DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Phlpp and AT5G48770

DIOPT Version :9

Sequence 1:	NP_001260558.1	Gene:	Phlpp / 35178	FlyBaseID:	FBgn0032749	Length:	954	Species:	Drosophila melanogaster
Sequence 2:	NP_199688.1	Gene:	AT5G48770 / 834935	AraportID:	AT5G48770	Length:	1190	Species:	Arabidopsis thaliana

Alignment Length:	520	Identity:	113/520 - (21%)
Similarity:	177/520 - (34%)	Gaps:	164/520 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    73 LEVCE-NEMEVLDLSSLAQLETL------KCSRNKLMELIINGTNLQTLVADHNYLHNISTTNTH 130
            |.:|| .....:|.|:..|:|.|      |...::..:|.||..|...|......||    .:.:
plant   532 LHMCELPRAASIDGSAFEQMENLIFLKFFKHLNDRESKLNINSKNRMVLPRSLRLLH----WDAY 592

  Fly   131 PVPLKLQRIDIS-----HNNFSELPN-WVGACASLTA----INASHNRLNNVAVLLRNYRITELV 185
            |:...|....:|     |..:|.|.| |.|..:.|..    :..|.| |..:..|.|..::.||:
plant   593 PLTTLLPTFPLSRLVELHLRYSNLENLWDGKMSLLELRMLDVTGSKN-LTKLPDLSRATKLEELI 656

  Fly   186 SLDLAYNDLKQLDQFPEGFSSIRS--------------LQLQSNELPSL---PDNFFAVTHARLE 233
            :     ....:|:|.||...|:.|              ||:...|||:|   ....|........
plant   657 A-----KGCTRLEQIPETIGSLPSLKKLDVSHCDRLINLQMIIGELPALQKRSPGLFRQASLSFP 716

  Fly   234 TLNVSCNKLSTLPRYEQNNHAALVNLSLAGNHL------------------NDSIFEPLHNAAKL 280
            ...|:.|.|::|..:.:.|. .|.:|....:||                  ...:....:....|
plant   717 DAVVTLNSLTSLAIHGKLNF-WLSHLRGKADHLCFSSEQWTPNKFLKQVQKTPKLMSEFYGFKSL 780

  Fly   281 RVLHLAYNR--------------------------------IGVLPAACVRNWPELEILVLSGNM 313
            .::...|.:                                ||:|..        |:.|.||||.
plant   781 DIMQFIYRKDSASFQCYSFSDFLWLTELNLINLNIESIPDDIGLLQV--------LQKLDLSGND 837

  Fly   314 LQQLPEEVATLGQLRVLRCCNNLLLCTPQLAKLAMLKVLDLSHNHLDRVNLLALVPSRNLKYLDL 378
            ...||.::..|..::.||.||.|.|.|  |.||..|:.|.||:..|.:..|
plant   838 FTCLPTDMENLSSMKSLRLCNCLKLQT--LPKLPQLETLKLSNCILLQSPL-------------- 886

  Fly   379 SGNLQLQVDEQQFKVCQ------------SQSQRH---WSLVDVSGNNRAALPTTKIRQVSAQRN 428
             |:...:.||:.:::.:            |.:..|   .:.:|:|||:...:|.| ||
plant   887 -GHSAARKDERGYRLAELWLDNCNDVFELSYTFSHCTNLTYLDLSGNDMVTMPVT-IR------- 942

  Fly   429 QNKTSGPWTMGFAETPGSGDCRKL-SVYQLRAANYGGSDEALYGMFEALEGRGRAAQEMSHLVPD 492
                    .:....|....||:|| |:.||..            ...:|..||..:.|:.||..|
plant   943 --------FLRLLNTLCLNDCKKLKSMVQLPP------------NLTSLYARGCTSLEIIHLPLD 987

Fly 493 492
plant 988 987

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Phlpp	NP_001260558.1	leucine-rich repeat	91..110	CDD:275380	6/24 (25%)
		LRR_8	109..169	CDD:290566	16/69 (23%)
		leucine-rich repeat	111..135	CDD:275380	4/23 (17%)
		leucine-rich repeat	136..158	CDD:275380	8/27 (30%)
		leucine-rich repeat	159..183	CDD:275380	6/27 (22%)
		leucine-rich repeat	184..209	CDD:275380	6/24 (25%)
		LRR_8	205..266	CDD:290566	16/77 (21%)
		leucine-rich repeat	210..230	CDD:275380	7/22 (32%)
		leucine-rich repeat	232..255	CDD:275380	5/22 (23%)
		LRR_RI	<256..410	CDD:238064	41/218 (19%)
		leucine-rich repeat	256..276	CDD:275380	4/37 (11%)
		LRR_8	279..359	CDD:290566	28/111 (25%)
		leucine-rich repeat	280..303	CDD:275380	5/54 (9%)
		leucine-rich repeat	304..348	CDD:275380	19/43 (44%)
		leucine-rich repeat	349..372	CDD:275380	6/22 (27%)
		PP2Cc	461..655	CDD:294085	7/32 (22%)
AT5G48770	NP_199688.1	PLN03210	14..1135	CDD:215633	113/520 (22%)
		TIR	14..178	CDD:279864
		leucine-rich repeat	606..625	CDD:275380	6/18 (33%)
		LRR_3	606..622	CDD:285026	5/15 (33%)
		leucine-rich repeat	626..651	CDD:275380	6/25 (24%)
		leucine-rich repeat	652..675	CDD:275380	7/27 (26%)
		leucine-rich repeat	676..724	CDD:275380	8/47 (17%)
		leucine-rich repeat	725..779	CDD:275380	7/54 (13%)
		leucine-rich repeat	805..827	CDD:275380	3/21 (14%)
		leucine-rich repeat	828..850	CDD:275380	9/21 (43%)
		leucine-rich repeat	851..870	CDD:275380	10/20 (50%)
		leucine-rich repeat	871..899	CDD:275380	9/42 (21%)
		leucine-rich repeat	900..923	CDD:275380	2/22 (9%)
		leucine-rich repeat	924..946	CDD:275380	8/37 (22%)
		leucine-rich repeat	947..978	CDD:275380	11/42 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X32
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.000