DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Phlpp and AT5G18350

DIOPT Version :9

Sequence 1:	NP_001260558.1	Gene:	Phlpp / 35178	FlyBaseID:	FBgn0032749	Length:	954	Species:	Drosophila melanogaster
Sequence 2:	NP_197336.4	Gene:	AT5G18350 / 831953	AraportID:	AT5G18350	Length:	1245	Species:	Arabidopsis thaliana

Alignment Length:	450	Identity:	98/450 - (21%)
Similarity:	178/450 - (39%)	Gaps:	131/450 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    43 FGQTSPQKLSL-KG-SQLGGSILIGNYNYLTQLEVCENEMEVLDLSSLAQLETLKCSRNKLMELI 105
            ||    .|||| :| :.|.|.:.:.::||      |.           .:|...|.|.|.|:||:
plant   585 FG----DKLSLPRGLNCLPGKLRVLHWNY------CP-----------LRLWPSKFSANFLVELV 628

  Fly   106 INGTNLQTLVADHNYLHNISTTNTHPVPLK-LQRIDISHN-NFSELPNW----------VGACAS 158
            :.|.|.:.|      ...|       :||| |:|:|:||: :..|:|:.          :.:|:.
plant   629 MRGNNFEKL------WEKI-------LPLKSLKRMDLSHSKDLKEIPDLSNATNLEELDLSSCSG 680

  Fly   159 LTAINASHNRLNNV-------AVLLRNY-----RITELVSLDLAYNDLKQLDQFPEGFSSIRSLQ 211
            |..:..|..:..|:       ..||:..     ..|.|..|||.:  .:..::.|:....:.:|:
plant   681 LLELTDSIGKATNLKRLKLACCSLLKKLPSSIGDATNLQVLDLFH--CESFEELPKSIGKLTNLK 743

  Fly   212 ----LQSNELPSLPDNFFAVTHARLETLNVS-CNKLSTLPRYEQNNHAALVNLSLAGNHLNDSIF 271
                ::..:|.:||:   ::...:|..|::| |..|...|.|        :||.   :.....:|
plant   744 VLELMRCYKLVTLPN---SIKTPKLPVLSMSECEDLQAFPTY--------INLE---DCTQLKMF 794

  Fly   272 EPLHNAAKLRVLHLAYNRIGVLPAA--------------C--VRNWPELEI----LVLSGNMLQQ 316
            ..:  :..::.|.|....|..:|::              |  ::.:|.:.:    |.||...:::
plant   795 PEI--STNVKELDLRNTAIENVPSSICSWSCLYRLDMSECRNLKEFPNVPVSIVELDLSKTEIEE 857

  Fly   317 LPEEVATLGQLRVLRC--CNNLLLCTPQLAKLAMLKVLDLSHNHL--DRVNLLALVPSRNLKYLD 377
            :|..:..|..||.|..  |..|.:.:|.::||..|:.|:|..:.:  |..:..|.|...:.....
plant   858 VPSWIENLLLLRTLTMVGCKRLNIISPNISKLKNLEDLELFTDGVSGDAASFYAFVEFSDRHDWT 922

  Fly   378 LSGNLQLQVDEQQFKVC---QSQSQRHWSL-----------------VDVSG-NNRAALP 416
            |..:.|:   .....:|   .:.|.|.||.                 :|||| .|..:||
plant   923 LESDFQV---HYILPICLPKMAISLRFWSYDFETIPDCINCLPGLSELDVSGCRNLVSLP 979

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Phlpp	NP_001260558.1	leucine-rich repeat	91..110	CDD:275380	8/18 (44%)
		LRR_8	109..169	CDD:290566	16/71 (23%)
		leucine-rich repeat	111..135	CDD:275380	3/23 (13%)
		leucine-rich repeat	136..158	CDD:275380	8/32 (25%)
		leucine-rich repeat	159..183	CDD:275380	5/35 (14%)
		leucine-rich repeat	184..209	CDD:275380	5/24 (21%)
		LRR_8	205..266	CDD:290566	13/65 (20%)
		leucine-rich repeat	210..230	CDD:275380	4/23 (17%)
		leucine-rich repeat	232..255	CDD:275380	7/23 (30%)
		LRR_RI	<256..410	CDD:238064	39/198 (20%)
		leucine-rich repeat	256..276	CDD:275380	3/19 (16%)
		LRR_8	279..359	CDD:290566	22/101 (22%)
		leucine-rich repeat	280..303	CDD:275380	5/38 (13%)
		leucine-rich repeat	304..348	CDD:275380	13/49 (27%)
		leucine-rich repeat	349..372	CDD:275380	6/24 (25%)
		PP2Cc	461..655	CDD:294085
AT5G18350	NP_197336.4	PLN03210	6..1173	CDD:215633	97/449 (22%)
		TIR	20..183	CDD:279864
		AAA_16	194..329	CDD:289934
		leucine-rich repeat	576..601	CDD:275380	8/19 (42%)
		LRR_RI	<591..723	CDD:238064	37/161 (23%)
		leucine-rich repeat	602..617	CDD:275380	4/31 (13%)
		leucine-rich repeat	624..646	CDD:275380	9/34 (26%)
		leucine-rich repeat	647..669	CDD:275380	7/21 (33%)
		AMN1	<661..761	CDD:187754	17/104 (16%)
		leucine-rich repeat	670..693	CDD:275380	3/22 (14%)
		leucine-rich repeat	694..717	CDD:275380	2/22 (9%)
		leucine-rich repeat	718..741	CDD:275380	5/24 (21%)
		leucine-rich repeat	742..778	CDD:275380	9/38 (24%)
		leucine-rich repeat	801..823	CDD:275380	4/21 (19%)
		leucine-rich repeat	824..844	CDD:275380	2/19 (11%)
		leucine-rich repeat	845..865	CDD:275380	4/19 (21%)
		leucine-rich repeat	868..891	CDD:275380	8/22 (36%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X32
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.000