DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Phlpp and LAZ5

DIOPT Version :9

Sequence 1:	NP_001260558.1	Gene:	Phlpp / 35178	FlyBaseID:	FBgn0032749	Length:	954	Species:	Drosophila melanogaster
Sequence 2:	NP_199300.1	Gene:	LAZ5 / 834517	AraportID:	AT5G44870	Length:	1170	Species:	Arabidopsis thaliana

Alignment Length:	527	Identity:	120/527 - (22%)
Similarity:	186/527 - (35%)	Gaps:	138/527 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    48 PQKLSLKGSQLGGSILIGNYNYL-TQLEVCENEME-----------VLDLSSLAQLETLKCSRNK 100
            |::::..|:....   :.|..|| ....||..|.|           .|.|..:..|..:|....|
plant   609 PEEMTFDGNIFSN---MCNLRYLKIYSSVCHKEGEGIFKFDTVREIQLPLDKVRYLHWMKYPWEK 670

  Fly   101 LMELIINGTNLQTLVADHNYLHNISTTNTHPVPLKLQRIDISHNNFSELPNWVG----------- 154
            |.. ..|..||..|...::.:..: .......|: |:..::|::  |:|.|.:|
plant   671 LPS-DFNPENLVDLELPYSSIKKV-WEGVKDTPI-LKWANLSYS--SKLTNLLGLSNAKNLERLN 730

  Fly   155 --ACASLTAINASHNRLNNVAVLLRNYRITELVSLD---------LAYNDLKQLDQFPEGFSSIR 208
              .|.||..:......:.:: |.|...|.|.|..|.         |..:|..:|::|.....::.
plant   731 LEGCTSLLKLPQEMENMKSL-VFLNMRRCTSLTCLQSIKVSSLKILILSDCSKLEEFEVISENLE 794

  Fly   209 SLQLQSNELPSLPDNFFAVTHARLETLNV-SCNKLSTLPRYEQNNHAALVNLSLAGNHLNDSIFE 272
            .|.|....:..||.....:|  ||..||: .|.:|.:||: ......||..|.|:|....:|:..
plant   795 ELYLDGTAIKGLPPAAGDLT--RLVVLNMEGCTELESLPK-RLGKQKALQELVLSGCSKLESVPT 856

  Fly   273 PLHNAAKLRVLHLAYNRIGVLPAACVRNWPELEILVLSGNM-LQQLPEEVATLGQLR--VLRCCN 334
            .:.:...||:|.|...||..:|..     ..|:.|.||.|: :..|.:.:.....|:  |::.|.
plant   857 DVKDMKHLRLLLLDGTRIRKIPKI-----KSLKCLCLSRNIAMVNLQDNLKDFSNLKCLVMKNCE 916

  Fly   335 NLLLCTPQLAK-LAMLKV-----LDLSHNHL--DRVNLLALVPSRNLKYLDLSGN---------- 381
            ||.. .|.|.| |..|.|     |:...|.|  ||:.|. |..|..|:...|..|
plant   917 NLRY-LPSLPKCLEYLNVYGCERLESVENPLVADRLTLF-LDRSEELRSTFLFTNCHNLFQDAKD 979

  Fly   382 ------------LQLQVDEQQ------FKVC-------------------QSQSQRHWSLVDVSG 409
                        |.::..||.      |..|                   :.:.:.||....:||
plant   980 SISTYAKWKCHRLAVECYEQDIVSGAFFNTCYPGYIVPSWFDHQAVGSVLEPRLEPHWYNTMLSG 1044

  Fly   410 NNRAALPTTKIRQVSAQRNQNKTSGPW----TMGFAETPGS--GDCRKLSVYQLRAANYGGSDEA 468
            ....|:       ||...||:...|.:    |:.|....||  .||           :.|..:|.
plant  1045 IALCAV-------VSFHENQDPIIGSFSVKCTLQFENEDGSLRFDC-----------DIGCLNEP 1091

  Fly   469 LYGMFEA 475
              ||.||
plant  1092 --GMIEA 1096

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Phlpp	NP_001260558.1	leucine-rich repeat	91..110	CDD:275380	5/18 (28%)
		LRR_8	109..169	CDD:290566	13/72 (18%)
		leucine-rich repeat	111..135	CDD:275380	3/23 (13%)
		leucine-rich repeat	136..158	CDD:275380	7/34 (21%)
		leucine-rich repeat	159..183	CDD:275380	4/23 (17%)
		leucine-rich repeat	184..209	CDD:275380	6/33 (18%)
		LRR_8	205..266	CDD:290566	18/61 (30%)
		leucine-rich repeat	210..230	CDD:275380	5/19 (26%)
		leucine-rich repeat	232..255	CDD:275380	7/23 (30%)
		LRR_RI	<256..410	CDD:238064	48/211 (23%)
		leucine-rich repeat	256..276	CDD:275380	5/19 (26%)
		LRR_8	279..359	CDD:290566	26/88 (30%)
		leucine-rich repeat	280..303	CDD:275380	7/22 (32%)
		leucine-rich repeat	304..348	CDD:275380	15/47 (32%)
		leucine-rich repeat	349..372	CDD:275380	10/29 (34%)
		PP2Cc	461..655	CDD:294085	6/15 (40%)
LAZ5	NP_199300.1	PLN03210	1..1144	CDD:215633	120/527 (23%)
		leucine-rich repeat	703..725	CDD:275380	6/23 (26%)
		leucine-rich repeat	726..749	CDD:275380	3/22 (14%)
		leucine-rich repeat	750..771	CDD:275380	6/21 (29%)
		leucine-rich repeat	772..792	CDD:275380	4/19 (21%)
		leucine-rich repeat	793..815	CDD:275380	5/23 (22%)
		leucine-rich repeat	816..839	CDD:275380	7/23 (30%)
		leucine-rich repeat	840..863	CDD:275380	5/22 (23%)
		leucine-rich repeat	883..909	CDD:275380	7/25 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X32
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.000