DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Phlpp and FLS2

DIOPT Version :9

Sequence 1:	NP_001260558.1	Gene:	Phlpp / 35178	FlyBaseID:	FBgn0032749	Length:	954	Species:	Drosophila melanogaster
Sequence 2:	NP_001330009.1	Gene:	FLS2 / 834676	AraportID:	AT5G46330	Length:	1173	Species:	Arabidopsis thaliana

Alignment Length:	731	Identity:	168/731 - (22%)
Similarity:	271/731 - (37%)	Gaps:	197/731 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    51 LSLKGSQLGGSI--------------------------LIGNYNYLTQLEVCENEME---VLDLS 86
            |.|.|:||.|.|                          .|||.:.|.|||:.:|::.   ..:|.
plant   221 LDLSGNQLTGKIPRDFGNLLNLQSLVLTENLLEGDIPAEIGNCSSLVQLELYDNQLTGKIPAELG 285

  Fly    87 SLAQLETLKCSRNKLMELIING----TNLQTLVADHNY-------------------LHNISTTN 128
            :|.||:.|:..:|||...|.:.    |.|..|....|:                   ||:.:.|.
plant   286 NLVQLQALRIYKNKLTSSIPSSLFRLTQLTHLGLSENHLVGPISEEIGFLESLEVLTLHSNNFTG 350

  Fly   129 THPVPL----KLQRIDISHNNFS-ELPNWVGACASLTAINASHNRLNN-VAVLLRNYRITELVSL 187
            ..|..:    .|..:.:..||.| |||..:|...:|..::|..|.|.. :...:.|  .|.|..|
plant   351 EFPQSITNLRNLTVLTVGFNNISGELPADLGLLTNLRNLSAHDNLLTGPIPSSISN--CTGLKLL 413

  Fly   188 DLAYNDLKQLDQFPEGFS--SIRSLQLQSNELP-SLPDNFFAVTHARLETLNVSCNKLSTLPRYE 249
            ||::|.:  ..:.|.||.  ::..:.:..|... .:||:.|            :|:.|.|
plant   414 DLSHNQM--TGEIPRGFGRMNLTFISIGRNHFTGEIPDDIF------------NCSNLET----- 459

  Fly   250 QNNHAALVNLSLAGNHLNDSIFEPLHNAAKLRVLHLAYNRI-GVLPAACVRNWPELEILVLSGN- 312
                     ||:|.|:|..::...:....|||:|.::||.: |.:|.. :.|..:|.||.|..|
plant   460 ---------LSVADNNLTGTLKPLIGKLQKLRILQVSYNSLTGPIPRE-IGNLKDLNILYLHSNG 514

  Fly   313 MLQQLPEEVATLGQLRVLRCCNNLL--LCTPQLAKLAMLKVLDLSHNHLDRVNLLALVPS----- 370
            ...::|.|::.|..|:.||..:|.|  ....::..:.:|.|||||:|...     ..:|:
plant   515 FTGRIPREMSNLTLLQGLRMYSNDLEGPIPEEMFDMKLLSVLDLSNNKFS-----GQIPALFSKL 574

  Fly   371 RNLKYLDLSGNLQLQVDEQQFKVCQSQSQRHWSLV---DVSGNNRAA------LPTTKIRQVSAQ 426
            .:|.||.|.||        :|......|.:..||:   |:|.|....      |.:.|..|:...
plant   575 ESLTYLSLQGN--------KFNGSIPASLKSLSLLNTFDISDNLLTGTIPGELLASLKNMQLYLN 631

  Fly   427 RNQNKTSG--PWTMGFAETPGSGD----------------CRKLSVYQLRAANYGG--SDEALYG 471
            .:.|..:|  |..:|..|.....|                |:.:........|..|  .||...|
plant   632 FSNNLLTGTIPKELGKLEMVQEIDLSNNLFSGSIPRSLQACKNVFTLDFSQNNLSGHIPDEVFQG 696

  Fly   472 MFEALE---GRGRAAQE-------MSHLVP-DLMKQE---QMVKDSAVRDYMKFTLLAAQQQCGS 522
            |...:.   .|...:.|       |:|||. ||....   ::.:..|....:|...||:....|.
plant   697 MDMIISLNLSRNSFSGEIPQSFGNMTHLVSLDLSSNNLTGEIPESLANLSTLKHLKLASNNLKGH 761

  Fly   523 VRSAALFH-------LTRTRAPSKVRPLK-----------SKRYVLRMASTGGLDAYLIRRTSQL 569
            |..:.:|.       :..|......:|||           |||..:.:...|...|.|:.....|
plant   762 VPESGVFKNINASDLMGNTDLCGSKKPLKPCTIKQKSSHFSKRTRVILIILGSAAALLLVLLLVL 826

  Fly   570 RLT----KPDVIQKDQIHSMPD-----------PHVLELILSNDDEYLVVGNAQLWSVMDIDRAA 619
            .||    |...|:.....|:||           |..||....:.:...::|::.|.:|.
plant   827 ILTCCKKKEKKIENSSESSLPDLDSALKLKRFEPKELEQATDSFNSANIIGSSSLSTVY------ 885

  Fly   620 REIRKEENSLLAAKRL 635
             :.:.|:.:::|.|.|
plant   886 -KGQLEDGTVIAVKVL 900

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Phlpp	NP_001260558.1	leucine-rich repeat	91..110	CDD:275380	6/22 (27%)
		LRR_8	109..169	CDD:290566	19/83 (23%)
		leucine-rich repeat	111..135	CDD:275380	7/46 (15%)
		leucine-rich repeat	136..158	CDD:275380	8/22 (36%)
		leucine-rich repeat	159..183	CDD:275380	5/24 (21%)
		leucine-rich repeat	184..209	CDD:275380	8/26 (31%)
		LRR_8	205..266	CDD:290566	11/63 (17%)
		leucine-rich repeat	210..230	CDD:275380	4/20 (20%)
		leucine-rich repeat	232..255	CDD:275380	3/22 (14%)
		LRR_RI	<256..410	CDD:238064	47/165 (28%)
		leucine-rich repeat	256..276	CDD:275380	5/19 (26%)
		LRR_8	279..359	CDD:290566	29/83 (35%)
		leucine-rich repeat	280..303	CDD:275380	8/23 (35%)
		leucine-rich repeat	304..348	CDD:275380	13/46 (28%)
		leucine-rich repeat	349..372	CDD:275380	8/27 (30%)
		PP2Cc	461..655	CDD:294085	49/224 (22%)
FLS2	NP_001330009.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910