||.||     |..|:.|.||
Yeast  1857 IAMLESIGWAFFDFGEH-----KLKGLETKEL 1883

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Phlpp	NP_001260558.1	leucine-rich repeat	91..110	CDD:275380	5/18 (28%)
		LRR_8	109..169	CDD:290566	16/80 (20%)
		leucine-rich repeat	111..135	CDD:275380	7/23 (30%)
		leucine-rich repeat	136..158	CDD:275380	6/42 (14%)
		leucine-rich repeat	159..183	CDD:275380	4/24 (17%)
		leucine-rich repeat	184..209	CDD:275380	7/24 (29%)
		LRR_8	205..266	CDD:290566	19/69 (28%)
		leucine-rich repeat	210..230	CDD:275380	5/19 (26%)
		leucine-rich repeat	232..255	CDD:275380	8/26 (31%)
		LRR_RI	<256..410	CDD:238064	48/199 (24%)
		leucine-rich repeat	256..276	CDD:275380	7/24 (29%)
		LRR_8	279..359	CDD:290566	23/100 (23%)
		leucine-rich repeat	280..303	CDD:275380	9/43 (21%)
		leucine-rich repeat	304..348	CDD:275380	13/43 (30%)
		leucine-rich repeat	349..372	CDD:275380	5/25 (20%)
		PP2Cc	461..655	CDD:294085	51/258 (20%)
CYR1	NP_012529.3	Ad_cyc_g-alpha	368..418	CDD:369912
		RA_PHLPP_like	678..776	CDD:340473
		PLN00113	792..>1273	CDD:215061	81/337 (24%)
		leucine-rich repeat	796..817	CDD:275380
		leucine-rich repeat	818..839	CDD:275380
		leucine-rich repeat	840..864	CDD:275380
		leucine-rich repeat	865..887	CDD:275380
		leucine-rich repeat	888..910	CDD:275380
		leucine-rich repeat	911..933	CDD:275380
		leucine-rich repeat	934..956	CDD:275380
		leucine-rich repeat	957..978	CDD:275380	5/20 (25%)
		leucine-rich repeat	979..1018	CDD:275380	13/43 (30%)
		leucine-rich repeat	1019..1041	CDD:275380	3/21 (14%)
		leucine-rich repeat	1042..1065	CDD:275380	4/22 (18%)
		leucine-rich repeat	1066..1088	CDD:275380	3/21 (14%)
		leucine-rich repeat	1089..1111	CDD:275380	6/21 (29%)
		leucine-rich repeat	1167..1187	CDD:275380	6/20 (30%)
		leucine-rich repeat	1191..1211	CDD:275380	5/19 (26%)
		leucine-rich repeat	1236..1258	CDD:275380	8/21 (38%)
		leucine-rich repeat	1259..1287	CDD:275380	9/47 (19%)
		PP2C	1374..1617	CDD:395385	52/261 (20%)
		CYCc	1613..1825	CDD:214485	51/289 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157345010
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_102913
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R9772
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.670