DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Phlpp and ERL1

DIOPT Version :9

Sequence 1:	NP_001260558.1	Gene:	Phlpp / 35178	FlyBaseID:	FBgn0032749	Length:	954	Species:	Drosophila melanogaster
Sequence 2:	NP_201029.1	Gene:	ERL1 / 836344	AraportID:	AT5G62230	Length:	966	Species:	Arabidopsis thaliana

Alignment Length:	479	Identity:	121/479 - (25%)
Similarity:	182/479 - (37%)	Gaps:	135/479 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    44 GQTSP--------QKLSLKGSQLGGSI--LIGNYNYLTQLEVCENEME---VLDLSSLAQLETLK 95
            |:.||        |.:.|:|::|.|.|  .|||...|..|::.||.:.   ...:|.|.|||||.
plant    85 GEISPAIGDLRNLQSIDLQGNKLAGQIPDEIGNCASLVYLDLSENLLYGDIPFSISKLKQLETLN 149

  Fly    96 CSRNKLMELIINGTNLQTLVADHNYLHNISTTNTHPVPL------KLQRIDISHNN----FSELP 150
            ...|:|                           |.|||.      .|:|:|::.|:    .|.|.
plant   150 LKNNQL---------------------------TGPVPATLTQIPNLKRLDLAGNHLTGEISRLL 187

  Fly   151 NW--------------VGACAS----LTAINASHNRLNNVAVLLRNY--RITELVSLDLAYNDLK 195
            .|              .|..:|    ||.:.....|.||:...:...  ..|....||::||.:.
plant   188 YWNEVLQYLGLRGNMLTGTLSSDMCQLTGLWYFDVRGNNLTGTIPESIGNCTSFQILDISYNQIT 252

  Fly   196 QLDQFPEGFSSIRSLQLQSNELPSLPDNFFAVTHARLETLNVSCNKL-STLPRYEQNNHAALVNL 259
            ....:..||..:.:|.||.|.|.........:..| |..|::|.|:| ..:|       ..|.||
plant   253 GEIPYNIGFLQVATLSLQGNRLTGRIPEVIGLMQA-LAVLDLSDNELVGPIP-------PILGNL 309

  Fly   260 S------LAGNHLNDSIFEPLHNAAKLRVLHLAYNR-IGVLPAACVRNWPEL-------EILVLS 310
            |      |.||.|...|...|.|.::|..|.|..|: :|.:|       |||       |:.:.:
plant   310 SFTGKLYLHGNMLTGPIPSELGNMSRLSYLQLNDNKLVGTIP-------PELGKLEQLFELNLAN 367

  Fly   311 GNMLQQLPEEVATLGQLRVLRCCNNLLLCTPQLA--KLAMLKVLDLSHNHLDRVNLLALVPSR-- 371
            ..::..:|..:::...|.......|||..:..||  .|..|..|:||.|     |....:|..
plant   368 NRLVGPIPSNISSCAALNQFNVHGNLLSGSIPLAFRNLGSLTYLNLSSN-----NFKGKIPVELG 427

  Fly   372 ---NLKYLDLSGN-----LQLQVDEQQFKVCQSQSQRHWS--------------LVDVSGNNRAA 414
               ||..||||||     :.|.:.:.:..:..:.|:.|.|              ::|||.|..:.
plant   428 HIINLDKLDLSGNNFSGSIPLTLGDLEHLLILNLSRNHLSGQLPAEFGNLRSIQMIDVSFNLLSG 492

  Fly   415 LPTTKIRQV----SAQRNQNKTSG 434
            :..|::.|:    |...|.||..|
plant   493 VIPTELGQLQNLNSLILNNNKLHG 516

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Phlpp	NP_001260558.1	leucine-rich repeat	91..110	CDD:275380	6/18 (33%)
		LRR_8	109..169	CDD:290566	15/87 (17%)
		leucine-rich repeat	111..135	CDD:275380	4/29 (14%)
		leucine-rich repeat	136..158	CDD:275380	8/39 (21%)
		leucine-rich repeat	159..183	CDD:275380	5/25 (20%)
		leucine-rich repeat	184..209	CDD:275380	6/24 (25%)
		LRR_8	205..266	CDD:290566	19/67 (28%)
		leucine-rich repeat	210..230	CDD:275380	5/19 (26%)
		leucine-rich repeat	232..255	CDD:275380	6/23 (26%)
		LRR_RI	<256..410	CDD:238064	51/193 (26%)
		leucine-rich repeat	256..276	CDD:275380	10/25 (40%)
		LRR_8	279..359	CDD:290566	23/89 (26%)
		leucine-rich repeat	280..303	CDD:275380	6/23 (26%)
		leucine-rich repeat	304..348	CDD:275380	10/52 (19%)
		leucine-rich repeat	349..372	CDD:275380	7/27 (26%)
		PP2Cc	461..655	CDD:294085
ERL1	NP_201029.1	PLN00113	12..916	CDD:215061	121/479 (25%)
		leucine-rich repeat	73..96	CDD:275380	3/10 (30%)
		leucine-rich repeat	97..120	CDD:275380	9/22 (41%)
		leucine-rich repeat	121..144	CDD:275380	6/22 (27%)
		leucine-rich repeat	145..168	CDD:275380	10/49 (20%)
		leucine-rich repeat	169..192	CDD:275380	7/22 (32%)
		leucine-rich repeat	193..216	CDD:275380	3/22 (14%)
		leucine-rich repeat	217..240	CDD:275380	3/22 (14%)
		leucine-rich repeat	241..263	CDD:275380	6/21 (29%)
		leucine-rich repeat	266..287	CDD:275380	5/20 (25%)
		leucine-rich repeat	288..311	CDD:275380	9/29 (31%)
		leucine-rich repeat	312..335	CDD:275380	7/22 (32%)
		leucine-rich repeat	336..359	CDD:275380	9/29 (31%)
		leucine-rich repeat	360..383	CDD:275380	2/22 (9%)
		leucine-rich repeat	384..407	CDD:275380	7/22 (32%)
		leucine-rich repeat	408..431	CDD:275380	7/27 (26%)
		leucine-rich repeat	432..455	CDD:275380	8/22 (36%)
		leucine-rich repeat	456..479	CDD:275380	3/22 (14%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910