DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Phlpp and RLP1

DIOPT Version :9

Sequence 1:	NP_001260558.1	Gene:	Phlpp / 35178	FlyBaseID:	FBgn0032749	Length:	954	Species:	Drosophila melanogaster
Sequence 2:	NP_001154318.1	Gene:	RLP1 / 837251	AraportID:	AT1G07390	Length:	1083	Species:	Arabidopsis thaliana

Alignment Length:	836	Identity:	182/836 - (21%)
Similarity:	308/836 - (36%)	Gaps:	250/836 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    44 GQTSPQKLSLKGSQLGGSILIGNYNYLTQLEVCE-NEMEVLDLS-------------SLAQLETL 94
            |...||:||...:....::...::::|:...:.: .::||||||             |.|:|:||
plant   149 GVFPPQELSNMTNLRVLNLKDNSFSFLSSQGLTDFRDLEVLDLSFNGVNDSEASHSLSTAKLKTL 213

  Fly    95 KCSRNKLMELI-ING----TNLQTLVADHNYLHNISTTNTHPV-PLK-LQRIDISHNNFSELPN- 151
            ..:.|.|.:.. :.|    ..||.|....|..::  |.:||.: .|| ||.:|:|.|.|:.|.:
plant   214 DLNFNPLSDFSQLKGLESLQELQVLKLRGNKFNH--TLSTHVLKDLKMLQELDLSDNGFTNLDHG 276

  Fly   152 ------------------------WVGACASLTAINASHNRLNNVAV----LLRNYRITELVSLD 188
                                    |:|...|. .::.:|::  :|.|    .|.....|.|..||
plant   277 RDVDESRSEKRFDFREVVQKVETLWIGLRLSF-QMSITHHK--SVTVGGNGFLGLEIPTSLQVLD 338

  Fly   189 LAYNDLKQLDQFPEGFSSI------RSLQLQSNELPSLPDNFFAVTHARLETLNVSCNKLS-TLP 246
            ...|   ||....||:..|      |.|.|.||.|.|||.....:||  |.||::|.|:|: .|.
plant   339 FKRN---QLSLTHEGYLGICRLMKLRELDLSSNALTSLPYCLGNLTH--LRTLDLSNNQLNGNLS 398

  Fly   247 RYEQNNHAALVNLSLAGNHLNDS-IFEPLHNAAKLRV---------------------------- 282
            .:.....:.|..|||..|:.:.| :|..|.|..:|.|
plant   399 SFVSGLPSVLEYLSLLDNNFDGSFLFNSLVNQTRLTVFKLSSKVGVIQVQTESSWAPLFQLKMLY 463

  Fly   283 ----------------------LHLAYNRI-GVLPAACVRNWPELEILVLSGNMLQQLPEEVATL 324
                                  :.|::|:: |..|...|:|...|:.::||||.|.:|...:...
plant   464 LSNCSLGSTMLGFLVHQRDLCFVDLSHNKLTGTFPTWLVKNNTRLQTILLSGNSLTKLQLPILVH 528

  Fly   325 GQLRVLRCCNNLLLCTPQ---------------------------LAKLAMLKVLDLSHNHL-DR 361
            | |:||...:|::..:.|                           :.::..|:|||:|.|.| .:
plant   529 G-LQVLDISSNMIYDSIQEDIGMVFPNLRFMNFSSNHFQGTIPSSIGEMKSLQVLDMSSNGLYGQ 592

  Fly   362 VNLLALVPSRNLKYLDLSGNLQLQ-----------------VDEQQFKVCQSQ---SQRHWSLVD 406
            :.::.|....:|:.|.||.| |||                 :|...|.....:   ..::.:|:|
plant   593 LPIMFLSGCYSLRVLKLSNN-QLQGKIFSKHANLTGLVGLFLDGNNFTGSLEEGLLKSKNLTLLD 656

  Fly   407 VSGNNRAALPTTKIRQVS------AQRNQNK------TSGPW--TMGFAETPGSGDCRK----LS 453
            :|.|..:.:....|.::|      ...||.|      ...||  .|..:....||...:    .|
plant   657 ISDNRFSGMLPLWIGRISRLSYLYMSGNQLKGPFPFLRQSPWVEVMDISHNSFSGSIPRNVNFPS 721

  Fly   454 VYQLRAANYGGSDEALYGMFEALEGRGRAAQEMSHLVP-DLMKQEQMVKDSAVRDYMKFTLLAAQ 517
            :.:||..|                      .|.:.||| :|.|...:.......:.....:|...
plant   722 LRELRLQN----------------------NEFTGLVPGNLFKAAGLEVLDLRNNNFSGKILNTI 764

  Fly   518 QQCGSVRSAALFHLT-RTRAPSKVRPLKSKRYVLRMASTGGLDAYLIRRTSQLRLTKPDVIQKDQ 581
            .|...:|...|.:.: :|..|.|         :.:::..|.||.    ..:|.|...|....|..
plant   765 DQTSKLRILLLRNNSFQTYIPGK---------ICQLSEVGLLDL----SHNQFRGPIPSCFSKMS 816

