DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Phlpp and AT5G46450

DIOPT Version :9

Sequence 1:	NP_001260558.1	Gene:	Phlpp / 35178	FlyBaseID:	FBgn0032749	Length:	954	Species:	Drosophila melanogaster
Sequence 2:	NP_199457.1	Gene:	AT5G46450 / 834688	AraportID:	AT5G46450	Length:	1123	Species:	Arabidopsis thaliana

Alignment Length:	363	Identity:	75/363 - (20%)
Similarity:	138/363 - (38%)	Gaps:	109/363 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    70 LTQLEVCENEMEVLDLSSLAQLETLKCSRNKLMELIINGTNLQTLVADHNYLHNISTTNTHPVPL 134
            |.:|::||:::|                  ||.:.:.:.|.|:.:  |.....|:.......:..
plant   607 LVKLQMCESKLE------------------KLWDGVHSLTGLRNM--DLRGSENLKEIPDLSLAT 651

  Fly   135 KLQRIDISHNNFSELPNWVGACASLTAINASHNRLNNVAVL-------LRNYRITELVSLDLAY- 191
            .|:::|:|:            |.||..::::...||.:..|       |.|..|.  ::|:..|
plant   652 NLKKLDVSN------------CTSLVELSSTIQNLNQLEELQMERCENLENLPIG--INLESLYC 702

  Fly   192 ---NDLKQLDQFPEGFSSIRSLQLQSNELPSLPDNFFAVTHARLETLNVSCNKLSTLPRYEQNNH 253
               |...:|..||:..::|..|.|....:...|      |...||.|..       |..|:..:.
plant   703 LNLNGCSKLRSFPDISTTISELYLSETAIEEFP------TELHLENLYY-------LGLYDMKSE 754

  Fly   254 ------------AALVNLSLAGNHLND--------SIFEPLHNAAKLRVLHLAYNRIGVLP---- 294
                        ..:::.||....|:|        |.|:.|||...|.:...  ..:..||
plant   755 KLWKRVQPLTPLMTMLSPSLTKLFLSDIPSLVELPSSFQNLHNLEHLNIARC--TNLETLPTGVN 817

  Fly   295 ---------AAC--VRNWPELEI----LVLSGNMLQQLP---EEVATLGQLRVLRCCNNLLLCTP 341
                     :.|  :|::|::..    |||.|..::::|   |:...|..|.::. ||||...:.
plant   818 LELLEQLDFSGCSRLRSFPDISTNIFSLVLDGTGIEEVPWWIEDFYRLSFLSMIG-CNNLQGVSL 881

  Fly   342 QLAKLAMLKVLD------LSHNHLDRVNLLALVPSRNL 373
            .::||..|:.:|      |||.:.|.:.....:.:.|:
plant   882 NISKLEKLETVDFSDCEALSHANWDTIPSAVAMATENI 919

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Phlpp	NP_001260558.1	leucine-rich repeat	91..110	CDD:275380	2/18 (11%)
		LRR_8	109..169	CDD:290566	10/59 (17%)
		leucine-rich repeat	111..135	CDD:275380	3/23 (13%)
		leucine-rich repeat	136..158	CDD:275380	4/21 (19%)
		leucine-rich repeat	159..183	CDD:275380	7/30 (23%)
		leucine-rich repeat	184..209	CDD:275380	7/28 (25%)
		LRR_8	205..266	CDD:290566	12/72 (17%)
		leucine-rich repeat	210..230	CDD:275380	4/19 (21%)
		leucine-rich repeat	232..255	CDD:275380	5/34 (15%)
		LRR_RI	<256..410	CDD:238064	36/154 (23%)
		leucine-rich repeat	256..276	CDD:275380	7/27 (26%)
		LRR_8	279..359	CDD:290566	25/107 (23%)
		leucine-rich repeat	280..303	CDD:275380	5/37 (14%)
		leucine-rich repeat	304..348	CDD:275380	14/50 (28%)
		leucine-rich repeat	349..372	CDD:275380	6/28 (21%)
		PP2Cc	461..655	CDD:294085
AT5G46450	NP_199457.1	PLN03210	1..1123	CDD:215633	75/363 (21%)
		TIR	13..178	CDD:279864
		AAA_16	185..>234	CDD:289934
		NK	212..>242	CDD:302627
		leucine-rich repeat	557..584	CDD:275380
		leucine-rich repeat	585..606	CDD:275380
		LRR_3	606..624	CDD:285026	7/34 (21%)
		leucine-rich repeat	607..629	CDD:275380	7/39 (18%)
		AMN1	<626..714	CDD:187754	20/103 (19%)
		leucine-rich repeat	630..652	CDD:275380	3/23 (13%)
		leucine-rich repeat	653..676	CDD:275380	7/34 (21%)
		leucine-rich repeat	677..699	CDD:275380	5/23 (22%)
		leucine-rich repeat	700..720	CDD:275380	5/19 (26%)
		leucine-rich repeat	721..742	CDD:275380	6/26 (23%)
		leucine-rich repeat	743..773	CDD:275380	3/36 (8%)
		leucine-rich repeat	774..797	CDD:275380	6/22 (27%)
		leucine-rich repeat	798..820	CDD:275380	3/23 (13%)
		leucine-rich repeat	842..867	CDD:275380	7/24 (29%)
		leucine-rich repeat	868..888	CDD:275380	7/20 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X32
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.000