DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Phlpp and AT5G45060

DIOPT Version :9

Sequence 1:	NP_001260558.1	Gene:	Phlpp / 35178	FlyBaseID:	FBgn0032749	Length:	954	Species:	Drosophila melanogaster
Sequence 2:	NP_001330960.1	Gene:	AT5G45060 / 834537	AraportID:	AT5G45060	Length:	1165	Species:	Arabidopsis thaliana

Alignment Length:	749	Identity:	161/749 - (21%)
Similarity:	247/749 - (32%)	Gaps:	209/749 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    49 QKLSLKGSQLGGSILIGNYNYLTQLEVCENEMEV--------------LDLSSLAQLETLKCSRN 99
            ::|.||.|..|||       ...:|.|.::.:.|              ||||.: ::||   |.:
plant   521 RELDLKASTQGGS-------KQRRLWVRQDIINVQQKTMGAANVRGIFLDLSEV-KVET---SLD 574

  Fly   100 KLMELIINGTNLQTLVADHNYL-HNISTTNTHPVP----LKLQRIDISH---NNFSELPN----- 151
            :  |...|..||:.|...:::. |...|.|...:|    |.|:.:...|   ....||||
plant   575 R--EHFKNMRNLRYLKLYNSHCPHECLTNNKINMPDGLELPLKEVRCLHWLKFPLEELPNDFDPI 637

  Fly   152 --------------------------WV-----GACASLTAINASHN--RLN----NVAVLLRNY 179
                                      ||     ....||:.::.:.|  |||    .....||:.
plant   638 NLVDLKLPYSEIERLWDGVKDTPVLKWVDLNHSSKLCSLSGLSKAQNLQRLNLEGCTSLESLRDV 702

  Fly   180 RITELVSLDLA-YNDLKQLDQFPEGFSSIRSLQLQSNELPSLPDNFFAVTHARLETLNV-SCNKL 242
            .:|.|.:|.|: .::.|:....||   ::::|.|....:..||||...:  .||..||: .|..|
plant   703 NLTSLKTLTLSNCSNFKEFPLIPE---NLKALYLDGTSISQLPDNVGNL--KRLVLLNMKDCKVL 762

  Fly   243 STLPRYEQNNHAALVNLSLAG-NHLNDSIFEPLHNAAKLRVLHLAYNRIGVLPAACVRNWPELEI 306
            .|:|.. .:....|..|.|:| :.|.:.   |..|.:.|::|.|....|..:|     ..|.::.
plant   763 ETIPTC-VSELKTLQKLVLSGCSKLKEF---PEINKSSLKILLLDGTSIKTMP-----QLPSVQY 818

  Fly   307 LVLSGN-MLQQLPEEVATLGQLRVLRCCNNLLLCTPQLAKLAMLKVLDLSHNHLDRVNLLALVPS 370
            |.||.| .|..||..:..:.||..|    :|..||.                       |..||.
plant   819 LCLSRNDHLIYLPAGINQVSQLTRL----DLKYCTK-----------------------LTYVPE 856

  Fly   371 --RNLKYLDLSGNLQLQVDEQQFKVCQSQSQRHWSLVDVSGNNRAALPTTKIRQVSAQRNQNKTS 433
              ..|:|||..|...|:...:......|..|.|::....:..|.......:|... |||.....|
plant   857 LPPTLQYLDAHGCSSLKNVAKPLARIMSTVQNHYTFNFTNCGNLEQAAKEEITSY-AQRKCQLLS 920

  Fly   434 GPWTMGFAETPGSGDCRKLSVYQLRAANYGGSDEALYG-MFEALEGRGRAAQEMSHLVPDLMKQE 497
                          |.||         :|....|||:. .|...|    ......|.....:.|.
plant   921 --------------DARK---------HYNEGSEALFSTCFPGCE----VPSWFGHEAVGSLLQR 958

  Fly   498 QMVKDSAVRDYMKFTLLAAQQQCGSVRSAALFHLTRTRAPSKVRPLKSKRYVLRMASTGGLDAYL 562
            :::.....:......|.|......|....:.|.:|.|   .|:: .:.|.:|......|     :
plant   959 KLLPHWHDKRLSGIALCAVVSFPDSQDQLSCFSVTCT---FKIK-AEDKSWVPFTCPVG-----I 1014

  Fly   563 IRRTSQLRLTKPDVIQKDQ--IHSMPDPHVLELILSNDDEYLVVGNAQLWSVMDIDRA------- 618
            ..|..    .|.|.|:.|.  |..:..||.:..:...:.:......|.|...:..|.:
plant  1015 WTREG----NKKDRIESDHVFIAYISSPHSIRCLEEKNSDKCNFSEASLEFTVTSDTSGIGVFKV 1075

  Fly   619 -------AREIRKEENSLLAAKRLVDIAQSFAAAESLSVIVVRFRHLGTDVDHLIRELKQSVRKK 676
                   ..|..|.:||.|.||..|.:..||...|                 |.|.|.::.:.|:
plant  1076 LKCGLSLVYENDKNKNSSLEAKYDVPVEVSFQEPE-----------------HGIMEEERYINKR 1123

  Fly   677 PQPVSLPLSSG----------SVCKRTCCDRSNA 700
            ......|....          |...:||....||
plant  1124 RSDDRRPKKKRKTKRDDIMIISTVTQTCVPSVNA 1157

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Phlpp	NP_001260558.1	leucine-rich repeat	91..110	CDD:275380	5/18 (28%)
		LRR_8	109..169	CDD:290566	19/105 (18%)
		leucine-rich repeat	111..135	CDD:275380	6/28 (21%)
		leucine-rich repeat	136..158	CDD:275380	8/60 (13%)
		leucine-rich repeat	159..183	CDD:275380	7/29 (24%)
		leucine-rich repeat	184..209	CDD:275380	6/25 (24%)
		LRR_8	205..266	CDD:290566	18/62 (29%)
		leucine-rich repeat	210..230	CDD:275380	6/19 (32%)
		leucine-rich repeat	232..255	CDD:275380	7/23 (30%)
		LRR_RI	<256..410	CDD:238064	38/157 (24%)
		leucine-rich repeat	256..276	CDD:275380	6/20 (30%)
		LRR_8	279..359	CDD:290566	19/80 (24%)
		leucine-rich repeat	280..303	CDD:275380	5/22 (23%)
		leucine-rich repeat	304..348	CDD:275380	13/44 (30%)
		leucine-rich repeat	349..372	CDD:275380	3/24 (13%)
		PP2Cc	461..655	CDD:294085	40/210 (19%)
AT5G45060	NP_001330960.1	LRR_3	2..1082	CDD:332712	140/655 (21%)
		leucine-rich repeat	662..684	CDD:275380	4/21 (19%)
		leucine-rich repeat	685..706	CDD:275380	5/20 (25%)
		leucine-rich repeat	707..727	CDD:275380	6/22 (27%)
		leucine-rich repeat	728..750	CDD:275380	6/23 (26%)
		leucine-rich repeat	751..774	CDD:275380	7/23 (30%)
		leucine-rich repeat	775..796	CDD:275380	7/23 (30%)
		leucine-rich repeat	840..860	CDD:275380	8/46 (17%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X32
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.000