DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Phlpp and AT5G10020

DIOPT Version :9

Sequence 1:	NP_001260558.1	Gene:	Phlpp / 35178	FlyBaseID:	FBgn0032749	Length:	954	Species:	Drosophila melanogaster
Sequence 2:	NP_196564.1	Gene:	AT5G10020 / 830865	AraportID:	AT5G10020	Length:	1048	Species:	Arabidopsis thaliana

Alignment Length:	828	Identity:	186/828 - (22%)
Similarity:	313/828 - (37%)	Gaps:	224/828 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    51 LSLKGSQLGGSIL----IGNYNYLTQLEVCENEM--EVLDLSSLAQLETLKCSRNKL-----MEL 104
            |:|..:.|.|...    ||::..|..:::..|::  |:....|...|..||.:||:|     .||
plant   228 LNLSHNALNGKFFSEESIGSFKNLEIVDLENNQINGELPHFGSQPSLRILKLARNELFGLVPQEL 292

  Fly   105 IINGTNLQTLVADHN-YLHNISTTNTHPVPLKLQRIDISHNNFS-ELPNWVGACASLTAINASHN 167
            :.:...|..|....| :..:||..|:.    .|..:::|.|..| :||:...:|   :.|:.|.|
plant   293 LQSSIPLLELDLSRNGFTGSISEINSS----TLTMLNLSSNGLSGDLPSSFKSC---SVIDLSGN 350

  Fly   168 RLNNVAVLLRNYRITELVSLDLAYNDLK-QLDQFPEGFSSIRSLQLQSN----ELPSL-PDNFFA 226
            ..:....:::.:..|..| |||:.|:|. .|..|...||.:..|.:::|    .|||| .|:.|:
plant   351 TFSGDVSVVQKWEATPDV-LDLSSNNLSGSLPNFTSAFSRLSVLSIRNNSVSGSLPSLWGDSQFS 414

  Fly   227 VTHARLETLNVSCNKLSTLPRYEQNNHAALVNLSLAGNHLNDSIFEPLHNAAKLRVLHLAYNRIG 291
            |       :::|.||.|..........|:|.:|:|:.|:|...|......|::|.||:
plant   415 V-------IDLSSNKFSGFIPVSFFTFASLRSLNLSRNNLEGPIPFRGSRASELLVLN------- 465

  Fly   292 VLPAACVRNWPELEILVLSGNMLQ-QLPEEVATLGQLRVLRCCNNLLL--CTPQLAKLAMLKVLD 353
                    ::|::|:|.||.|.|. .||.::.|:.:::||...||.|.  ....|.||:.|..||
plant   466 --------SYPQMELLDLSTNSLTGMLPGDIGTMEKIKVLNLANNKLSGELPSDLNKLSGLLFLD 522

  Fly   354 LSHNHLDRVNLLALVPSR----NLKYLDLSGNLQLQVDEQQFKVCQSQSQRHWSLVDVSGNNRAA 414
            ||:|.. :..:...:||:    |:.|.||||            :.....:.:.......||::.:
plant   523 LSNNTF-KGQIPNKLPSQMVGFNVSYNDLSG------------IIPEDLRSYPPSSFYPGNSKLS 574

  Fly   415 LPTTKIRQVSAQRNQNKTSGPWTMGFAETPGSGDCRKLSV-YQLRAANYGGSDEALYGMF----- 473
            ||         .|....:||..::     ||.....|||: ..:..|:.|.:...|:.:|
plant   575 LP---------GRIPADSSGDLSL-----PGKKHHSKLSIRIAIIVASVGAAIMILFVLFAYHRT 625

  Fly   474 --EALEGRGRAAQEMS--------HLVPDLMK-QEQMVKDSAVRDYMKFTLLAAQQQCGSVRSAA 527
              :...||.|...:.:        ...|.|.. ...:.:.|:...:....||.|..:..|.....
plant   626 QLKDFHGRNRFTDQATTRDTKFGRSSRPSLFNFSSNVEQQSSSLSFSNDHLLTANSRSLSGIPGC 690

