DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Phlpp and BRI1

DIOPT Version :9

Sequence 1:	NP_001260558.1	Gene:	Phlpp / 35178	FlyBaseID:	FBgn0032749	Length:	954	Species:	Drosophila melanogaster
Sequence 2:	NP_195650.1	Gene:	BRI1 / 830095	AraportID:	AT4G39400	Length:	1196	Species:	Arabidopsis thaliana

Alignment Length:	991	Identity:	215/991 - (21%)
Similarity:	332/991 - (33%)	Gaps:	352/991 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 KVSASHSGPHPLPVEVTAAEEEQAATFGQTSPQKLSLKGSQLGGSI------------------L 63
            ||::......||.|..:|.   .::....|..:.|.|..|.:.||:                  |
plant    73 KVTSIDLSSKPLNVGFSAV---SSSLLSLTGLESLFLSNSHINGSVSGFKCSASLTSLDLSRNSL 134

  Fly    64 IGNYNYLTQLEVCE------------------------NEMEVLDLSS----------------L 88
            .|....||.|..|.                        |.:||||||:                .
plant   135 SGPVTTLTSLGSCSGLKFLNVSSNTLDFPGKVSGGLKLNSLEVLDLSANSISGANVVGWVLSDGC 199

  Fly    89 AQLETLKCSRNKLMELIING-------TNLQTL-VADHNY------------------------- 120
            .:|:.|..|.||     |:|       .||:.| |:.:|:
plant   200 GELKHLAISGNK-----ISGDVDVSRCVNLEFLDVSSNNFSTGIPFLGDCSALQHLDISGNKLSG 259

  Fly   121 -------------LHNISTTN----THPVPLK-LQRIDISHNNFS-ELPNWV-GACASLTAINAS 165
                         |.|||:..    ..|:||| ||.:.::.|.|: |:|::: |||.:||.::.|
plant   260 DFSRAISTCTELKLLNISSNQFVGPIPPLPLKSLQYLSLAENKFTGEIPDFLSGACDTLTGLDLS 324

  Fly   166 HNR--------------LNNVAVLLRNY----------RITELVSLDLAYNDLKQLDQFPEGFSS 206
            .|.              |.::|:...|:          ::..|..|||::|:.
plant   325 GNHFYGAVPPFFGSCSLLESLALSSNNFSGELPMDTLLKMRGLKVLDLSFNEF------------ 377

  Fly   207 IRSLQLQSNELPSLPDNFFAVTHARLETLNVSCNKLS--TLPRYEQNNHAALVNLSLAGNHLNDS 269
                   |.|||....|.    .|.|.||::|.|..|  .||...||....|..|.|..|.....
plant   378 -------SGELPESLTNL----SASLLTLDLSSNNFSGPILPNLCQNPKNTLQELYLQNNGFTGK 431

  Fly   270 IFEPLHNAAKLRVLHLAYNRI-GVLPAACVRNWPELEILVLSGNMLQ-QLPEEVATLGQLRVLRC 332
            |...|.|.::|..|||::|.: |.:|:: :.:..:|..|.|..|||: ::|:|:..:..|..|..
plant   432 IPPTLSNCSELVSLHLSFNYLSGTIPSS-LGSLSKLRDLKLWLNMLEGEIPQELMYVKTLETLIL 495

  Fly   333 -CNNLLLCTPQ-LAKLAMLKVLDLSHNHLDRVNLLALVPS-----RNLKYLDLSGNLQLQVDEQQ 390
             .|:|....|. |:....|..:.||:|     .|...:|.     .||..|.||.|
plant   496 DFNDLTGEIPSGLSNCTNLNWISLSNN-----RLTGEIPKWIGRLENLAILKLSNN--------- 546

  Fly   391 FKVCQSQSQRHWSLVDVSGNNRAALPTTKIRQVSAQRNQNKTSGPWTMGFAETPGSGDCRKLSVY 455
                           ..|||..|.|                               ||||.|...
plant   547 ---------------SFSGNIPAEL-------------------------------GDCRSLIWL 565

  Fly   456 QLRAANYGGS-DEALYGMFEALEGRGRAAQEMSHLVPDLMKQEQMVKDSAVRDYMKFTLLAAQQQ 519
            .|....:.|: ..|::.....:.....|.:...::..|.||:|         .:....||..|
plant   566 DLNTNLFNGTIPAAMFKQSGKIAANFIAGKRYVYIKNDGMKKE---------CHGAGNLLEFQ-- 619

  Fly   520 CGSVRSAALFHLTRTRAPSKVRPLKSKRYVLRMAST---GGLDAYLIRRTSQLRLTKPDVIQKDQ 581
              .:||..|..|: ||.|..:   .|:.|....:.|   .|...:|....:.|....|     .:
plant   620 --GIRSEQLNRLS-TRNPCNI---TSRVYGGHTSPTFDNNGSMMFLDMSYNMLSGYIP-----KE 673

