DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Phlpp and AT1G27170

DIOPT Version :9

Sequence 1:	NP_001260558.1	Gene:	Phlpp / 35178	FlyBaseID:	FBgn0032749	Length:	954	Species:	Drosophila melanogaster
Sequence 2:	NP_001154372.1	Gene:	AT1G27170 / 839606	AraportID:	AT1G27170	Length:	1384	Species:	Arabidopsis thaliana

Alignment Length:	811	Identity:	168/811 - (20%)
Similarity:	274/811 - (33%)	Gaps:	260/811 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    64 IGNYNYLTQLEV--CENEMEVL-DLSSLAQLETL---KCS-----------RNKLMELIINGTNL 111
            :||...|..|:.  |....|.| |:|.|..||.|   .||           ...|.||:::||.:
plant   713 VGNLRKLIHLDFRRCSKLSEFLVDVSGLKLLEKLFLSGCSDLSVLPENIGAMTSLKELLLDGTAI 777

  Fly   112 QTLVADHNYLHNISTTN-----THPVPL------KLQRIDISHNNFSELPNWVG----------- 154
            :.|....|.|.|:...:     ...:||      .|:::.:.......||:.:|
plant   778 KNLPESINRLQNLEILSLRGCKIQELPLCIGTLKSLEKLYLDDTALKNLPSSIGDLKNLQDLHLV 842

  Fly   155 ACASLTAINASHNRLNNVAVLLRNYRITELVSL---------DLAYNDLKQLDQFPEG---FSSI 207
            .|.||:.|..|.|.|.::..|..|....|.:.|         |.:..|.|.|.|.|..   .:|:
plant   843 RCTSLSKIPDSINELKSLKKLFINGSAVEELPLKPSSLPSLYDFSAGDCKFLKQVPSSIGRLNSL 907

  Fly   208 RSLQLQSNELPSLPDNFFAVTHAR-LETLNVSCNKLSTLPRYEQNNHAALVNLSLAGNHLND--S 269
            ..|||.|..:.:||:...|:...| ||..|  |..|..||: ...:...|.:|:|.|:::.:  .
plant   908 LQLQLSSTPIEALPEEIGALHFIRELELRN--CKFLKFLPK-SIGDMDTLYSLNLEGSNIEELPE 969

  Fly   270 IFEPLHNAAKLRVLHLAYNRIGVLPAACVRNWPELEILVLSGNMLQQLPEEVATLGQLRVLRCCN 334
            .|..|....:||:            :.|              .||::|||....|..|..|....
plant   970 EFGKLEKLVELRM------------SNC--------------KMLKRLPESFGDLKSLHRLYMKE 1008

  Fly   335 NLLLCTPQ-LAKLAMLKVLDLSHNHLDRVNLLALVP--SRNLKYLDLSGNLQLQVDEQQFKVCQS 396
            .|:...|: ...|:.|.||::....|.|:: .:.||  |...:::::..:....:..::...|.
plant  1009 TLVSELPESFGNLSNLMVLEMLKKPLFRIS-ESNVPGTSEEPRFVEVPNSFSKLLKLEELDACS- 1071

  Fly   397 QSQRHWSLVDVSGNNRAALPTTKIRQVSAQRNQNKTSGPWTMGFAETPGSGDCRKLSVYQLRAAN 461
                 |.   :||.    :|                              .|..|||.  |...|
plant  1072 -----WR---ISGK----IP------------------------------DDLEKLSC--LMKLN 1092

  Fly   462 YGGS-----DEALYGMFEALEGRGRAAQEMSHLVPDLMKQEQM-----VKDSAVRDYMKFTLLAA 516
            .|.:     ..:|..:....|...|..:|:..|.|...|.||:     ....:|.|..:.|:|..
plant  1093 LGNNYFHSLPSSLVKLSNLQELSLRDCRELKRLPPLPCKLEQLNLANCFSLESVSDLSELTILTD 1157

  Fly   517 QQ--QCGSVRS-AALFHLTRTRAPSKVRPLKSKRYVLRMASTGGLDAYLI---RRTSQLRLTK-- 573
            ..  .|..|.. ..|.|||..:               |:..||....|.:   :|.|:..|..
plant  1158 LNLTNCAKVVDIPGLEHLTALK---------------RLYMTGCNSNYSLAVKKRLSKASLKMMR 1207

