DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Phlpp and DAR4

DIOPT Version :9

Sequence 1:	NP_001260558.1	Gene:	Phlpp / 35178	FlyBaseID:	FBgn0032749	Length:	954	Species:	Drosophila melanogaster
Sequence 2:	NP_197291.2	Gene:	DAR4 / 831657	AraportID:	AT5G17890	Length:	1613	Species:	Arabidopsis thaliana

Alignment Length:	924	Identity:	181/924 - (19%)
Similarity:	317/924 - (34%)	Gaps:	292/924 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    49 QKLSLKGSQLGGSILIGNYNYLTQLE-----VCE----------NEMEVLDLSSLAQL---ETLK 95
            ::|...||   ||::|     :|.::     .|:          |..|.|.|.|.:..   |..:
plant   291 KRLDWFGS---GSLII-----ITSVDKQVFAFCQINQIYTVQGLNVHEALQLFSQSVFGINEPEQ 347

  Fly    96 CSRNKLMELI--INGTNLQTLVADHNYLHNISTTNT------HPVPLKLQRIDISHNNFSELPNW 152
            ..|...|::|  :||..|...:.....:...|...|      |..|||:|  |:..|.:|.|
plant   348 NDRKLSMKVIDYVNGNPLALSIYGRELMGKKSEMETAFFELKHCPPLKIQ--DVLKNAYSAL--- 407

  Fly   153 VGACASLTAINASHNRLN---NVAVLLRNYRITELVSLDLAYNDLKQLDQFP---------EGFS 205
                        |.|..|   ::|...:...:..::.|      |::...||         :...
plant   408 ------------SDNEKNIVLDIAFFFKGETVNYVMQL------LEESHYFPRLAIDVLVDKCVL 454

  Fly   206 SIRSLQLQSNELPSLPDNFFAVTHARLETLNVSC------NKLSTLPRYEQ----NNHAALVNLS 260
            :|....:|.|.|  :.|....:.:..:||    |      :::..|..|::    ....|:....
plant   455 TISENTVQMNNL--IQDTCQEIFNGEIET----CTRMWEPSRIRYLLEYDELEGSGETKAMPKSG 513

  Fly   261 LAGNHLNDSIFEPLHNAAKLRVLHLAYNRIGVLP-----AACVR-----NWP--------ELEIL 307
            |...|: :|||....| .|..|.|.|:..:..|.     .:|.:     |:|        ||.:|
plant   514 LVAEHI-ESIFLDTSN-VKFDVKHDAFKNMFNLKFLKIYNSCSKYISGLNFPKGLDSLPYELRLL 576

  Fly   308 VLSGNMLQQLPEEVATLGQLRVLRCCNNLLLCTP--QLAK-------LAMLKVLDLSHNHLDRVN 363
            ......||.||::. ..|.|        :.|..|  ||.|       |.|||.|.|||: |..|.
plant   577 HWENYPLQSLPQDF-DFGHL--------VKLSMPYSQLHKLGTRVKDLVMLKRLILSHS-LQLVE 631

  Fly   364 LLALVPSRNLKYLDLSGNLQLQVDEQQF-KVCQSQSQRHWSLVDVSGNNRAA------------- 414
            ...|:.::|::.:||.|...|    |:| ...|.|:.|   :|::||.....
plant   632 CDILIYAQNIELIDLQGCTGL----QRFPDTSQLQNLR---VVNLSGCTEIKCFSGVPPNIEELH 689

  Fly   415 LPTTKIRQVSAQRNQNKTSGPWTMGFAETPGSGDCRKLSVYQLRAANYGGSDEALYGMFEALEGR 479
            |..|:||::..   .|.|..|               |:.:          ..:.|:.:.|..
plant   690 LQGTRIREIPI---FNATHPP---------------KVKL----------DRKKLWNLLENF--- 723

  Fly   480 GRAAQEMSHLVPDLMKQEQMVKDSAVRDYMKFTLLAAQQQCGSVR---------SAALFHLTRTR 535
                .::.|:  ||.....:...::....|...:....:.|.::|         |..:.:|:...
plant   724 ----SDVEHI--DLECVTNLATVTSNNHVMGKLVCLNMKYCSNLRGLPDMVSLESLKVLYLSGCS 782