  Fly   582 IHSMPDPHVLELILSND------DEYLVVGNAQLWSVMDIDRAAREIRKEENSLLAAKRLVDIAQ 640
            |.|||...:|.| ..||      ||   ||:.:..:::|:.....:.|              |.|
plant   674 IGSMPYLFILNL-GHNDISGSIPDE---VGDLRGLNILDLSSNKLDGR--------------IPQ 720

  Fly   641 SFAAAESLSVIVVRFRHLGTDVDHLIRELKQSVRKKPQPVSLP----LSSGSVCKRTC--CDRSN 699
            :.:|...|           |::|.....|...:.:..|..:.|    |::..:|....  ||.||
plant   721 AMSALTML-----------TEIDLSNNNLSGPIPEMGQFETFPPAKFLNNPGLCGYPLPRCDPSN 774

  Fly   700 A---CRH-RAIEQEPLAGRSSPSGQSDRDLLAKDKDDEFVLAHARVL----------QEEQQLEM 750
            |   ..| |:..:.|    :|.:|.....||.     .||.....:|          ::|.:|||
plant   775 ADGYAHHQRSHGRRP----ASLAGSVAMGLLF-----SFVCIFGLILVGREMRKRRRKKEAELEM 830

  Fly   751 LDETESVSESVLSEEQFKCWEYMLEQNTQLLFDKELNTISKSFTKQRTVPNAIMAATVLPERNDF 815
            ..|....|.                       |:..|..:...|..:...:..:||...|.|...
plant   831 YAEGHGNSG-----------------------DRTANNTNWKLTGVKEALSINLAAFEKPLRKLT 872

  Fly   816 TSNLMRTVTNKFISTS 831
            .::|:: .||.|.:.|
plant   873 FADLLQ-ATNGFHNDS 887

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Phlpp	NP_001260558.1	leucine-rich repeat	91..110	CDD:275380	7/25 (28%)
		LRR_8	109..169	CDD:290566	26/119 (22%)
		leucine-rich repeat	111..135	CDD:275380	10/66 (15%)
		leucine-rich repeat	136..158	CDD:275380	9/23 (39%)
		leucine-rich repeat	159..183	CDD:275380	7/47 (15%)
		leucine-rich repeat	184..209	CDD:275380	5/24 (21%)
		LRR_8	205..266	CDD:290566	20/62 (32%)
		leucine-rich repeat	210..230	CDD:275380	5/19 (26%)
		leucine-rich repeat	232..255	CDD:275380	10/24 (42%)
		LRR_RI	<256..410	CDD:238064	41/162 (25%)
		leucine-rich repeat	256..276	CDD:275380	6/19 (32%)
		LRR_8	279..359	CDD:290566	25/83 (30%)
		leucine-rich repeat	280..303	CDD:275380	7/23 (30%)
		leucine-rich repeat	304..348	CDD:275380	14/46 (30%)
		leucine-rich repeat	349..372	CDD:275380	6/27 (22%)
		PP2Cc	461..655	CDD:294085	42/203 (21%)
BRI1	NP_195650.1	PLN00113	35..1146	CDD:215061	215/991 (22%)
		LRR_RI	<116..402	CDD:238064	65/313 (21%)
		leucine-rich repeat	124..146	CDD:275380	5/21 (24%)
		leucine-rich repeat	150..174	CDD:275380	0/23 (0%)
		leucine-rich repeat	175..201	CDD:275380	6/25 (24%)
		leucine-rich repeat	202..223	CDD:275380	7/25 (28%)
		leucine-rich repeat	224..246	CDD:275380	4/21 (19%)
		leucine-rich repeat	247..270	CDD:275380	0/22 (0%)
		leucine-rich repeat	271..292	CDD:275380	7/20 (35%)
		leucine-rich repeat	293..317	CDD:275380	9/23 (39%)
		LRR_RI	363..>556	CDD:238064	65/245 (27%)
		leucine-rich repeat	367..391	CDD:275380	10/46 (22%)
		leucine-rich repeat	392..416	CDD:275380	10/23 (43%)
		leucine-rich repeat	418..441	CDD:275380	7/22 (32%)
		leucine-rich repeat	442..465	CDD:275380	7/23 (30%)
		leucine-rich repeat	466..489	CDD:275380	8/22 (36%)
		leucine-rich repeat	490..513	CDD:275380	6/22 (27%)
		leucine-rich repeat	514..537	CDD:275380	6/27 (22%)
		leucine-rich repeat	538..561	CDD:275380	13/77 (17%)
		leucine-rich repeat	656..679	CDD:275380	6/27 (22%)
		leucine-rich repeat	680..703	CDD:275380	8/26 (31%)
		leucine-rich repeat	704..727	CDD:275380	5/36 (14%)
		STKc_IRAK	889..1158	CDD:270968
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910