DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Phlpp and PIRL1

DIOPT Version :9

Sequence 1:	NP_001260558.1	Gene:	Phlpp / 35178	FlyBaseID:	FBgn0032749	Length:	954	Species:	Drosophila melanogaster
Sequence 2:	NP_196204.1	Gene:	PIRL1 / 830470	AraportID:	AT5G05850	Length:	506	Species:	Arabidopsis thaliana

Alignment Length:	530	Identity:	112/530 - (21%)
Similarity:	187/530 - (35%)	Gaps:	145/530 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 PYKSKLKVSASHS------GPHPLPVEVTAAEEEQAATFGQT--------------SPQKLSLKG 55
            |.||....|::||      .||....:|.|:.....|...||              :..:...:.
plant    37 PSKSDPSSSSNHSIEIVTQMPHLAHPDVLASMTNATADVSQTRSVLRTLGPRPDHETVDRARARL 101

  Fly    56 SQLGGSILIGNYNYL----TQLEVCENEME--------------VLDLSSLAQL--ETLKCSRNK 100
            .::..| |..::..:    ..::|.|.|.:              :|.|:.|.:.  :.||.:..:
plant   102 REIDAS-LSESFEEIALSPNDIDVAEKEQKRREAVEQEKIWYKSILKLNELHESYEKLLKEAEER 165

  Fly   101 LMELIINGTNLQTLVADHNYLHNISTTNTHPVPL-------KLQRIDISHNNFSELPNWVGACAS 158
            |:.:..:.......||:.....  ...|...|.:       .|.|:|:|......||...|....
plant   166 LVRIYESAEKNAAAVAEEEAAE--VEVNEEVVSILQQAAENPLDRVDLSGRKLKLLPEAFGKIQG 228

  Fly   159 LTAINASHNRLNNVAVLLRNYRITELVSLDLAYNDLKQLDQFPE---GFSSIRSLQLQSNELPSL 220
            |..:|..:|                            ||...|:   |..::..|.:.:|.|.:|
plant   229 LLVLNLYNN----------------------------QLQAIPDSIAGLHNLLELDVSTNFLETL 265

  Fly   221 PDNFFAVTHARLETLNVSCNKLSTLPRYEQNNHAALVNLSLAGNHLNDSIFEPLHNAAKLRVLHL 285
            ||:...:  ::|:.||||||||:|||                     |||.    :...|.||..
plant   266 PDSIGLL--SKLKILNVSCNKLTTLP---------------------DSIC----HCGSLVVLDA 303

  Fly   286 AYNRIGVLPAACVRNWPELEILVLSGNMLQQLPEEVATLGQLRVLRCCNNLLLCTP-QLAKLAML 349
            :||.:..||........:||.|::..|.::.||..:..:..||.|....|.|...| ....|..|
plant   304 SYNNLTYLPTNIGFELVKLEKLLIHLNKIRSLPTSIGEMRSLRYLDAHFNELNGLPNSFGLLTNL 368

  Fly   350 KVLDLSHNHLDRVNLLA----LVPSRNLKYLDLSGN---------------LQLQVDEQQFKVCQ 395
            :.|:||.|..|..:|.|    |:   :|:.||||.|               .:|.:|:....|..
plant   369 EYLNLSSNFSDLQDLPASFGDLI---SLQELDLSNNQIHSLPDAFGTLVNLTKLNLDQNPLVVPP 430

  Fly   396 SQSQRHWSLVDV----SGNNRAALPTTKIRQVSAQRNQNKTSGPWTMGFAETPGSGDCRKLSVYQ 456
            .:..:..  ||.    .|....::...:.:..:.:...::|:..|.        :....||..|.
plant   431 DEVVKQG--VDAVKMYMGKRWVSMLEEEEKMANMKDEMDQTNTDWL--------TRTTSKLKTYV 485

  Fly   457 LRAANYGGSD 466
            ...:.|.||:
plant   486 TEVSEYLGSN 495

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Phlpp	NP_001260558.1	leucine-rich repeat	91..110	CDD:275380	3/20 (15%)
		LRR_8	109..169	CDD:290566	14/66 (21%)
		leucine-rich repeat	111..135	CDD:275380	4/30 (13%)
		leucine-rich repeat	136..158	CDD:275380	7/21 (33%)
		leucine-rich repeat	159..183	CDD:275380	3/23 (13%)
		leucine-rich repeat	184..209	CDD:275380	4/27 (15%)
		LRR_8	205..266	CDD:290566	18/60 (30%)
		leucine-rich repeat	210..230	CDD:275380	6/19 (32%)
		leucine-rich repeat	232..255	CDD:275380	12/22 (55%)
		LRR_RI	<256..410	CDD:238064	43/177 (24%)
		leucine-rich repeat	256..276	CDD:275380	3/19 (16%)
		LRR_8	279..359	CDD:290566	25/80 (31%)
		leucine-rich repeat	280..303	CDD:275380	7/22 (32%)
		leucine-rich repeat	304..348	CDD:275380	13/44 (30%)
		leucine-rich repeat	349..372	CDD:275380	9/26 (35%)
		PP2Cc	461..655	CDD:294085	3/6 (50%)
PIRL1	NP_196204.1	LRR_8	206..260	CDD:290566	15/81 (19%)
		leucine-rich repeat	208..228	CDD:275380	6/19 (32%)
		LRR_RI	<212..403	CDD:238064	67/248 (27%)
		leucine-rich repeat	229..251	CDD:275380	7/49 (14%)
		LRR_8	251..308	CDD:290566	26/83 (31%)
		leucine-rich repeat	252..274	CDD:275380	6/23 (26%)
		leucine-rich repeat	275..297	CDD:275380	15/46 (33%)
		leucine-rich repeat	298..321	CDD:275380	7/22 (32%)
		LRR_8	321..376	CDD:290566	17/54 (31%)
		leucine-rich repeat	322..344	CDD:275380	6/21 (29%)
		leucine-rich repeat	345..367	CDD:275380	7/21 (33%)
		LRR_8	366..426	CDD:290566	17/62 (27%)
		LRR_4	366..408	CDD:289563	15/44 (34%)
		leucine-rich repeat	368..392	CDD:275380	9/26 (35%)
		LRR_4	392..>426	CDD:289563	8/33 (24%)
		leucine-rich repeat	393..415	CDD:275380	6/21 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR45752
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100