  Fly   574 ---------PDVIQKDQIHSMPDPH------VLELIL-----SNDDEYLVVGNAQLWSVMDIDRA 618
                     ||...:..:.....|:      ::.:::     :.||:|      ||..||::...
plant  1208 NLSLPGNRVPDWFSQGPVTFSAQPNRELRGVIIAVVVALNDETEDDDY------QLPDVMEVQAQ 1266

  Fly   619 AREI--RKEENSLLAAKRLVDIAQSFAAAESLSVIVVRFRHLG----TDVDH-----------LI 666
            ..::  .|..|:|                           ||.    |:.|.           |:
plant  1267 IHKLDHHKCTNTL---------------------------HLSGVPRTNNDQLHICRYSAFHPLV 1304

  Fly   667 RELK-----QSVRKKPQPVSLPLSSGSVCKRTCCDRSNACRHRAIE-QEPLAGRSSPSGQSDRDL 725
            ..||     |.:::.|     |:..|...|....       |...| .:.|.||.:...::.:.:
plant  1305 TMLKDGYTIQVIKRNP-----PIKQGVELKMHGI-------HLVYEGDDDLEGRENTLPETQQTV 1357

  Fly   726 LAKDKDDEFVLAHARVLQEEQQLEMLDETES 756
            ..|       ||:.....||::.|.:.|:||
plant  1358 SQK-------LANFFSSFEEEEGETISESES 1381

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Phlpp	NP_001260558.1	leucine-rich repeat	91..110	CDD:275380	9/32 (28%)
		LRR_8	109..169	CDD:290566	17/81 (21%)
		leucine-rich repeat	111..135	CDD:275380	6/34 (18%)
		leucine-rich repeat	136..158	CDD:275380	5/32 (16%)
		leucine-rich repeat	159..183	CDD:275380	7/23 (30%)
		leucine-rich repeat	184..209	CDD:275380	8/36 (22%)
		LRR_8	205..266	CDD:290566	20/61 (33%)
		leucine-rich repeat	210..230	CDD:275380	7/19 (37%)
		leucine-rich repeat	232..255	CDD:275380	7/22 (32%)
		LRR_RI	<256..410	CDD:238064	31/158 (20%)
		leucine-rich repeat	256..276	CDD:275380	6/21 (29%)
		LRR_8	279..359	CDD:290566	17/80 (21%)
		leucine-rich repeat	280..303	CDD:275380	3/22 (14%)
		leucine-rich repeat	304..348	CDD:275380	11/44 (25%)
		leucine-rich repeat	349..372	CDD:275380	8/24 (33%)
		PP2Cc	461..655	CDD:294085	41/233 (18%)
AT1G27170	NP_001154372.1	TIR	17..181	CDD:279864
		AAA_16	189..307	CDD:289934
		NB-ARC	206..464	CDD:279299
		leucine-rich repeat	604..623	CDD:275380
		leucine-rich repeat	625..646	CDD:275380
		leucine-rich repeat	647..671	CDD:275380
		leucine-rich repeat	672..694	CDD:275380
		leucine-rich repeat	695..718	CDD:275380	2/4 (50%)
		leucine-rich repeat	743..766	CDD:275380	5/22 (23%)
		leucine-rich repeat	767..789	CDD:275380	8/21 (38%)
		LRR_4	788..828	CDD:289563	5/39 (13%)
		leucine-rich repeat	790..812	CDD:275380	2/21 (10%)
		leucine-rich repeat	813..835	CDD:275380	4/21 (19%)
		leucine-rich repeat	836..882	CDD:275380	11/45 (24%)
		leucine-rich repeat	931..953	CDD:275380	8/24 (33%)
		leucine-rich repeat	954..976	CDD:275380	6/21 (29%)
		leucine-rich repeat	977..1000	CDD:275380	9/48 (19%)
		leucine-rich repeat	1001..1023	CDD:275380	5/21 (24%)
		leucine-rich repeat	1024..1063	CDD:275380	8/39 (21%)
		leucine-rich repeat	1064..1087	CDD:275380	8/65 (12%)
		LRR_RI	<1079..>1181	CDD:238064	27/148 (18%)
		leucine-rich repeat	1088..1110	CDD:275380	4/21 (19%)
		leucine-rich repeat	1155..1174	CDD:275381	4/18 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X32
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.000