DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Phlpp and AT5G40060

DIOPT Version :9

Sequence 1:	NP_001260558.1	Gene:	Phlpp / 35178	FlyBaseID:	FBgn0032749	Length:	954	Species:	Drosophila melanogaster
Sequence 2:	NP_198822.3	Gene:	AT5G40060 / 834003	AraportID:	AT5G40060	Length:	968	Species:	Arabidopsis thaliana

Alignment Length:	839	Identity:	167/839 - (19%)
Similarity:	288/839 - (34%)	Gaps:	241/839 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    43 FGQTSPQKLSLKGSQLGGSILIGNYNYLTQLEVCENEMEVLDLSSLAQLETLKCSRNKL--MELI 105
            |.:.:..:|.|..|.|..:|.:.|....:.:.|..|.:|:..|......|.::...|:.  .|.:
plant   256 FEKVNDIRLLLADSDLNFNIGLENLVDKSLVNVRSNIVEMHCLLQEMGREIVRAQSNEAGEREFL 320

  Fly   106 INGTNLQTLVADHNYLHNISTTNTHPVPLKLQRID----ISHNNFSELPNWVGACASLTAINASH 166
            ::..::..::.|     ||.|.....:.|.:..||    :....|..:.|       |..:|...
plant   321 MDTEDICDVLDD-----NIGTKKMLGISLDVDEIDHELNVHEKAFQGMRN-------LRFLNIYT 373

  Fly   167 NRLNN----------------------------VAVLLRNYRITELVSLDLAYNDLKQLDQFPEG 203
            ..|.:                            :..|..::|...||.|.:..::|::|.:....
plant   374 KALMSGQKIRLHLPENFDYLPPKLKLLCWDKYPMRCLPSSFRPENLVKLKMQESELEKLWEGVGS 438

  Fly   204 FSSIRSLQLQ-SNELPSLPDNFFAVTHARLETLNVS-CNKLSTLPRYEQN-------NHAALVNL 259
            .:.::.:.|: |..|..:||...|   ..|:|||:. |:.|..:....||       |.....||
plant   439 LTCLKDMDLEKSKNLKEIPDLSMA---TNLKTLNLKYCSSLVKISSSIQNLNKLTKLNMEGCTNL 500

  Fly   260 SL--AGNHLNDSIFEPLHNAAKLRVLHLAYNRIGV--LPAACVRNWP-ELEILVLSGNMLQQLPE 319
            ..  ||.:|.......|...::||:.....|.|.|  |....:..:| .|.:..|....:||:..
plant   501 ETLPAGINLKSLHRLDLRGCSRLRMFPDISNNISVLFLDKTSIEEFPSNLHLKKLFDLSMQQMNS 565

  Fly   320 EVATLGQLRVLRCCNNLLLCTPQLAK------------LAML--------KVLDLSHNHLDRVNL 364
            |....| ::.|.|...:|  :|.|||            |..|        |:::||.....  ||
plant   566 EKLWEG-VQPLTCLMKML--SPPLAKNFNTLYLSDIPSLVELPCGIQNLKKLMELSIRRCK--NL 625

  Fly   365 LALVPSRNLK---YLDLSGNLQLQVDEQQFKVCQSQSQRHWSLVDVSGN-NRAALPTTKIRQVSA 425
            .:|....|.|   ||||||..:|:                 |..|:|.. :...|..|.|.:|.:
plant   626 ESLPTGANFKYLDYLDLSGCSKLR-----------------SFPDISSTISCLCLNRTGIEEVPS 673

  Fly   426 QRNQNKTSGPWTMGFAETP--GSGDCRKLSVYQLRAANYGGSDEALYGMFEALEGRGRAAQEMSH 488
                      |...|....  ...:|.||....|             .:|           ::.|
plant   674 ----------WIENFVRLTYLTMLECNKLKYVSL-------------NIF-----------KLKH 704

  Fly   489 LVPDLMKQEQMVKDSAVRDYMKFTLLAAQQQCGSVRSAALFHLTRTRAPSKVRPLKSKRYVLRMA 553
            |            |.|  |:         ..||::...:..:.|.:.|.:....::.|..|...:
plant   705 L------------DKA--DF---------SDCGTLTEVSWCNKTISVAAATADNIQPKLLVSEAS 746

