DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Phlpp and RLP11

DIOPT Version :9

Sequence 1:	NP_001260558.1	Gene:	Phlpp / 35178	FlyBaseID:	FBgn0032749	Length:	954	Species:	Drosophila melanogaster
Sequence 2:	NP_001321997.1	Gene:	RLP11 / 843480	AraportID:	AT1G71390	Length:	789	Species:	Arabidopsis thaliana

Alignment Length:	769	Identity:	168/769 - (21%)
Similarity:	262/769 - (34%)	Gaps:	230/769 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    51 LSLKGSQLGGSI--LIGNYNYLTQLEVCENEM--EV-LDLSSLAQLETLKCSRNKL--------- 101
            |.|.|..|.|.|  .:||.:.|..||:..|.:  |: ..:.:|.||..|....|.|
plant   112 LDLSGCNLHGEIPSSLGNLSRLENLELSSNRLVGEIPYSIGNLKQLRNLSLGDNDLIGEIPSSLG 176

  Fly   102 -MELII------------------NGTNLQTLVADHNYLHN---ISTTNTHPVPLKLQRIDISHN 144
             :.|::                  |...|:.:..|.|.|..   ||.||.    .||....|..|
plant   177 NLSLLLDLDLWNNSLVGEVPASIGNLNELRVMSLDRNSLSGSIPISFTNL----TKLSEFRIFFN 237

  Fly   145 NFSELPNWVGACASLTAINASHNRLNNVAVLLRNYRITELVSLDLAYNDLKQLDQFPEGFSSIRS 209
            ||:.||         :.::..||                ||:.|::.|...  ..||:...||.|
plant   238 NFTSLP---------SDLSGFHN----------------LVTFDISANSFS--GHFPKFLFSIPS 275

  Fly   210 LQLQSNELPSLPDNFFAVTHARLETLNVSCNKLSTLPRYEQNNHAALVNLSLAGNHLNDSIFEPL 274
            |     ...|:..|.|:   ..:|..|:|             :.:.|.||.|..|.|:.||.|.:
plant   276 L-----AWVSMDRNQFS---GPIEFANIS-------------SSSKLQNLILTRNKLDGSIPESI 319

  Fly   275 HNAAKLRVLHLAYNRI-GVLPAACVRNWPELEILVLSGNMLQQLPEEVAT-LGQLRVLRCCNNLL 337
            .....|.:|.:|:|.| |.:|    |:..:|..|.:.|....:|..||.: |.:|......:|..
plant   320 SKFLNLVLLDVAHNNISGPVP----RSMSKLVSLRIFGFSNNKLEGEVPSWLWRLSSTMLSHNSF 380

  Fly   338 LCTPQL-AKLAMLKVLDLSHNHLDRVNLLALVPSRNLKYLDLSGNLQLQVDEQQFKVCQSQSQRH 401
            ....:: :|..|::|||||.|.......:.:...:.|.:||||.||        |........|:
plant   381 SSFEKIYSKETMIQVLDLSFNSFRGTFPVWICKLKGLHFLDLSNNL--------FNGSIPLCLRN 437

  Fly   402 WSL--------------------------VDVSGNN------RAALPTTKIRQVSAQRNQNKTSG 434
            ::|                          :|||||.      ::.:....:..|:.:.|:.|.:.
plant   438 FNLTGLILGNNKFSGTLPDIFANNTNLQSLDVSGNQLEGKFPKSLINCKGLHFVNVESNKIKDTF 502

  Fly   435 P-WTMGFAETPGSGDCRKLSVYQLRAANYGGSDEALYGMFEALEGRGRAAQEMSH------LVPD 492
            | |.         |....|.|..||:.::.|   .||....::..:|....::||      |.|:
plant   503 PSWL---------GSLPSLQVLILRSNDFYG---PLYHPSMSIGFQGLRIIDISHNGFSGVLPPN 555

  Fly   493 LMKQ-EQMV-----KDSAVRDYMKFTLLAAQQQCGSVRSAALFHLTRTRAPSKVRPLKSKR-YVL 550
            .... .:|:     ....:.|...::|:....:  .|.........|.|...:.......| |..
plant   556 FFSSWREMITLVHGSYEYIEDIQNYSLIYRSME--MVNKGVEMSFERIRQDFRAIDFSENRIYGE 618

  Fly   551 RMASTGGLDAYLIRRTSQLRLTKPDVIQKDQIHSMPDPHVLELILSNDDEYLVVGNAQLWSVMDI 615
            ...|.|.|:        :|||                     |.||        |||   ...||
plant   619 IPESIGCLE--------ELRL---------------------LNLS--------GNA---FTSDI 643

  Fly   616 DRAAREIRKEENSLLAAKRLV-DIAQSFAAAESLSVIVVRFRHLGTDVDHLIRELKQSVRKKPQP 679
            .|....:.|.|...|:..:|. .|.|.......||  .:.|.|                    ..
plant   644 PRVWENLTKLETLDLSRNKLSGQIPQDLGKLSFLS--YMNFSH--------------------NR 686

  Fly   680 VSLPLSSGSVCKRTCCDRSNACRHRAIEQEPLAGRS---SPSGQSDRDLLAKDK 730
            :..|:..|:..:|..|. |....||....|.:...:   :|:.|...|||.:::
plant   687 LQGPVPRGTQFQRQRCS-SFLDNHRLYGLEDICEETHVPNPTSQPSEDLLDEEE 739

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Phlpp	NP_001260558.1	leucine-rich repeat	91..110	CDD:275380	6/46 (13%)
		LRR_8	109..169	CDD:290566	18/62 (29%)
		leucine-rich repeat	111..135	CDD:275380	8/26 (31%)
		leucine-rich repeat	136..158	CDD:275380	7/21 (33%)
		leucine-rich repeat	159..183	CDD:275380	2/23 (9%)
		leucine-rich repeat	184..209	CDD:275380	8/24 (33%)
		LRR_8	205..266	CDD:290566	15/60 (25%)
		leucine-rich repeat	210..230	CDD:275380	4/19 (21%)
		leucine-rich repeat	232..255	CDD:275380	3/22 (14%)
		LRR_RI	<256..410	CDD:238064	47/182 (26%)
		leucine-rich repeat	256..276	CDD:275380	9/19 (47%)
		LRR_8	279..359	CDD:290566	25/82 (30%)
		leucine-rich repeat	280..303	CDD:275380	8/23 (35%)
		leucine-rich repeat	304..348	CDD:275380	10/45 (22%)
		leucine-rich repeat	349..372	CDD:275380	6/22 (27%)
		PP2Cc	461..655	CDD:294085	39/207 (19%)
RLP11	NP_001321997.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D172467at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010