  Fly   528 LFHLTRTRAPSKVRPLKSKRYVL--------RMASTGG---------------LDAYLIRRTS-- 567
            ...::...||:...|..    :|        |.:|:||               ||.|...|.:
plant   691 EAEISEQGAPATSAPTN----LLDDYPAASGRKSSSGGSPLSSSPRFSDQPVMLDVYSPDRLAGE 751

  Fly   568 ------QLRLT------KPDVIQKDQIH------SMPDPHVLELILSNDDEYLVVGNAQLWSVMD 614
                  .|:||      .|..:.....|      ::.:.|:|.:      ::|.||..:  ...|
plant   752 LFFLDVSLKLTAEELSRAPAEVLGRSSHGTLYKATLDNGHMLTV------KWLRVGLVR--HKKD 808

  Fly   615 IDRAAREI------------------RKEENSLLAAKRLVDIAQSFAAAESLSVIVVRFRHLGTD 661
            ..|.|::|                  |::|..||:         .:...|||::      ||...
plant   809 FAREAKKIGSLKHPNIVPLRAYYWGPREQERLLLS---------DYLRGESLAM------HLYET 858

  Fly   662 VDH------LIRELKQSV-----------RKKP----QPVSLPLSSGSVCKRTCCDRSNACRHRA 705
            ...      ..:.||.:|           |..|    :|.::.|||.....|.    ::.|.||.
plant   859 TPRRYSPMSFSQRLKVAVEVAQCLLYLHDRAMPHGNLKPTNIILSSPDNTVRI----TDYCVHRL 919

  Fly   706 IEQEPLA---------GRSSPSGQSDRDLLAKDKDDEFVLAHARVLQE 744
            :....:|         |.|:|...|....:...|.|  |.|...:|.|
plant   920 MTPSGVAEQILNMSALGYSAPELSSASKPIPTLKSD--VYAFGVILME 965

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Phlpp	NP_001260558.1	leucine-rich repeat	91..110	CDD:275380	8/23 (35%)
		LRR_8	109..169	CDD:290566	16/61 (26%)
		leucine-rich repeat	111..135	CDD:275380	6/24 (25%)
		leucine-rich repeat	136..158	CDD:275380	7/22 (32%)
		leucine-rich repeat	159..183	CDD:275380	3/23 (13%)
		leucine-rich repeat	184..209	CDD:275380	10/25 (40%)
		LRR_8	205..266	CDD:290566	19/65 (29%)
		leucine-rich repeat	210..230	CDD:275380	9/24 (38%)
		leucine-rich repeat	232..255	CDD:275380	4/22 (18%)
		LRR_RI	<256..410	CDD:238064	42/160 (26%)
		leucine-rich repeat	256..276	CDD:275380	6/19 (32%)
		LRR_8	279..359	CDD:290566	27/82 (33%)
		leucine-rich repeat	280..303	CDD:275380	3/22 (14%)
		leucine-rich repeat	304..348	CDD:275380	17/46 (37%)
		leucine-rich repeat	349..372	CDD:275380	8/26 (31%)
		PP2Cc	461..655	CDD:294085	46/270 (17%)
AT5G10020	NP_196564.1	PLN00113	26..1047	CDD:215061	186/828 (22%)
		leucine-rich repeat	80..100	CDD:275380
		leucine-rich repeat	101..124	CDD:275380
		leucine-rich repeat	125..148	CDD:275380
		leucine-rich repeat	149..172	CDD:275380
		leucine-rich repeat	173..196	CDD:275380
		leucine-rich repeat	225..250	CDD:275380	6/21 (29%)
		leucine-rich repeat	251..273	CDD:275380	4/21 (19%)
		leucine-rich repeat	274..320	CDD:275380	14/49 (29%)
		leucine-rich repeat	321..342	CDD:275380	6/20 (30%)
		leucine-rich repeat	368..392	CDD:275380	10/24 (42%)
		leucine-rich repeat	393..436	CDD:275380	13/49 (27%)
		leucine-rich repeat	437..469	CDD:275380	10/46 (22%)
		leucine-rich repeat	470..493	CDD:275380	9/22 (41%)
		leucine-rich repeat	494..515	CDD:275380	6/20 (30%)
		leucine-rich repeat	518..539	CDD:275380	7/21 (33%)
		leucine-rich repeat	540..560	CDD:275380	6/31 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910