  Fly   582 IHSMPDPHVLELILSNDDEYLV-VGNAQLWSVMDIDRAAREIRKEENSLLAAKRLVDIAQSFAAA 645
            ..:..:...:.|:...|..|:. :.:.|..|.:::|...|...:.:.:     .:||.... :..
plant   817 FGAEQNDRTMSLVADFDFSYITFLPHCQYGSHLNLDDGVRNGYQPKPA-----TVVDFLTK-SRY 875

  Fly   646 ESLSVIVVRFRHLGTDV--DHLIRELK------QSVRKKPQPVSLPLSS----GSV 689
            |:....::|:.| |.|:  :.|..|:.      |::|      ||.|||    ||:
plant   876 EAYQGDILRYMH-GLDLSSNELSGEIPIEIGDLQNIR------SLNLSSNRLTGSI 924

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Phlpp	NP_001260558.1	leucine-rich repeat	91..110	CDD:275380	6/23 (26%)
		LRR_8	109..169	CDD:290566	20/86 (23%)
		leucine-rich repeat	111..135	CDD:275380	7/24 (29%)
		leucine-rich repeat	136..158	CDD:275380	9/46 (20%)
		leucine-rich repeat	159..183	CDD:275380	4/27 (15%)
		leucine-rich repeat	184..209	CDD:275380	9/30 (30%)
		LRR_8	205..266	CDD:290566	24/67 (36%)
		leucine-rich repeat	210..230	CDD:275380	9/19 (47%)
		leucine-rich repeat	232..255	CDD:275380	7/23 (30%)
		LRR_RI	<256..410	CDD:238064	51/253 (20%)
		leucine-rich repeat	256..276	CDD:275380	8/20 (40%)
		LRR_8	279..359	CDD:290566	27/157 (17%)
		leucine-rich repeat	280..303	CDD:275380	8/73 (11%)
		leucine-rich repeat	304..348	CDD:275380	13/70 (19%)
		leucine-rich repeat	349..372	CDD:275380	8/23 (35%)
		PP2Cc	461..655	CDD:294085	31/196 (16%)
RLP1	NP_001154318.1	LRR_RI	76..>274	CDD:238064	35/126 (28%)
		leucine-rich repeat	84..112	CDD:275380
		leucine-rich repeat	113..136	CDD:275380
		LRR_8	135..194	CDD:290566	12/44 (27%)
		leucine-rich repeat	137..161	CDD:275380	5/11 (45%)
		leucine-rich repeat	162..185	CDD:275380	1/22 (5%)
		leucine-rich repeat	186..209	CDD:275380	7/22 (32%)
		LRR_8	209..270	CDD:290566	20/62 (32%)
		leucine-rich repeat	210..231	CDD:275380	6/20 (30%)
		LRR_RI	211..494	CDD:238064	69/292 (24%)
		leucine-rich repeat	232..259	CDD:275380	8/28 (29%)
		leucine-rich repeat	260..333	CDD:275380	14/75 (19%)
		leucine-rich repeat	334..359	CDD:275380	9/27 (33%)
		LRR_8	359..418	CDD:290566	23/60 (38%)
		leucine-rich repeat	360..382	CDD:275380	9/21 (43%)
		leucine-rich repeat	408..429	CDD:275380	8/20 (40%)
		leucine-rich repeat	433..455	CDD:275380	2/21 (10%)
		leucine-rich repeat	459..482	CDD:275380	0/22 (0%)
		leucine-rich repeat	483..507	CDD:275380	6/23 (26%)
		leucine-rich repeat	508..529	CDD:275380	7/20 (35%)
		leucine-rich repeat	530..554	CDD:275380	5/23 (22%)
		leucine-rich repeat	555..578	CDD:275380	0/22 (0%)
		leucine-rich repeat	579..603	CDD:275380	8/23 (35%)
		leucine-rich repeat	604..651	CDD:275380	10/47 (21%)
		LRR_RI	<638..>810	CDD:238064	37/206 (18%)
		leucine-rich repeat	652..675	CDD:275380	5/22 (23%)
		leucine-rich repeat	676..721	CDD:275380	8/44 (18%)
		LRR_8	720..780	CDD:290566	14/81 (17%)
		leucine-rich repeat	722..745	CDD:275380	9/44 (20%)
		leucine-rich repeat	746..769	CDD:275380	2/22 (9%)
		leucine-rich repeat	770..791	CDD:275380	5/29 (17%)
		leucine-rich repeat	794..815	CDD:275380	6/24 (25%)
		leucine-rich repeat	883..909	CDD:275380	6/26 (23%)
		LRR_8	909..968	CDD:290566	8/22 (36%)
		leucine-rich repeat	910..933	CDD:275380	8/21 (38%)
		leucine-rich repeat	934..957	CDD:275380
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910