DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Phlpp and RPS4

DIOPT Version :9

Sequence 1:NP_001260558.1 Gene:Phlpp / 35178 FlyBaseID:FBgn0032749 Length:954 Species:Drosophila melanogaster
Sequence 2:NP_199338.1 Gene:RPS4 / 834561 AraportID:AT5G45250 Length:1217 Species:Arabidopsis thaliana


Alignment Length:595 Identity:126/595 - (21%)
Similarity:204/595 - (34%) Gaps:181/595 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly     6 RKQADPYKSKLKVSASHSGPHPLPV------EVTAAEEE---QAATFGQTSPQKLS--LKGSQLG 59
            :|..|.:.||:|..|....|:.:.|      |:|.|:::   ..|.|.......:.  |..|.||
plant   417 KKSMDHWNSKMKKLAQSPSPNIVSVFQVSYDELTTAQKDAFLDIACFRSQDKDYVESLLASSDLG 481

  Fly    60 GSILIGNYNYLTQ---LEVCENEMEVLDLSSLAQLET-LKCS--------RNKLMELIINGTNLQ 112
            .:..:.....||.   :..|:..:|:.||......|. ||.|        |..|.:.||.|..: 
plant   482 SAEAMSAVKSLTDKFLINTCDGRVEMHDLLYKFSREVDLKASNQDGSRQRRLWLHQHIIKGGII- 545

  Fly   113 TLVADHNYLHN-ISTTNTHPVPLKLQRID----------ISHNNFSELPNWVGACASLTAINASH 166
                  |.|.| :...|...:.|.|..::          |:..|...|..:...|......|   
plant   546 ------NVLQNKMKAANVRGIFLDLSEVEDETSLDRDHFINMGNLRYLKFYNSHCPQECKTN--- 601

  Fly   167 NRLN--------------------NVAVLLRNYRITELVSLDLAYNDLKQLDQFPEGFSSIRSLQ 211
            |::|                    .:..|..::....||.|.|.|::::||.:..:....:|.:.
plant   602 NKINIPDKLKLPLKEVRCLHWLKFPLETLPNDFNPINLVDLKLPYSEMEQLWEGDKDTPCLRWVD 666

  Fly   212 L-QSNELPSLPDNFFAVTHA-RLETLNV-SCNKLSTLPRYEQNNHAALVNLSLAGNHLNDSIFEP 273
            | .|::|.||.    .::.| :|:.||: .|..|...| ::......|..|:|.|....:|:  |
plant   667 LNHSSKLCSLS----GLSKAEKLQRLNLEGCTTLKAFP-HDMKKMKMLAFLNLKGCTSLESL--P 724

  Fly   274 LHNAAKLRVLHLAYNRIGVLPAACVRNWP----ELEILVLSGNMLQQLP---------------- 318
            ..|...|:.|.|:       ..:..:.:|    .:|.|.|.|..:.|||                
plant   725 EMNLISLKTLTLS-------GCSTFKEFPLISDNIETLYLDGTAISQLPMNMEKLQRLVVLNMKD 782

  Fly   319 ----EEV-ATLGQLRVLR------CCN------------NLLL---------------------- 338
                ||: ..:|:|:.|:      |.|            |:||                      
plant   783 CKMLEEIPGRVGELKALQELILSDCLNLKIFPEIDISFLNILLLDGTAIEVMPQLPSVQYLCLSR 847

  Fly   339 -----CTP-QLAKLAMLKVLDLSHNHLDRVNLLALVPS--RNLKYLDLSGNLQLQVDEQQFKVCQ 395
                 |.| .:::|:.||.|||.:     ...|..||.  .||:.||..|...|:...:......
plant   848 NAKISCLPVGISQLSQLKWLDLKY-----CTSLTSVPEFPPNLQCLDAHGCSSLKTVSKPLARIM 907

  Fly   396 SQSQRHWSLVDVSGNNRAALPTTKIRQVSAQRNQNKTSGPWTMGFAETPGSGDCRKLSVYQLRAA 460
            ...|.|.:.:..:..|.......:|... |||.                    |:.|| |..:..
plant   908 PTEQNHSTFIFTNCENLEQAAKEEITSY-AQRK--------------------CQLLS-YARKRY 950

  Fly   461 NYGGSDEALY 470
            |.|...|:|:
plant   951 NGGLVSESLF 960

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PhlppNP_001260558.1 leucine-rich repeat 91..110 CDD:275380 9/27 (33%)
LRR_8 109..169 CDD:290566 12/70 (17%)
leucine-rich repeat 111..135 CDD:275380 4/24 (17%)
leucine-rich repeat 136..158 CDD:275380 5/31 (16%)
leucine-rich repeat 159..183 CDD:275380 4/43 (9%)
leucine-rich repeat 184..209 CDD:275380 7/24 (29%)
LRR_8 205..266 CDD:290566 17/63 (27%)
leucine-rich repeat 210..230 CDD:275380 5/20 (25%)
leucine-rich repeat 232..255 CDD:275380 6/23 (26%)
LRR_RI <256..410 CDD:238064 47/226 (21%)
leucine-rich repeat 256..276 CDD:275380 6/19 (32%)
LRR_8 279..359 CDD:290566 29/150 (19%)
leucine-rich repeat 280..303 CDD:275380 4/26 (15%)
leucine-rich repeat 304..348 CDD:275380 20/110 (18%)
leucine-rich repeat 349..372 CDD:275380 8/24 (33%)
PP2Cc 461..655 CDD:294085 4/10 (40%)
RPS4NP_199338.1 PLN03210 16..1108 CDD:215633 126/595 (21%)
TIR 16..177 CDD:279864
AAA_16 208..343 CDD:289934
LRR_3 638..657 CDD:285026 7/18 (39%)
leucine-rich repeat 662..684 CDD:275381 7/25 (28%)
leucine-rich repeat 685..708 CDD:275380 6/23 (26%)
leucine-rich repeat 709..730 CDD:275380 7/22 (32%)
leucine-rich repeat 731..751 CDD:275380 4/26 (15%)
leucine-rich repeat 752..774 CDD:275380 7/21 (33%)
leucine-rich repeat 775..798 CDD:275380 4/22 (18%)
leucine-rich repeat 799..820 CDD:275380 3/20 (15%)
leucine-rich repeat 821..839 CDD:275380 3/17 (18%)
leucine-rich repeat 840..863 CDD:275380 3/22 (14%)
leucine-rich repeat 864..884 CDD:275380 8/24 (33%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X32
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
11.000

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