  Fly   536 APSKV----RPLKSKRYVLRMASTGGLDAYLIRRTSQLRLTKPDVIQKDQIHSMPDPHVLELILS 596
            ...|:    |.|| |.||      ||.   .||...||    |:.::....|.......:.|...
plant   783 ELEKIMGFPRNLK-KLYV------GGT---AIRELPQL----PNSLEFLNAHGCKHLKSINLDFE 833

  Fly   597 NDDEYLVVGNAQLWS------------VMDIDRAARE---------------IRKEENSLLAAKR 634
            ....:.:..|...:|            |..:.||.:|               .|:..:..|.|.|
plant   834 QLPRHFIFSNCYRFSSQVIAEFVEKGLVASLARAKQEELIKAPEVIICIPMDTRQRSSFRLQAGR 898

  Fly   635 -----LVDIAQSFAAAESLSVIV-----------VRFRHLGT------DVDHLIRELKQ--SVRK 675
                 ||...|...:..|:||:|           :|.|.:||      ..|.::....|  :..:
plant   899 NAMTDLVPWMQKPISGFSMSVVVSFQDDYHNDVGLRIRCVGTWKTWNNQPDRIVERFFQCWAPTE 963

  Fly   676 KPQPVS-----------LPLSSGSVCKRTCCDRSNACRHRA-IEQEPLAGRSSPSGQSDR----- 723
            .|:.|:           .|..|..       :..:...|.. .|...::|.::|.|.|.:
plant   964 APKVVADHIFVLYDTKMHPSDSEE-------NHISMWAHEVKFEFHTVSGENNPLGASCKVTECG 1021

  Fly   724 -DLLAKDKDDEFVLAHARVLQEEQQLEMLDETESVSESVLSEEQFKCWEYMLEQNTQLLFDKELN 787
             :::.....|..|   :.:::|.:.:.::::    .::::.||.........|:..:.....||.
plant  1022 VEVITAATGDTSV---SGIIRESETITIIEK----EDTIIDEEDTPLLSRKPEETNRSRSSSELQ 1079

  Fly   788 TISKSFTKQRTVPN 801
            .:|.:.:|.|:..|
plant  1080 KLSSTSSKVRSKGN 1093

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Phlpp	NP_001260558.1	leucine-rich repeat	91..110	CDD:275380	6/23 (26%)
		LRR_8	109..169	CDD:290566	14/65 (22%)
		leucine-rich repeat	111..135	CDD:275380	5/29 (17%)
		leucine-rich repeat	136..158	CDD:275380	5/21 (24%)
		leucine-rich repeat	159..183	CDD:275380	4/26 (15%)
		leucine-rich repeat	184..209	CDD:275380	5/33 (15%)
		LRR_8	205..266	CDD:290566	12/70 (17%)
		leucine-rich repeat	210..230	CDD:275380	4/19 (21%)
		leucine-rich repeat	232..255	CDD:275380	5/32 (16%)
		LRR_RI	<256..410	CDD:238064	51/181 (28%)
		leucine-rich repeat	256..276	CDD:275380	5/19 (26%)
		LRR_8	279..359	CDD:290566	30/106 (28%)
		leucine-rich repeat	280..303	CDD:275380	7/40 (18%)
		leucine-rich repeat	304..348	CDD:275380	14/52 (27%)
		leucine-rich repeat	349..372	CDD:275380	9/22 (41%)
		PP2Cc	461..655	CDD:294085	43/249 (17%)
DAR4	NP_197291.2	PLN03210	26..>844	CDD:215633	136/659 (21%)
		TIR	30..163	CDD:279864
		AAA	166..294	CDD:99707	0/2 (0%)
		leucine-rich repeat	544..572	CDD:275380	4/27 (15%)
		leucine-rich repeat	573..594	CDD:275380	6/21 (29%)
		LRR_3	594..613	CDD:285026	6/26 (23%)
		leucine-rich repeat	595..617	CDD:275380	7/29 (24%)
		leucine-rich repeat	618..640	CDD:275380	9/22 (41%)
		leucine-rich repeat	641..663	CDD:275380	7/25 (28%)
		leucine-rich repeat	685..708	CDD:275380	7/40 (18%)
		leucine-rich repeat	750..772	CDD:275380	2/21 (10%)
		leucine-rich repeat	773..793	CDD:275380	2/19 (11%)
		leucine-rich repeat	794..824	CDD:275380	13/43 (30%)
		LIM_DA1	1240..1291	CDD:188782
		DUF3633	1387..1602	CDD:289113
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X32
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.000