  Fly   554 STGGLDAYLIRRTSQLRLTKPDVIQKDQIHSMPDPHVLELILSNDD-----EYLVVGNAQLWSV- 612
            |:..:...::|..:..:|.:..::|:       :|....|||..::     .:...||:.:..:
plant   747 SSLCVQKSVVRFINCFKLDQEALLQQ-------EPVFKSLILGGEEVPAYFNHRATGNSLVIPLV 804

  Fly   613 ---MDIDRAAREIRKEENSLLAAKRLVDI-AQSFAAAESLSVIVVRFR-----HLGTDVDH---- 664
               :.:|...          ..|..|||: |.|......:.| ..|||     |..: .||
plant   805 PTSISLDFLG----------FRACALVDVKAMSMPGRVDIQV-SCRFRGSLKNHFDS-ADHSHSL 857

  Fly   665 ---------LIRELKQSVRKKPQP-------VSLPLSSGSVCKRTCCDRSNACRHRAIE----QE 709
                     ||.:.:.::.....|       ::..|::.||.|      .|||..|..|    |:
plant   858 VAFHKASHLLIFDCRFALNNDSNPLNYAHMDITFHLTTDSVSK------INACGIRFSEGVSPQK 916

  Fly   710 PLAGRSSPSGQSDRDLLAKDKDDEFVLAHARVLQEEQQLEMLDETESVSESVLSEEQFK 768
            .|.|.||.....:.|....|.|..    ||...:..::.     .:|..|:|:|.::.|
plant   917 HLNGPSSIVHVCEADESKLDNDRR----HAHETEHGEEC-----GDSNVETVVSRKRIK 966

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Phlpp	NP_001260558.1	leucine-rich repeat	91..110	CDD:275380	3/20 (15%)
		LRR_8	109..169	CDD:290566	11/63 (17%)
		leucine-rich repeat	111..135	CDD:275380	4/23 (17%)
		leucine-rich repeat	136..158	CDD:275380	4/25 (16%)
		leucine-rich repeat	159..183	CDD:275380	5/51 (10%)
		leucine-rich repeat	184..209	CDD:275380	5/24 (21%)
		LRR_8	205..266	CDD:290566	19/71 (27%)
		leucine-rich repeat	210..230	CDD:275380	6/20 (30%)
		leucine-rich repeat	232..255	CDD:275380	9/30 (30%)
		LRR_RI	<256..410	CDD:238064	46/181 (25%)
		leucine-rich repeat	256..276	CDD:275380	6/21 (29%)
		LRR_8	279..359	CDD:290566	25/102 (25%)
		leucine-rich repeat	280..303	CDD:275380	7/25 (28%)
		leucine-rich repeat	304..348	CDD:275380	14/55 (25%)
		leucine-rich repeat	349..372	CDD:275380	7/30 (23%)
		PP2Cc	461..655	CDD:294085	30/203 (15%)
AT5G40060	NP_198822.3	AAA	13..150	CDD:214640
		P-loop_NTPase	17..144	CDD:304359
		leucine-rich repeat	366..396	CDD:275380	3/29 (10%)
		LRR	394..>664	CDD:227223	68/294 (23%)
		leucine-rich repeat	397..418	CDD:275380	2/20 (10%)
		LRR_3	418..436	CDD:285026	5/17 (29%)
		leucine-rich repeat	419..441	CDD:275380	5/21 (24%)
		leucine-rich repeat	442..464	CDD:275380	6/24 (25%)
		AMN1	463..651	CDD:187754	52/209 (25%)
		leucine-rich repeat	465..488	CDD:275380	8/22 (36%)
		leucine-rich repeat	489..511	CDD:275380	6/21 (29%)
		leucine-rich repeat	533..551	CDD:275380	4/17 (24%)
		leucine-rich repeat	582..610	CDD:275381	7/29 (24%)
		leucine-rich repeat	611..636	CDD:275381	7/26 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X32
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.000