DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Phlpp and AT1G72860

DIOPT Version :9

Sequence 1:	NP_001260558.1	Gene:	Phlpp / 35178	FlyBaseID:	FBgn0032749	Length:	954	Species:	Drosophila melanogaster
Sequence 2:	NP_001322142.1	Gene:	AT1G72860 / 843617	AraportID:	AT1G72860	Length:	1306	Species:	Arabidopsis thaliana

Alignment Length:	841	Identity:	179/841 - (21%)
Similarity:	303/841 - (36%)	Gaps:	210/841 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    39 QAATFGQTSP----QKLSLKGSQLGGSILIGNYNY------LTQLE-----VC-------ENEME 81
            |.|..|...|    :|||::.|.|...:.:....|      :|.|:     :|       |:.||
plant   356 QLAFKGALPPSELYEKLSIRASWLAQGLPVAIEAYGLFFRRMTSLKEWDDALCRFIEAPDESVME 420

  Fly    82 VLDLSSLAQLETLKCSRNKLMEL--IINGTNLQ--TLVADHNYLHNISTTNTHPVPLKL----QR 138
            :|.:|.....||   .:|..:.:  :.||..|:  |.:.|...|...       :.||:    ..
plant   421 ILKISYDGLEET---DKNVFLHVACLFNGEPLRRATTLLDDGVLQGC-------LGLKILAEKSL 475

  Fly   139 IDISHNNFSELPNWVGACASLTAINASHNRLNNVAVLLRNYRITELV------------------ 185
            |:|:.:.:.::.|.|...|.......|..|.:...||...|.|.||:
plant   476 IEITASGYIKMHNLVDQTARAIVNQESMQRRHGRGVLWNPYEIYELLKRNTTSEPTNCMALHMCD 540

  Fly   186 ---SLDL----AYNDLKQLDQFPEGFSSIRSLQLQSNELPSLPDNFFAVTHARLETLNVSCNKLS 243
               :|.|    ||:|..:..:..:..:.|:|..|.|.:..:|       ..:||..|:.....|:
plant   541 MVYALHLGGYTAYHDTLKFLKIYKHSNHIKSKLLFSGDDTNL-------LSSRLRLLHWDAFPLT 598

  Fly   244 TLP-RYEQNNHAALVNLSLAGNHLNDSIFEPLHNAAKLRVLHLA-YNRIGVLPAACVRNWPELEI 306
            |.| |::..:   ||.:.|..::|. |.::.......||.|.|: ...:..||...:.  ..||.
plant   599 TFPCRFQPQD---LVEIILHRSNLT-SFWKETVGMPNLRRLDLSDSENLEQLPDLSMA--VNLEE 657

  Fly   307 LVLSG-NMLQQLPEEVATLGQLRVLRCCNNLLLCTPQLAKLAMLKVLDLSHNHLDRVNLLAL--- 367
            |:..| ..|:::||.::.|.:|..|    ::..| .:||....::.|:.|...      :||
plant   658 LITQGCKRLKKIPESISYLTRLTTL----DVSYC-EELASYITIRELNRSGRQ------IALYFS 711

  Fly   368 ---VPSRNLKYLDLSGNLQLQ-------VDEQQFKVCQSQSQRHWSLVDVSGNNRAALPTTKIRQ 422
               |.:|::..|.:.||:.:|       ||...|...|....:      ::...:...|....::
plant   712 GKEVETRSIANLSIGGNIHIQMFWLDGNVDHLSFTTEQQGPDK------LTKKEKQQAPGELTKR 770

  Fly   423 VSAQRNQNKTSGPWTMGFAETPGSGDCRKLSVY-------------QLRAANYGGSDEALYGMFE 474
            ...|..:.||.   ..||......|  ||:...             ||...|.           :
plant   771 EQQQEPRKKTI---LCGFGSLMRKG--RKVKATSEFLDHEWMMQRDQLAPDNQ-----------Q 819

  Fly   475 ALEGRGRAAQEMSHLVPDLMKQEQMV----KDSAVRDYMKFTLL----------AAQQQCGS--- 522
            |||...|..|.:..| |:...||.:.    |......:..||.:          .|...|.|
plant   820 ALEFSTRTRQALQFL-PEFHGQESVKKAQGKSQPTSKFHGFTSVDISRFRYSSDGASFLCFSLSM 883

  Fly   523 ---VRSAALFHLTRTRAPSKVRPLKSKRYVLRMASTGGLDAYLIRRT-SQL-RLTKPDVIQKDQI 582
               |:...|.:|.....|..|..||    .|......|.|...:..| :|| ||.........::
plant   884 FPCVKELILINLNIKVIPDDVCGLK----FLEKLDWSGNDFETLPETMNQLPRLKYASFRNCCRL 944

  Fly   583 HSMPDPHVLELI-LSNDDEYLVVGNAQLWSVMDIDRAAREIRKEE------NSLLAAKRLVDIAQ 640
            .::|....||.| ||        |...|.|::::..|.::..:.:      :...:.:.::|..:
plant   945 KALPALVQLETIKLS--------GCINLQSLLELSYAEQDCGRFQWLELWVDGCKSIRSILDQLR 1001

  Fly   641 SFAAAESLSVIVVRFRHLGTDVDHL--IRELKQSVRKKPQPV-SLPLSSGSVCKRTCCDRSNACR 702
            .|.....|.:....|..|.:.::.|  :|.|..:..||.:.: .|||...|:....|
plant  1002 HFIKLSYLDLSSHEFEKLPSSIEVLSSLRTLCLNKCKKLKSIEGLPLCLKSLYAHGC-------- 1058

  Fly   703 HRAIEQEPLAGRSSPSGQSDRDLLAKDKDDEFVLAHARVLQEEQQL--EMLDETESVSESV 761
                  |.|...|.|...|.:.|         .|:|...|:.::.|  :.|:|.|:..||:
plant  1059 ------EILETVSLPLNHSVKHL---------DLSHCFGLKRDEHLIAQFLNEGENEEESL 1104

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Phlpp	NP_001260558.1	leucine-rich repeat	91..110	CDD:275380	5/20 (25%)
		LRR_8	109..169	CDD:290566	12/65 (18%)
		leucine-rich repeat	111..135	CDD:275380	4/25 (16%)
		leucine-rich repeat	136..158	CDD:275380	4/25 (16%)
		leucine-rich repeat	159..183	CDD:275380	6/23 (26%)
		leucine-rich repeat	184..209	CDD:275380	7/49 (14%)
		LRR_8	205..266	CDD:290566	15/61 (25%)
		leucine-rich repeat	210..230	CDD:275380	3/19 (16%)
		leucine-rich repeat	232..255	CDD:275380	6/23 (26%)
		LRR_RI	<256..410	CDD:238064	38/168 (23%)
		leucine-rich repeat	256..276	CDD:275380	5/19 (26%)
		LRR_8	279..359	CDD:290566	21/81 (26%)
		leucine-rich repeat	280..303	CDD:275380	6/23 (26%)
		leucine-rich repeat	304..348	CDD:275380	13/44 (30%)
		leucine-rich repeat	349..372	CDD:275380	5/28 (18%)
		PP2Cc	461..655	CDD:294085	44/222 (20%)
AT1G72860	NP_001322142.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X32
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.000