DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Phlpp and AT5G18360

DIOPT Version :9

Sequence 1:	NP_001260558.1	Gene:	Phlpp / 35178	FlyBaseID:	FBgn0032749	Length:	954	Species:	Drosophila melanogaster
Sequence 2:	NP_197337.1	Gene:	AT5G18360 / 831954	AraportID:	AT5G18360	Length:	900	Species:	Arabidopsis thaliana

Alignment Length:	888	Identity:	164/888 - (18%)
Similarity:	288/888 - (32%)	Gaps:	328/888 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly    63 LIGNYNYLTQLE--VCENEMEV----------LDLSSLAQ---------------LETLKCSRNK 100
            |:|..|::.:|:  :|....||          :..:::|:               :|.:|.| ::
plant   186 LVGIDNHMRELDSLLCLESTEVKMVGIWGPAGIGKTTIARALFNRLSENFQHTIFMENVKGS-SR 249

  Fly   101 LMELIINGTNLQ------TLVADHNY--LHNISTTNTHPVPL----------KLQRIDISHNNFS 147
            ..||...|..|:      :.|.||.:  :|::.........|          ||:::|.    ..
plant   250 TSELDAYGFQLRLQEQFLSEVIDHKHMKIHDLGLVKERLQDLKVLVVLDDVDKLEQLDA----LV 310

  Fly   148 ELPNWVGACASLTAINASHNRLNNVAVLLRNYRITELVSLDLAYNDLKQLDQFPEGFSSIRSLQL 212
            :...|.|:.:.:  |..:.|:     .|||.:.||.:..|.           ||....|::....
plant   311 KQSQWFGSGSRI--IVTTENK-----QLLRAHGITCIYELG-----------FPSRSDSLQIFCQ 357

  Fly   213 QSNELPSLPDNF--FAVTHARLE-----TLNVSCNKLSTLPRYEQNNHAALVNLSLAGNHLNDSI 270
            .:....|.||..  .|....:|.     .|.|..:.|..:.:.||.  :||..|..:   ||:.|
plant   358 YAFGESSAPDGCIELATEITKLAGYLPLALKVLGSSLRGMSKDEQK--SALPRLRTS---LNEDI 417

  Fly   271 -------FEPLHNAAKLRVLHLAYNRIGVLPAACVRNWPEL----EILVLSGNMLQQLPEEVATL 324
                   ::.:|:..|:..||:          ||:.|...:    :||..||..:....:.:.:.
plant   418 RNVLRVGYDGIHDKDKVIFLHI----------ACLFNGENVDYVKQILASSGLDVTFGLQVLTSR 472

  Fly   325 GQLRVLRCCNNLLLCTPQLAKLAMLKVLDLSHNHLDRVNLLALVPSRNLKYLDLSGNLQLQVDEQ 389
            ..:.:.||...:.:                 ||.|:::       .|.:
plant   473 SLIHISRCNRTITM-----------------HNLLEQL-------GREI---------------- 497

  Fly   390 QFKVCQSQSQRHWSLVDVSGNNRAALPTTKIRQVSAQRNQNKTSGPWTMGFAETPGSG------- 447
               ||:..       :...|..:..:..::|..|                .|:..|:|
plant   498 ---VCEQS-------IAEPGKRQFLMDASEIYDV----------------LADNTGTGAVLGISL 536

  Fly   448 DCRKLSVYQLRAANYGGSDEALYGMFEALEGRGRAAQEMSHLVPDLMKQEQMVKDSAVRDYMKFT 512
            |..|::...|....:||....|:..|                          .|.|:.:|..:
plant   537 DISKINELFLNERAFGGMHNLLFLRF--------------------------YKSSSSKDQPE-- 573

  Fly   513 LLAAQQQCGSVRSAALFHLTRTRAPSKVRPLKSKRYVLRMASTGGLDAYLIRRTSQLRLTKPDVI 577
                            .||.|                       ||| ||.|:   |||...|..
plant   574 ----------------LHLPR-----------------------GLD-YLPRK---LRLLHWDAF 595

  Fly   578 QKDQIHSMPDPHVLELILSNDDEYLVVGN------AQLW-------SVMDIDRAAREIRKEENSL 629
               .:.|||        ||...::|||.|      .:||       |:..:|.:..|..||...|
plant   596 ---PMTSMP--------LSFCPQFLVVINIRESQLEKLWEGTQPLRSLKQMDLSKSENLKEIPDL 649

  Fly   630 LAAKRLVDIAQSFAAAESLSVIVVRFRHLGTDVDHLIRELKQSVRKKPQPVSLPLSSGSVCKRTC 694
            ..|..:.::..|:..  ||.::....::|...|   :.::|...:.:..|.::.|.|.|:.....
plant   650 SKAVNIEELCLSYCG--SLVMLPSSIKNLNKLV---VLDMKYCSKLEIIPCNMDLESLSILNLDG 709

  Fly   695 CDRSN------------ACRHRAIEQEPLAGRSSPSGQSDRDLLAKDKDDEFVLAHARVLQE--- 744
            |.|..            :....|||:.|....|.|.      |.|.|      ::..:.|:.
plant   710 CSRLESFPEISSKIGFLSLSETAIEEIPTTVASWPC------LAALD------MSGCKNLKTFPC 762

  Fly   745 -EQQLEMLDETESVSESVLSEEQFKCWEYMLEQNTQLLFDK--ELNTISKSFTKQRTV------- 799
             .:.:|.||.:.:..|.|      ..|...|.:..:||.:.  :|.:||...:....:
plant   763 LPKTIEWLDLSRTEIEEV------PLWIDKLSKLNKLLMNSCMKLRSISSGISTLEHIKTLDFLG 821

  Fly   800 -PNAIMAATVLPERNDFTSNL---MRTVTNKFISTSTPQLPQP 838
             .|.:.....:.|.:.|..||   ||.:.|       |.||:|
plant   822 CKNIVSFPVEIFESSRFCHNLVMEMRNIQN-------PDLPRP 857

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Phlpp	NP_001260558.1	leucine-rich repeat	91..110	CDD:275380	6/18 (33%)
		LRR_8	109..169	CDD:290566	13/77 (17%)
		leucine-rich repeat	111..135	CDD:275380	6/41 (15%)
		leucine-rich repeat	136..158	CDD:275380	4/21 (19%)
		leucine-rich repeat	159..183	CDD:275380	6/23 (26%)
		leucine-rich repeat	184..209	CDD:275380	4/24 (17%)
		LRR_8	205..266	CDD:290566	14/67 (21%)
		leucine-rich repeat	210..230	CDD:275380	4/21 (19%)
		leucine-rich repeat	232..255	CDD:275380	6/27 (22%)
		LRR_RI	<256..410	CDD:238064	24/164 (15%)
		leucine-rich repeat	256..276	CDD:275380	5/26 (19%)
		LRR_8	279..359	CDD:290566	14/83 (17%)
		leucine-rich repeat	280..303	CDD:275380	5/22 (23%)
		leucine-rich repeat	304..348	CDD:275380	6/47 (13%)
		leucine-rich repeat	349..372	CDD:275380	3/22 (14%)
		PP2Cc	461..655	CDD:294085	41/206 (20%)
AT5G18360	NP_197337.1	PLN03210	12..>822	CDD:215633	152/844 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X32
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.000