DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Phlpp and TAO1

DIOPT Version :9

Sequence 1:	NP_001260558.1	Gene:	Phlpp / 35178	FlyBaseID:	FBgn0032749	Length:	954	Species:	Drosophila melanogaster
Sequence 2:	NP_199264.1	Gene:	TAO1 / 834478	AraportID:	AT5G44510	Length:	1187	Species:	Arabidopsis thaliana

Alignment Length:	433	Identity:	107/433 - (24%)
Similarity:	184/433 - (42%)	Gaps:	104/433 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    50 KLSLKGSQL----GGSILIGNYNYLTQLEVCENEMEVLDLS---SLAQLETLKCSRNKLMEL--- 104
            |::::.|.|    .|:..|.|..:: .|..|.|..|:.|.|   :|.:|..:.|.  .|:||
plant   638 KINMRDSMLEKLWDGNEPIRNLKWM-DLSFCVNLKELPDFSTATNLQELRLINCL--SLVELPSS 699

  Fly   105 IINGTNLQTLVADHNYLHNISTTNTHPVPLKLQRIDISHNNFSELPNWVG-----------ACAS 158
            |.|.|||                      |:|..||.|  :..:||:.:|           .|:|
plant   700 IGNATNL----------------------LELDLIDCS--SLVKLPSSIGNLTNLKKLFLNRCSS 740

  Fly   159 LTAINASHNRLNNV---------AVLLRNYRITELVSLDLAYND-LKQLDQFPEGFSSIRSLQ-- 211
            |..:.:|...:.::         ::|.....|..:|:|...|.| ...|.|.|....:..:|:
plant   741 LVKLPSSFGNVTSLKELNLSGCSSLLEIPSSIGNIVNLKKVYADGCSSLVQLPSSIGNNTNLKEL 805

  Fly   212 --LQSNELPSLPDNFFAVTHARLETLNVS-CNKLSTLPRYEQNNHAALVN-LSLAGNHLND--SI 270
              |..:.|...|.:...:|  |||.||:| |..|..||        ::.| ::|...:|:|  |:
plant   806 HLLNCSSLMECPSSMLNLT--RLEDLNLSGCLSLVKLP--------SIGNVINLQSLYLSDCSSL 860

  Fly   271 FE---PLHNAAKLRVLHL-AYNRIGVLPAACVRNWPELEILVLSG-NMLQQLP---EEVATLGQL 327
            .|   .:.||..|..|:| ..:.:..||:: :.|...|:.|.|:| :.|::||   |....|..|
plant   861 MELPFTIENATNLDTLYLDGCSNLLELPSS-IWNITNLQSLYLNGCSSLKELPSLVENAINLQSL 924

  Fly   328 RVLRCCNNLLLCTPQLAKLAMLKVLDLSH-NHLDRVNLLA--LVPSRNLKYLDLSGNLQLQVDE- 388
            .::: |::|:.....:.:::.|..||:|: :.|..:||::  :||...:  || :|:.:..|..
plant   925 SLMK-CSSLVELPSSIWRISNLSYLDVSNCSSLLELNLVSHPVVPDSLI--LD-AGDCESLVQRL 985

  Fly   389 ----------QQFKVCQSQSQRHWSL-VDVSGNNRAALPTTKI 420
                      ..|..|...:|....| :..|....|.||..|:
plant   986 DCFFQNPKIVLNFANCFKLNQEARDLIIQTSACRNAILPGEKV 1028

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Phlpp	NP_001260558.1	leucine-rich repeat	91..110	CDD:275380	7/21 (33%)
		LRR_8	109..169	CDD:290566	15/70 (21%)
		leucine-rich repeat	111..135	CDD:275380	1/23 (4%)
		leucine-rich repeat	136..158	CDD:275380	8/32 (25%)
		leucine-rich repeat	159..183	CDD:275380	4/32 (13%)
		leucine-rich repeat	184..209	CDD:275380	7/25 (28%)
		LRR_8	205..266	CDD:290566	17/66 (26%)
		leucine-rich repeat	210..230	CDD:275380	5/23 (22%)
		leucine-rich repeat	232..255	CDD:275380	9/23 (39%)
		LRR_RI	<256..410	CDD:238064	44/179 (25%)
		leucine-rich repeat	256..276	CDD:275380	6/25 (24%)
		LRR_8	279..359	CDD:290566	22/85 (26%)
		leucine-rich repeat	280..303	CDD:275380	6/23 (26%)
		leucine-rich repeat	304..348	CDD:275380	12/47 (26%)
		leucine-rich repeat	349..372	CDD:275380	9/25 (36%)
		PP2Cc	461..655	CDD:294085
TAO1	NP_199264.1	PLN03210	36..1062	CDD:215633	107/433 (25%)
		TIR	42..199	CDD:279864
		leucine-rich repeat	584..613	CDD:275380
		leucine-rich repeat	614..635	CDD:275380
		LRR_3	635..653	CDD:285026	3/14 (21%)
		leucine-rich repeat	636..658	CDD:275380	5/19 (26%)
		leucine-rich repeat	659..681	CDD:275380	6/22 (27%)
		leucine-rich repeat	682..705	CDD:275380	8/24 (33%)
		AMN1	704..911	CDD:187754	58/241 (24%)
		leucine-rich repeat	706..729	CDD:275380	9/46 (20%)
		leucine-rich repeat	730..753	CDD:275380	4/22 (18%)
		leucine-rich repeat	754..801	CDD:275380	9/46 (20%)
		leucine-rich repeat	802..825	CDD:275380	5/24 (21%)
		leucine-rich repeat	826..848	CDD:275380	10/29 (34%)
		leucine-rich repeat	849..872	CDD:275380	7/22 (32%)
		leucine-rich repeat	873..896	CDD:275380	6/23 (26%)
		leucine-rich repeat	897..919	CDD:275380	8/21 (38%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X32
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.000